Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) - Rat Genome Database

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Gene: Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) Rattus norvegicus
Analyze
Symbol: Kcnma1
Name: potassium calcium-activated channel subfamily M alpha 1
RGD ID: 620715
Description: Enables identical protein binding activity and monoatomic ion channel activity. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1); INTERACTS WITH (+)-pilocarpine; (+)-Pimaric acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BK channel; BKCa; BKCA alpha; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; cbv1; k(VCA)alpha; KCa1.1; Kcnma; KCNMA1b; KCNMA1c; LOC498438; maxi K channel; maxiK; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo; slo homolog; slo-alpha; slo1; slowpoke homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnma1_v1   Kcnma1_v2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815351,065 - 1,057,117 (+)NCBIGRCr8
mRatBN7.215302,480 - 1,007,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15302,214 - 1,001,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15309,515 - 1,014,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0151,696,105 - 2,401,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015308,241 - 1,013,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (EXP)
(R)-noradrenaline  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caesium atom  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
genistein  (ISO)
glucose  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
Lasiocarpine  (ISO)
lithocholic acid  (EXP,ISO)
malathion  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mifepristone  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
NS 1619  (ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
paxilline  (EXP)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pergolide  (EXP)
phloretin  (EXP)
piroxicam  (ISO)
potassium atom  (EXP,ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyridaben  (ISO)
rubidium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium disulfite  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraethylammonium  (ISO)
thallium  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Stimulatory action of internal protons on Slo1 BK channels. Avdonin V, etal., Biophys J. 2003 May;84(5):2969-80.
2. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, etal., Science. 2006 Oct 27;314(5799):615-20.
3. Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease. Burns LC, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):507-12. doi: 10.1002/ajmg.b.31194. Epub 2011 Apr 7.
4. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Chen M, etal., Mol Neurobiol. 2013 Dec;48(3):794-807. doi: 10.1007/s12035-013-8467-x. Epub 2013 May 8.
5. Steady-state and closed-state inactivation properties of inactivating BK channels. Ding JP and Lingle CJ, Biophys J 2002 May;82(5):2448-65.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Properties of large conductance calcium-activated potassium channels in pyramidal neurons from the hippocampal CA1 region of adult rats. Gong LW, etal., Jpn J Physiol 2001 Dec;51(6):725-31.
8. Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Ha TS, etal., Biophys J. 2004 May;86(5):2871-82.
9. Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues. Ha TS, etal., Eur J Biochem 2000 Feb;267(3):910-8.
10. Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. Hu H, etal., J Neurosci. 2001 Dec 15;21(24):9585-97.
11. Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Iozzi D, etal., Acta Physiol (Oxf). 2013 Aug;208(4):329-39. doi: 10.1111/apha.12083. Epub 2013 Mar 25.
12. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Jaggar JH, etal., Circ Res. 2005 Oct 14;97(8):805-12. doi: 10.1161/01.RES.0000186180.47148.7b. Epub 2005 Sep 15.
13. Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. Jing F, etal., J Pharm Pharmacol. 2013 Jun;65(6):847-54. doi: 10.1111/jphp.12041. Epub 2013 Feb 28.
14. Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. Jo S, etal., J Neurochem. 2005 Sep;94(5):1212-24. Epub 2005 Jul 25.
15. Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1). Kanthesh BM, etal., Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C972-80. doi: 10.1152/ajpcell.00165.2013. Epub 2013 Aug 28.
16. Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channel. Kim H, etal., Proteomics. 2007 Aug;7(15):2591-602.
17. Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development. Lai GJ and McCobb DP, Endocrinology. 2006 Aug;147(8):3961-7. Epub 2006 May 4.
18. Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells. Lai GJ and McCobb DP, Proc Natl Acad Sci U S A 2002 May 28;99(11):7722-7.
19. Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation. Li M, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101. doi: 10.1073/pnas.1002685107. Epub 2010 Oct 19.
20. Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. Liu G, etal., EMBO J. 2004 Jun 2;23(11):2196-205. Epub 2004 May 13.
21. Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Liu Y, etal., Hypertension. 1997 Dec;30(6):1403-9. doi: 10.1161/01.hyp.30.6.1403.
22. Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging. Marijic J, etal., Circ Res. 2001 Feb 2;88(2):210-6.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Identification and localization of Ca(2+)-activated K+ channels in rat sciatic nerve. Mi H, etal., Glia. 1999 Apr;26(2):166-75.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. Park SM, etal., FEBS Lett. 2004 Jul 16;570(1-3):143-8.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Shanley LJ, etal., Nat Neurosci 2002 Apr;5(4):299-300.
32. Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of alpha- and beta1-subunit expression. Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
33. Nitric oxide enhances Ca(2+)-dependent K(+) channel activity in rat carotid body cells. Silva JM and Lewis DL, Pflugers Arch 2002 Mar;443(5-6):671-5.
34. MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Singh H, etal., Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10836-41. doi: 10.1073/pnas.1302028110. Epub 2013 Jun 10.
35. [Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats]. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
36. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Williams SE, etal., Science. 2004 Dec 17;306(5704):2093-7. Epub 2004 Nov 4.
37. Control of alternative splicing of potassium channels by stress hormones. Xie J and McCobb DP, Science 1998 Apr 17;280(5362):443-6.
38. Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. Zhu N, etal., FEBS Lett. 2005 Aug 29;579(21):4856-60.
Additional References at PubMed
PMID:7573516   PMID:7687074   PMID:7877450   PMID:7993625   PMID:10517674   PMID:10840032   PMID:11245614   PMID:11278440   PMID:11641143   PMID:11880513   PMID:12388065   PMID:12388098  
PMID:12454985   PMID:12547730   PMID:12949219   PMID:12952984   PMID:14523450   PMID:15049854   PMID:15184377   PMID:15194823   PMID:15328414   PMID:15703204   PMID:15827347   PMID:15867178  
PMID:16081418   PMID:16306267   PMID:16341213   PMID:16566008   PMID:16763026   PMID:16845385   PMID:16873365   PMID:16997278   PMID:17074442   PMID:17097837   PMID:17122062   PMID:17135251  
PMID:17150299   PMID:17166942   PMID:17259072   PMID:17303127   PMID:17468198   PMID:17701422   PMID:17706472   PMID:18079116   PMID:18180950   PMID:18250327   PMID:18458941   PMID:18562499  
PMID:18573811   PMID:18953570   PMID:19168436   PMID:19651031   PMID:19940072   PMID:20574420   PMID:20713546   PMID:20817829   PMID:20933547   PMID:20936291   PMID:20938677   PMID:21079807  
PMID:21158046   PMID:21186374   PMID:21325638   PMID:21900688   PMID:22052159   PMID:22131374   PMID:22322970   PMID:22350354   PMID:22555843   PMID:22570490   PMID:22633934   PMID:22808126  
PMID:22871113   PMID:22882938   PMID:23376485   PMID:23646921   PMID:23872879   PMID:23937098   PMID:24397812   PMID:24462688   PMID:24602615   PMID:24729485   PMID:24836752   PMID:25139746  
PMID:25192641   PMID:25371198   PMID:25481230   PMID:25494655   PMID:25661478   PMID:25864652   PMID:26277265   PMID:26755740   PMID:26791489   PMID:26823461   PMID:27329042   PMID:28075010  
PMID:28665272   PMID:28672269   PMID:29508439   PMID:29558628   PMID:30612588   PMID:30991005   PMID:31152168   PMID:32967457   PMID:33452855   PMID:34267344   PMID:34271438   PMID:35043645  
PMID:35489424   PMID:37598353  


Genomics

Comparative Map Data
Kcnma1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815351,065 - 1,057,117 (+)NCBIGRCr8
mRatBN7.215302,480 - 1,007,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15302,214 - 1,001,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15309,515 - 1,014,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0151,696,105 - 2,401,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015308,241 - 1,013,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381076,869,602 - 77,637,808 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1076,869,601 - 77,638,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371078,629,360 - 79,397,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361078,299,366 - 79,067,583 (-)NCBINCBI36Build 36hg18NCBI36
Build 341078,314,640 - 79,067,583NCBI
Celera1071,914,113 - 72,684,182 (-)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1072,624,294 - 73,391,824 (-)NCBIHuRef
CHM1_11078,911,952 - 79,680,009 (-)NCBICHM1_1
T2T-CHM13v2.01077,738,326 - 78,506,527 (-)NCBIT2T-CHM13v2.0
Kcnma1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391423,342,356 - 24,055,173 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1423,339,499 - 24,064,559 (-)EnsemblGRCm39 Ensembl
