Gstm2 (glutathione S-transferase mu 2) - Rat Genome Database

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Gene: Gstm2 (glutathione S-transferase mu 2) Rattus norvegicus
Analyze
Symbol: Gstm2
Name: glutathione S-transferase mu 2
RGD ID: 2756
Description: Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in several processes, including glutathione metabolic process; response to phenylpropanoid; and xenobiotic catabolic process. Located in cytosol. Part of protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM1 (glutathione S-transferase mu 1); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase M2; glutathione S-transferase Yb-2; glutathione S-transferase Yb2 subunit; glutathione S-transferase, mu 2; Glutathione-S-transferase mu type 2 (Yb2); Glutathione-S-transferase, mu type 2 (Yb2); GST 4-4; GST Yb2; GSTA4; GSTM2-2
RGD Orthologs
Human
Mouse
Bonobo
Alliance Genes
More Info more info ...
Candidate Gene For: Bp166
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,312,179 - 198,316,962 (-)NCBIGRCr8
mRatBN7.22195,624,015 - 195,628,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,544,426 - 195,628,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,266,686 - 203,271,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,148,808 - 201,153,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,965,761 - 195,970,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,778,041 - 210,782,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,247,260 - 230,251,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,549,022 - 203,553,380NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,270,799 - 188,275,157 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-allylphenol  (EXP)
2-butoxyethanol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-Chloronitrobenzene  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Propylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
andrographolide  (ISO)
angelica lactone  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
atrazine  (EXP,ISO)
bacitracin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzothiazole  (EXP)
benzylideneacetone  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bromosulfophthalein  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
cholic acid  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
clozapine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
coumarin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP,ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diazinon  (EXP)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
diquat  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
epoxiconazole  (EXP,ISO)
ethanol  (ISO)
ethoxyquin  (EXP,ISO)
eugenol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP)
Fenoprop  (EXP)
fenpyroximate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
Geniposide  (EXP)
gentamycin  (EXP)
gliotoxin  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
griseofulvin  (ISO)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP)
inulin  (ISO)
isomethyleugenol  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
lithocholic acid sulfate  (EXP)
mercury dibromide  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
metronidazole  (EXP)
microcystin  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nafenopin  (EXP)
naphthalene  (ISO)
nefazodone  (EXP,ISO)
neomycin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
prostaglandin H2  (ISO)
prostaglandins E  (ISO)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
Reactive blue 2  (EXP)
Rebamipide  (EXP)
riddelliine  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-hexylglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
streptozocin  (EXP)
styrene oxide  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tacrine  (EXP)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thiazoles  (EXP)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vancomycin  (EXP)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. 't Hoen PA, etal., Eur J Biochem. 2002 May;269(10):2574-83.
2. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Abu-Amero KK, etal., Br J Ophthalmol. 2009 Aug;93(8):1101-4. Epub 2009 Mar 13.
3. Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients. Abu-Amero KK, etal., Mol Vis. 2008 Mar 4;14:425-30.
4. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Alberti G, etal., Invest Ophthalmol Vis Sci. 1996 May;37(6):1167-73.
5. Glutathione S-transferase gene polymorphisms in presbycusis. Ates NA, etal., Otol Neurotol. 2005 May;26(3):392-7.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. Carless MA, etal., J Invest Dermatol. 2002 Dec;119(6):1373-8.
8. Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Chou FP, etal., Biochem Pharmacol. 2000 Sep 1;60(5):643-50.
9. An association between resistant hypertension and the null GSTM1 genotype. Cruz-Gonzalez I, etal., J Hum Hypertens. 2009 Aug;23(8):556-8. doi: 10.1038/jhh.2009.19. Epub 2009 Mar 12.
10. [Glutathione-S-transferase M1 genotype in patients with hepatocellular carcinoma]. Deng Z, etal., Zhonghua Zhong Liu Za Zhi. 2001 Nov;23(6):477-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration. Guven M, etal., Ophthalmic Res. 2011;46(1):31-7. doi: 10.1159/000321940. Epub 2011 Jan 5.
