RGD Reference Report - Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma. - Rat Genome Database

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Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma.

Authors: Holmgren, L  Flam, F  Larsson, E  Ohlsson, R 
Citation: Holmgren L, etal., Cancer Res. 1993 Jun 15;53(12):2927-31.
RGD ID: 2292200
Pubmed: PMID:8504434   (View Abstract at PubMed)

The hydatidiform mole is a benign disease of the placenta characterized by the absence of the maternal genome. Approximately 3% of the reported cases will develop into malignant choriocarcinoma. In situ hybridization analysis reveals that the paternal platelet-derived growth factor (PDGF) beta receptor gene is up to 2 orders of magnitude more active in cytotrophoblasts of the complete hydatidiform moles than in normal placentae. The transition between hyperplasia (complete hydatidiform mole) and neoplasia (choriocarcinoma) in these cells correlates with at least a 10- to 20-fold activation of the PDGF-B gene. Since the neoplastic cytotrophoblasts have maintained an abnormally high level of PDGF beta receptor expression, we propose that a deregulated PDGF autostimulatory loop is involved in the genesis of human choriocarcinoma from hydatidiform moles.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
choriocarcinoma  IEP 2292200; 2292200mRNA:increased expression:mononuclear cytotrophoblast cellRGD 
choriocarcinoma  ISOPDGFB (Homo sapiens)2292200; 2292200mRNA:increased expression:mononuclear cytotrophoblast cellRGD 
choriocarcinoma  ISOPDGFRB (Homo sapiens)2292200; 2292200mRNA:increased expression:mononuclear cytotrophoblast cellRGD 
Hydatidiform Mole  IEP 2292200mRNA:increased expression:mononuclear cytotrophoblast cellRGD 
Hydatidiform Mole  ISOPDGFRB (Homo sapiens)2292200; 2292200mRNA:increased expression:mononuclear cytotrophoblast cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdgfb  (platelet derived growth factor subunit B)
Pdgfrb  (platelet derived growth factor receptor beta)

Genes (Mus musculus)
Pdgfb  (platelet derived growth factor, B polypeptide)
Pdgfrb  (platelet derived growth factor receptor, beta polypeptide)

Genes (Homo sapiens)
PDGFB  (platelet derived growth factor subunit B)
PDGFRB  (platelet derived growth factor receptor beta)


Additional Information