GRCm381423,292,288 - 24,005,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1423,289,431 - 24,014,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv371424,117,983 - 24,823,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361422,088,573 - 22,792,482 (-)NCBIMGSCv36mm8
Celera1419,676,577 - 20,379,488 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1412.92NCBI
Kcnma1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543714,749,914 - 15,454,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543714,749,808 - 15,457,274 (+)NCBIChiLan1.0ChiLan1.0
KCNMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2889,019,281 - 89,786,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11089,024,606 - 89,791,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01073,391,297 - 74,158,488 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11076,053,915 - 76,820,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1076,062,047 - 76,820,644 (-)Ensemblpanpan1.1panPan2
KCNMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1426,844,250 - 27,338,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl426,844,250 - 27,555,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha426,970,672 - 27,681,029 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0427,145,564 - 27,857,706 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl427,143,848 - 27,857,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1427,020,780 - 27,731,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0427,220,327 - 27,931,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0427,571,588 - 28,283,070 (-)NCBIUU_Cfam_GSD_1.0
Kcnma1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721353,507,382 - 54,220,539 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365212,000,109 - 2,705,365 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365212,000,113 - 2,706,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1479,352,005 - 80,106,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11479,345,382 - 80,106,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21485,796,582 - 85,996,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,640,231 - 86,640,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,138,921 - 86,358,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1953,727,790 - 54,557,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl954,182,910 - 54,554,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604814,223,140 - 14,987,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnma1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475410,153,809 - 10,885,079 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475410,152,635 - 10,885,239 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnma1
3602 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000065542, ENSRNOT00000066928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat

Markers in Region
D15Rat73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215821,049 - 821,287 (+)MAPPERmRatBN7.2
Rnor_6.015873,565 - 873,802NCBIRnor6.0
Rnor_5.015862,384 - 862,621UniSTSRnor5.0
RGSC_v3.415766,501 - 766,738UniSTSRGSC3.4
RGSC_v3.415766,261 - 766,899RGDRGSC3.4
RGSC_v3.115766,502 - 766,738RGD
Celera153,729,257 - 3,729,494UniSTS
RH 3.4 Map1534.9RGD
RH 3.4 Map1534.9UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map153.9298RGD
FHH x ACI Map150.04RGD
Cytogenetic Map15p16UniSTS
D15Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215616,969 - 617,127 (+)MAPPERmRatBN7.2
Rnor_6.015668,009 - 668,166NCBIRnor6.0
Rnor_5.015658,019 - 658,176UniSTSRnor5.0
RGSC_v3.415557,527 - 557,682RGDRGSC3.4
RGSC_v3.415557,528 - 557,685UniSTSRGSC3.4
RGSC_v3.115557,527 - 557,682RGD
Celera153,933,166 - 3,933,327UniSTS
FHH x ACI Map150.0RGD
FHH x ACI Map150.0UniSTS
Cytogenetic Map15p16UniSTS
D15Rat135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215568,533 - 568,738 (+)MAPPERmRatBN7.2
Rnor_6.015613,195 - 613,399NCBIRnor6.0
Rnor_5.015603,180 - 603,384UniSTSRnor5.0
RGSC_v3.415506,685 - 506,890RGDRGSC3.4
RGSC_v3.415506,686 - 506,890UniSTSRGSC3.4
RGSC_v3.115506,487 - 507,058RGD
Celera153,981,511 - 3,981,715UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map155.0199RGD
Cytogenetic Map15p16UniSTS
U09383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2151,000,025 - 1,000,132 (+)MAPPERmRatBN7.2
Rnor_6.0151,047,677 - 1,047,783NCBIRnor6.0
Rnor_5.0151,035,933 - 1,036,039UniSTSRnor5.0
RGSC_v3.415949,103 - 949,209UniSTSRGSC3.4
Celera153,557,333 - 3,557,439UniSTS
Cytogenetic Map15p16UniSTS
D14Mit208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215874,983 - 875,093 (+)MAPPERmRatBN7.2
Rnor_6.015927,494 - 927,603NCBIRnor6.0