14. Detection of GST1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Harada S, etal., Hum Genet. 1992 Sep-Oct;90(1-2):62-4.
15. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Hirvonen A, etal., Cancer Res. 1995 Jul 15;55(14):2981-3.
16. Equilibrium folding of dimeric class mu glutathione transferases involves a stable monomeric intermediate. Hornby JA, etal., Biochemistry. 2000 Oct 10;39(40):12336-44.
17. Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes. Hovnik T, etal., Diabetes Care. 2009 Dec;32(12):2258-62. doi: 10.2337/dc09-0852. Epub 2009 Sep 14.
18. Analysis of the Glutathione S-transferase M1 gene using pyrosequencing and multiplex PCR--no evidence of association to glaucoma. Jansson M, etal., Exp Eye Res. 2003 Aug;77(2):239-43.
19. Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Juronen E, etal., Exp Eye Res. 2000 Nov;71(5):447-52.
20. Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. Kim JW, etal., Cancer. 2000 May 1;88(9):2082-91.
21. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
22. Differential induction of the expression of GST subunits by geniposide in rat hepatocytes. Kuo WH, etal., Pharmacology. 2004 Jan;70(1):15-22.
23. Rat glutathione S-transferases supergene family. Characterization of an anionic Yb subunit cDNA clone. Lai HC and Tu CP, J Biol Chem 1986 Oct 15;261(29):13793-9.
24. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. Lai HC, etal., J Biol Chem 1988 Aug 15;263(23):11389-95.
25. Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift. Lin CY, etal., Hear Res. 2009 Nov;257(1-2):8-15. doi: 10.1016/j.heares.2009.07.008. Epub 2009 Jul 28.
26. Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases. Luo JK, etal., Protein Sci 2002 Sep;11(9):2208-17.
27. Microarray analysis of rat chromosome 2 congenic strains. McBride MW, etal., Hypertension 2003 Mar;41(3 Pt 2):847-53.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism. Nicholl DJ, etal., Neurology. 1999 Oct 22;53(7):1415-21.
30. Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases. Nigam R, etal., J Pharmacol Exp Ther. 1996 Dec;279(3):1527-34.
31. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk. Northwood EL, etal., Pharmacogenet Genomics. 2010 May;20(5):315-26. doi: 10.1097/FPC.0b013e3283395c6a.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. Rao AV and Shaha C, FEBS Lett. 2001 Oct 26;507(2):174-80.
34. GOA pipeline RGD automated data pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Frequency of glutathione-S-transferase 1 gene deletion and its possible correlation with cataract formation. Sekine Y, etal., Exp Eye Res. 1995 Feb;60(2):159-63.
37. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
38. Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes. Stanley JA, etal., Free Radic Biol Med. 2013 Mar 5;61C:179-196. doi: 10.1016/j.freeradbiomed.2013.02.006.
39. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Strange RC, etal., Carcinogenesis. 1991 Jan;12(1):25-8.
40. Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium. Tsai YY, etal., Mol Vis. 2004 Jul 15;10:458-61.
41. Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment. Van Eyken E, etal., J Med Genet. 2007 Sep;44(9):570-8. Epub 2007 May 18.
42. Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. Wiegand H, etal., Cancer Genomics Proteomics. 2009 Mar-Apr;6(2):85-92.
43. Gene expression profiling of the ageing rat vibrissa follicle. Yang CL, etal., Br J Dermatol. 2005 Jul;153(1):22-8.
44. [Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers]. Yang M, etal., Wei Sheng Yan Jiu. 2005 Nov;34(6):647-9.
45. Is GST gene polymorphism a risk factor in developing exfoliation syndrome? Yilmaz A, etal., Curr Eye Res. 2005 Jul;30(7):575-81.
46. Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat. Zhou SG, etal., Mol Cell Biochem. 2008 Feb;309(1-2):99-107. Epub 2007 Nov 16.
