RGD Reference Report - Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. - Rat Genome Database

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Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy.

Authors: Zhu, N  Eghbali, M  Helguera, G  Song, M  Stefani, E  Toro, L 
Citation: Zhu N, etal., FEBS Lett. 2005 Aug 29;579(21):4856-60.
RGD ID: 1581582
Pubmed: PMID:16102753   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2005.07.069   (Journal Full-text)

STREX alternative-exon adds to Slo channel a phosphorylation sequence that can invert protein kinase A (PKA) regulation from excitatory to inhibitory. Because pregnancy switches Slo responsiveness to PKA from inhibitory to excitatory, we hypothesized that STREX expression diminishes with pregnancy and is regulated by sex hormones. Different from total-rSlo, which is elevated around mid-pregnancy and decreases at term, STREX transcripts progressively decreased with pregnancy near 80% at term. STREX downregulation was mimicked by estrogen, and opposed by estrogen-receptor antagonist ICI 182,780 or progesterone (Pg). The regulation of STREX splicing directed by estrogen and Pg provides a mechanism for Slo's PKA-related phenotypic alteration with pregnancy.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnma1Ratresponse to estrogen  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnma1  (potassium calcium-activated channel subfamily M alpha 1)


Additional Information