Rnor_5.015916,313 - 916,422UniSTSRnor5.0
RGSC_v3.415820,431 - 820,540UniSTSRGSC3.4
Celera153,675,470 - 3,675,579UniSTS
Cytogenetic Map15p16UniSTS
BE113518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215355,078 - 355,236 (+)MAPPERmRatBN7.2
Rnor_6.015399,231 - 399,388NCBIRnor6.0
Rnor_5.015391,958 - 392,115UniSTSRnor5.0
RGSC_v3.415375,345 - 375,502UniSTSRGSC3.4
Celera154,193,257 - 4,193,414UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
WI-18797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215990,952 - 991,117 (+)MAPPERmRatBN7.2
Rnor_6.0151,038,604 - 1,038,768NCBIRnor6.0
Rnor_5.0151,026,860 - 1,027,024UniSTSRnor5.0
RGSC_v3.415940,030 - 940,194UniSTSRGSC3.4
Celera153,566,352 - 3,566,516UniSTS
Cytogenetic Map15p16UniSTS
BF386160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215711,476 - 711,641 (+)MAPPERmRatBN7.2
Rnor_6.015763,072 - 763,236NCBIRnor6.0
Rnor_5.015751,868 - 752,032UniSTSRnor5.0
RGSC_v3.415656,277 - 656,441UniSTSRGSC3.4
Celera153,838,910 - 3,839,074UniSTS
RH 3.4 Map1535.0UniSTS
Cytogenetic Map15p16UniSTS
BE101789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215530,055 - 530,205 (+)MAPPERmRatBN7.2
Rnor_6.015575,219 - 575,368NCBIRnor6.0
Rnor_5.015564,821 - 564,970UniSTSRnor5.0
Celera154,020,245 - 4,020,394UniSTS
RH 3.4 Map1531.6UniSTS
Cytogenetic Map15p16UniSTS
BF405369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215313,741 - 313,922 (+)MAPPERmRatBN7.2
Rnor_6.015355,864 - 356,044NCBIRnor6.0
Rnor_5.015350,760 - 350,940UniSTSRnor5.0
RGSC_v3.415333,999 - 334,179UniSTSRGSC3.4
Celera154,234,546 - 4,234,726UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
Kcnma1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215871,373 - 871,451 (+)MAPPERmRatBN7.2
Rnor_6.015923,884 - 923,961NCBIRnor6.0
Rnor_5.015912,703 - 912,780UniSTSRnor5.0
RGSC_v3.415816,821 - 816,898UniSTSRGSC3.4
Celera153,679,111 - 3,679,188UniSTS
Cytogenetic Map15p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 1 1 52 4 1
Low 3 13 10 17 7 10 22 34 37 9 7
Below cutoff 28 16 16 2 16 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB248959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB248960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF135265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ517197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY330294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY344964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY344965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U40603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U55995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065542   ⟹   ENSRNOP00000058962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
Rnor_6.0 Ensembl15344,685 - 1,047,625 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066928   ⟹   ENSRNOP00000061684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,585 - 1,000,263 (+)Ensembl
Rnor_6.0 Ensembl15344,710 - 1,047,914 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077671   ⟹   ENSRNOP00000074702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,214 - 1,000,252 (+)Ensembl
Rnor_6.0 Ensembl15344,360 - 1,047,903 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091318   ⟹   ENSRNOP00000071652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15497,821 - 1,000,263 (+)Ensembl
Rnor_6.0 Ensembl15675,085 - 1,047,956 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096488   ⟹   ENSRNOP00000090930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105174   ⟹   ENSRNOP00000086150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109388   ⟹   ENSRNOP00000096569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15497,821 - 991,893 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109865   ⟹   ENSRNOP00000082424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,214 - 991,893 (+)Ensembl
RefSeq Acc Id: NM_001393699   ⟹   NP_001380628
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_001393700   ⟹   NP_001380629
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_001393701   ⟹   NP_001380630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_031828   ⟹   NP_114016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
Rnor_6.015344,204 - 1,048,849 (+)NCBI
Rnor_5.015339,100 - 1,037,105 (+)NCBI
RGSC_v3.415575,136 - 950,275 (+)RGD