Additional References at PubMed
PMID:2034681   PMID:2226415   PMID:2689439   PMID:3011803   PMID:3699019   PMID:3864155   PMID:8373352   PMID:8442656   PMID:8503873   PMID:12477932   PMID:15009649   PMID:16549767  
PMID:16624487   PMID:17023043   PMID:19056867   PMID:21046276   PMID:22406107   PMID:23376485   PMID:23533145   PMID:26316108   PMID:27612301  


Genomics

Comparative Map Data
Gstm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,312,179 - 198,316,962 (-)NCBIGRCr8
mRatBN7.22195,624,015 - 195,628,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,544,426 - 195,628,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,266,686 - 203,271,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,148,808 - 201,153,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,965,761 - 195,970,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,778,041 - 210,782,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,247,260 - 230,251,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,549,022 - 203,553,380NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,270,799 - 188,275,157 (-)NCBICelera
Cytogenetic Map2q34NCBI
GSTM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,668,057 - 109,683,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,668,022 - 109,709,551 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,210,679 - 110,226,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,012,214 - 110,019,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,922,732 - 109,929,949NCBI
Celera1108,475,704 - 108,491,676 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,098,937 - 108,114,955 (+)NCBIHuRef
CHM1_11110,325,465 - 110,359,901 (+)NCBICHM1_1
T2T-CHM13v2.01109,696,172 - 109,703,776 (+)NCBIT2T-CHM13v2.0
Gstm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,889,018 - 107,893,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,889,018 - 107,893,769 (-)EnsemblGRCm39 Ensembl
GRCm383107,981,702 - 107,986,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,981,702 - 107,986,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,784,620 - 107,789,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,109,758 - 108,114,495 (-)NCBIMGSCv36mm8
Celera3110,314,778 - 110,319,512 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
GSTM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01112,043,201 - 112,050,810 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11111,272,713 - 111,278,829 (+)NCBIpanpan1.1PanPan1.1panPan2

Variants

.
Variants in Gstm2
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:112
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000025939
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat

Markers in Region
RH143636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,624,474 - 195,624,587 (+)MAPPERmRatBN7.2
Rnor_6.02210,778,501 - 210,778,613NCBIRnor6.0
Rnor_5.02230,247,373 - 230,247,485UniSTSRnor5.0
RGSC_v3.42203,549,135 - 203,549,247UniSTSRGSC3.4
Celera2188,270,912 - 188,271,024UniSTS
RH 3.4 Map21390.5UniSTS
Cytogenetic Map2q34UniSTS
Gstm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,626,472 - 195,627,420 (+)MAPPERmRatBN7.2
Rnor_6.02210,780,499 - 210,781,446NCBIRnor6.0
Rnor_5.02230,249,371 - 230,250,318UniSTSRnor5.0
RGSC_v3.42203,551,133 - 203,552,080UniSTSRGSC3.4
Celera2188,272,910 - 188,273,857UniSTS
Cytogenetic Map2q34UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_177426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025689   ⟹   ENSRNOP00000025689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,566,703 - 195,572,203 (-)Ensembl
Rnor_6.0 Ensembl2210,720,720 - 210,726,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025746   ⟹   ENSRNOP00000025746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,579,566 - 195,584,350 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025800   ⟹   ENSRNOP00000025800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,567,235 - 195,572,203 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000025939   ⟹   ENSRNOP00000025939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,624,018 - 195,628,961 (-)Ensembl
Rnor_6.0 Ensembl2210,778,388 - 210,782,746 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077563   ⟹   ENSRNOP00000070866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,625,711 - 195,628,803 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080228   ⟹   ENSRNOP00000073859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,544,426 - 195,549,959 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081501   ⟹   ENSRNOP00000073172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,566,701 - 195,572,056 (-)Ensembl
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109587   ⟹   ENSRNOP00000084446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,579,566 - 195,584,350 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110922   ⟹   ENSRNOP00000092883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,544,426 - 195,628,803 (-)Ensembl
RefSeq Acc Id: NM_177426   ⟹   NP_803175
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,312,179 - 198,316,917 (-)NCBI
mRatBN7.22195,624,015 - 195,628,753 (-)NCBI
Rnor_6.02210,778,388 - 210,782,746 (-)NCBI
Rnor_5.02230,247,260 - 230,251,618 (-)NCBI
RGSC_v3.42203,549,022 - 203,553,380 (-)RGD
Celera2188,270,799 - 188,275,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_017590627   ⟹   XP_017446116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,312,179 - 198,316,962 (-)NCBI
mRatBN7.22195,624,015 - 195,628,774 (-)NCBI
Rnor_6.02210,778,041 - 210,782,807 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_803175   ⟸   NM_177426
- UniProtKB: P08010 (UniProtKB/Swiss-Prot),   B6DYQ2 (UniProtKB/TrEMBL),   A0A8L2QDS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446116   ⟸   XM_017590627
- Peptide Label: isoform X1
- UniProtKB: A6HUW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073172   ⟸   ENSRNOT00000081501
RefSeq Acc Id: ENSRNOP00000025939   ⟸   ENSRNOT00000025939
RefSeq Acc Id: ENSRNOP00000025689   ⟸   ENSRNOT00000025689
RefSeq Acc Id: ENSRNOP00000025800   ⟸   ENSRNOT00000025800
RefSeq Acc Id: ENSRNOP00000025746   ⟸   ENSRNOT00000025746
RefSeq Acc Id: ENSRNOP00000070866   ⟸   ENSRNOT00000077563
RefSeq Acc Id: ENSRNOP00000073859   ⟸   ENSRNOT00000080228
RefSeq Acc Id: ENSRNOP00000092883   ⟸   ENSRNOT00000110922
RefSeq Acc Id: ENSRNOP00000084446   ⟸   ENSRNOT00000109587
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ09-F1-model_v2 AlphaFold A0A0G2JZ09 1-215 view protein structure
AF-P08010-F1-model_v2 AlphaFold P08010 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691668
Promoter ID:EPDNEW_R2193
Type:initiation region
Name:Gstm2_1
Description:glutathione S-transferase mu 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,782,779 - 210,782,839EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2756 AgrOrtholog
BioCyc Gene G2FUF-51642 BioCyc
Ensembl Genes ENSRNOG00000018937 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000060939 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055021472 UniProtKB/Swiss-Prot
  ENSRNOG00060026017 UniProtKB/Swiss-Prot
  ENSRNOG00065023521 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025800.3 UniProtKB/TrEMBL
  ENSRNOT00000025939.5 UniProtKB/TrEMBL
  ENSRNOT00000077563.2 UniProtKB/TrEMBL
  ENSRNOT00000109587.1 UniProtKB/TrEMBL
  ENSRNOT00055036692 UniProtKB/Swiss-Prot
  ENSRNOT00060045029 UniProtKB/Swiss-Prot
  ENSRNOT00065040222 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1050.130 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24424 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 2 UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 6 UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C_3 UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gstm2 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018937 RatGTEx
  ENSRNOG00000060939 RatGTEx
  ENSRNOG00055021472 RatGTEx
  ENSRNOG00060026017 RatGTEx
  ENSRNOG00065023521 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ09_RAT UniProtKB/TrEMBL
  A0A8I6A1B0_RAT UniProtKB/TrEMBL
  A0A8L2QDS2 ENTREZGENE, UniProtKB/TrEMBL
  A6HUW9 ENTREZGENE, UniProtKB/TrEMBL
  B6DYQ2 ENTREZGENE, UniProtKB/TrEMBL
  G3V8H3_RAT UniProtKB/TrEMBL
  GSTM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gstm2  glutathione S-transferase mu 2  Gstm2  glutathione S-transferase M2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gstm2  glutathione S-transferase M2  Gstm2  glutathione S-transferase, mu 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gstm2  Glutathione-S-transferase, mu type 2 (Yb2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression reduced expression is associated with high blood pressure and oxidative stress in the stroke-prone spontaneously hypertensive (SHRSP) rat strain 631154
gene_function catalyzes the conjugation of electrophilic compounds to glutathione 631154
gene_process mediates cellular resistance against oxidative stress 631154
gene_product member of the family of glutathione S-transferases 631154