Celera153,556,267 - 4,246,392 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274699   ⟹   XP_063130769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274700   ⟹   XP_063130770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274701   ⟹   XP_063130771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274702   ⟹   XP_063130772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274703   ⟹   XP_063130773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274704   ⟹   XP_063130774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,245 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274705   ⟹   XP_063130775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,245 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274706   ⟹   XP_063130776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274707   ⟹   XP_063130777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274708   ⟹   XP_063130778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,247 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274709   ⟹   XP_063130779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274710   ⟹   XP_063130780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274711   ⟹   XP_063130781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274712   ⟹   XP_063130782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274713   ⟹   XP_063130783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274714   ⟹   XP_063130784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274715   ⟹   XP_063130785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,247 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274716   ⟹   XP_063130786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274717   ⟹   XP_063130787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,249 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274718   ⟹   XP_063130788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274719   ⟹   XP_063130789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274720   ⟹   XP_063130790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,249 - 1,042,711 (+)NCBI
RefSeq Acc Id: XM_063274721   ⟹   XP_063130791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,251 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274722   ⟹   XP_063130792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274723   ⟹   XP_063130793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274724   ⟹   XP_063130794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274725   ⟹   XP_063130795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274726   ⟹   XP_063130796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,084 - 596,200 (+)NCBI
RefSeq Acc Id: XM_063274727   ⟹   XP_063130797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,179 - 759,238 (+)NCBI
RefSeq Acc Id: XM_063274728   ⟹   XP_063130798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,065 - 382,168 (+)NCBI
RefSeq Acc Id: XM_063274729   ⟹   XP_063130799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274730   ⟹   XP_063130800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,042,711 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380628 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380629 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380630 (Get FASTA)   NCBI Sequence Viewer  
  NP_114016 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130769 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130772 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130773 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130774 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130775 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130776 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130777 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130778 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130779 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130780 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130781 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130782 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130783 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130784 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130785 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130786 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130787 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130788 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130789 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130790 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130791 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130792 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130793 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130794 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130795 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130796 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130797 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130798 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130799 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130800 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA99161 (Get FASTA)   NCBI Sequence Viewer  
  AAB51398 (Get FASTA)   NCBI Sequence Viewer  
  AAB96356 (Get FASTA)   NCBI Sequence Viewer  
  AAC32866 (Get FASTA)   NCBI Sequence Viewer  
  AAC32867 (Get FASTA)   NCBI Sequence Viewer  
  AAC43041 (Get FASTA)   NCBI Sequence Viewer  
  AAD34786 (Get FASTA)   NCBI Sequence Viewer  
  AAP82450 (Get FASTA)   NCBI Sequence Viewer  
  AAP82451 (Get FASTA)   NCBI Sequence Viewer  
  AAP82452 (Get FASTA)   NCBI Sequence Viewer  
  AAP82453 (Get FASTA)   NCBI Sequence Viewer  
  AAP82454 (Get FASTA)   NCBI Sequence Viewer  
  AAR06262 (Get FASTA)   NCBI Sequence Viewer  
  AAR06263 (Get FASTA)   NCBI Sequence Viewer  
  BAI44641 (Get FASTA)   NCBI Sequence Viewer  
  BAI44642 (Get FASTA)   NCBI Sequence Viewer  
  CAD56885 (Get FASTA)   NCBI Sequence Viewer  
  CAD56886 (Get FASTA)   NCBI Sequence Viewer  
  CAD56887 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058962.4
  ENSRNOP00000061684
  ENSRNOP00000061684.3
  ENSRNOP00000071652.2
  ENSRNOP00000074702.2
  ENSRNOP00000082424
  ENSRNOP00000082424.1
  ENSRNOP00000086150
  ENSRNOP00000086150.1
  ENSRNOP00000090930
  ENSRNOP00000090930.1
  ENSRNOP00000096569.1
GenBank Protein Q62976 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_114016   ⟸   NM_031828
- Peptide Label: isoform 1
- UniProtKB: Q9WUI3 (UniProtKB/Swiss-Prot),   Q7TQ57 (UniProtKB/Swiss-Prot),   Q7TQ56 (UniProtKB/Swiss-Prot),   Q7TQ55 (UniProtKB/Swiss-Prot),   Q7TMZ8 (UniProtKB/Swiss-Prot),   Q7TMZ7 (UniProtKB/Swiss-Prot),   Q62976 (UniProtKB/Swiss-Prot),   O88659 (UniProtKB/Swiss-Prot),   O55180 (UniProtKB/Swiss-Prot),   O08626 (UniProtKB/Swiss-Prot),   A0A8I6A598 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058962   ⟸   ENSRNOT00000065542
RefSeq Acc Id: ENSRNOP00000074702   ⟸   ENSRNOT00000077671
RefSeq Acc Id: ENSRNOP00000071652   ⟸   ENSRNOT00000091318
RefSeq Acc Id: ENSRNOP00000061684   ⟸   ENSRNOT00000066928
RefSeq Acc Id: ENSRNOP00000082424   ⟸   ENSRNOT00000109865
RefSeq Acc Id: ENSRNOP00000096569   ⟸   ENSRNOT00000109388
RefSeq Acc Id: ENSRNOP00000090930   ⟸   ENSRNOT00000096488
RefSeq Acc Id: ENSRNOP00000086150   ⟸   ENSRNOT00000105174
RefSeq Acc Id: NP_001380628   ⟸   NM_001393699
- Peptide Label: isoform 2
- UniProtKB: A6KKU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380629   ⟸   NM_001393700
- Peptide Label: isoform 3
- UniProtKB: A6KKU6 (UniProtKB/TrEMBL),   A6KKU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380630   ⟸   NM_001393701
- Peptide Label: isoform 4
- UniProtKB: Q9WUI3 (UniProtKB/Swiss-Prot),   Q7TQ57 (UniProtKB/Swiss-Prot),   Q7TQ56 (UniProtKB/Swiss-Prot),   Q7TQ55 (UniProtKB/Swiss-Prot),   Q7TMZ8 (UniProtKB/Swiss-Prot),   Q7TMZ7 (UniProtKB/Swiss-Prot),   Q62976 (UniProtKB/Swiss-Prot),   O88659 (UniProtKB/Swiss-Prot),   O55180 (UniProtKB/Swiss-Prot),   O08626 (UniProtKB/Swiss-Prot),   A0A8I6ABY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130798   ⟸   XM_063274728
- Peptide Label: isoform X30
RefSeq Acc Id: XP_063130796   ⟸   XM_063274726
- Peptide Label: isoform X28
RefSeq Acc Id: XP_063130797   ⟸   XM_063274727
- Peptide Label: isoform X29
RefSeq Acc Id: XP_063130769   ⟸   XM_063274699
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130770   ⟸   XM_063274700
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130776   ⟸   XM_063274706
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130777   ⟸   XM_063274707
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063130772   ⟸   XM_063274702
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063130773   ⟸   XM_063274703
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063130774   ⟸   XM_063274704
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063130775   ⟸   XM_063274705
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063130779   ⟸   XM_063274709
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063130780   ⟸   XM_063274710
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063130771   ⟸   XM_063274701
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130785   ⟸   XM_063274715
- Peptide Label: isoform X17
- UniProtKB: F1LNC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130778   ⟸   XM_063274708
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063130784   ⟸   XM_063274714
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063130781   ⟸   XM_063274711
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063130799   ⟸   XM_063274729
- Peptide Label: isoform X31
RefSeq Acc Id: XP_063130787   ⟸   XM_063274717
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063130790   ⟸   XM_063274720
- Peptide Label: isoform X22
RefSeq Acc Id: XP_063130786   ⟸   XM_063274716
- Peptide Label: isoform X18
- UniProtKB: A6KKU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130793   ⟸   XM_063274723
- Peptide Label: isoform X25
RefSeq Acc Id: XP_063130782   ⟸   XM_063274712
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063130783   ⟸   XM_063274713
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063130792   ⟸   XM_063274722
- Peptide Label: isoform X24
RefSeq Acc Id: XP_063130794   ⟸   XM_063274724
- Peptide Label: isoform X26
RefSeq Acc Id: XP_063130800   ⟸   XM_063274730
- Peptide Label: isoform X32
RefSeq Acc Id: XP_063130791   ⟸   XM_063274721
- Peptide Label: isoform X23
- UniProtKB: A6KKU5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130795   ⟸   XM_063274725
- Peptide Label: isoform X27
RefSeq Acc Id: XP_063130788   ⟸   XM_063274718
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063130789   ⟸   XM_063274719
- Peptide Label: isoform X21
Protein Domains
Ca2+-activated K+ channel Slowpoke-like C-terminal   Calcium-activated potassium channel BK alpha   Ion transport   RCK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62976-F1-model_v2 AlphaFold Q62976 1-1209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699549
Promoter ID:EPDNEW_R10067
Type:multiple initiation site
Name:Kcnma1_1
Description:potassium calcium-activated channel subfamily M alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015344,718 - 344,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620715 AgrOrtholog
BioCyc Gene G2FUF-14611 BioCyc
Ensembl Genes ENSRNOG00000005985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065542.5 UniProtKB/TrEMBL
  ENSRNOT00000066928 ENTREZGENE
  ENSRNOT00000066928.4 UniProtKB/Swiss-Prot
  ENSRNOT00000077671.2 UniProtKB/TrEMBL
  ENSRNOT00000091318.2 UniProtKB/TrEMBL
  ENSRNOT00000096488 ENTREZGENE
  ENSRNOT00000096488.1 UniProtKB/TrEMBL
  ENSRNOT00000105174 ENTREZGENE
  ENSRNOT00000105174.1 UniProtKB/TrEMBL
  ENSRNOT00000109388.1 UniProtKB/TrEMBL
  ENSRNOT00000109865 ENTREZGENE
  ENSRNOT00000109865.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Slo-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83731 UniProtKB/Swiss-Prot
NCBI Gene 83731 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1 UniProtKB/TrEMBL
  PTHR10027:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnma1 PhenoGen
PRINTS BKCHANNELA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005985 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K104_RAT UniProtKB/TrEMBL
  A0A0G2K8Q9_RAT UniProtKB/TrEMBL
  A0A8I5ZV96_RAT UniProtKB/TrEMBL
  A0A8I6A598 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASR2_RAT UniProtKB/TrEMBL
  A6KKU5 ENTREZGENE, UniProtKB/TrEMBL
  A6KKU6 ENTREZGENE, UniProtKB/TrEMBL
  A6KKU7 ENTREZGENE, UniProtKB/TrEMBL
  A6KKU8 ENTREZGENE, UniProtKB/TrEMBL
  F1LNC7 ENTREZGENE, UniProtKB/TrEMBL
  KCMA1_RAT UniProtKB/Swiss-Prot
  O08626 ENTREZGENE
  O55180 ENTREZGENE
  O88659 ENTREZGENE
  Q62976 ENTREZGENE
  Q7TMZ7 ENTREZGENE
  Q7TMZ8 ENTREZGENE
  Q7TQ55 ENTREZGENE
  Q7TQ56 ENTREZGENE
  Q7TQ57 ENTREZGENE
  Q9WUI3 ENTREZGENE
UniProt Secondary O08626 UniProtKB/Swiss-Prot
  O55180 UniProtKB/Swiss-Prot
  O88659 UniProtKB/Swiss-Prot
  Q7TMZ7 UniProtKB/Swiss-Prot
  Q7TMZ8 UniProtKB/Swiss-Prot
  Q7TQ55 UniProtKB/Swiss-Prot
  Q7TQ56 UniProtKB/Swiss-Prot
  Q7TQ57 UniProtKB/Swiss-Prot
  Q9WUI3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnma1  potassium calcium-activated channel subfamily M alpha 1  Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Data merged from RGD:1591969 737654 PROVISIONAL
2006-11-20 LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnma1  potassium large conductance calcium-activated channel, ubfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adrenal chromaffin cells 625439
gene_function potassium large conductance calcium-activated channel 625439
gene_process increases repetitive firing of chromaffin cells by minimizing action potential duration and speeding recovery of sodium channels from inactivation 625439
gene_regulation production of splice variants are differentially regulated by glucocorticoids and androgens in adrenal chromaffin cells 625439
gene_regulation channel acitivity is increased in a NO-mediated fashion 633138