RGD Reference Report - Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients.

Authors: Abu-Amero, KK  Morales, J  Mohamed, GH  Osman, MN  Bosley, TM 
Citation: Abu-Amero KK, etal., Mol Vis. 2008 Mar 4;14:425-30.
RGD ID: 7488955
Pubmed: PMID:18334963   (View Abstract at PubMed)
PMCID: PMC2268859   (View Article at PubMed Central)

PURPOSE: Glutathione S-transferases (GSTs) are a family of enzymes that inactivate xenobiotics and endogenous end products formed as secondary metabolites during oxidative stress. In humans, GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) are associated with a variety of pathologic processes including certain ophthalmologic diseases. METHODS: We compared the prevalence of GSTT1 and GSTM1 deletion genotypes, which were determined by multiplex polymerase chain reaction, in 107 Arab patients with glaucoma (49 with primary open-angle glaucoma, 29 with pseudoexfoliation glaucoma, and 29 with primary angle-closure glaucoma) to 120 age, sex, and ethnically matched controls. RESULTS: All three GST polymorphisms were significantly more common in the entire glaucoma group (p<0.0167) than in controls. However, when patients were stratified by glaucoma type, the deletion genotype, T0M0, was not particularly associated with any type of glaucoma tested. The T1MO genotype was more common among patients with each type of glaucoma than among controls whereas T0M1 genotype was more common among pseudoexfoliation glaucoma (PEG) and primary open-angle glaucoma (POAG) patients than controls. CONCLUSIONS: The overall results indicate a possible variable association between various GSTT1 and GSTM1 genotypes and glaucoma in this population. Decreased GST function might interfere with the metabolism of oxidative intermediates and exacerbate the direct or indirect damaging effects of oxidative stress on the optic nerve. It is possible that these GST polymorphisms may be risk factors for glaucoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
angle-closure glaucoma susceptibilityIAGP 7488955DNA:deletion and haplotype:cds (human)RGD 
angle-closure glaucoma susceptibilityISOGSTM1 (Homo sapiens)7488955; 7488955DNA:deletion and haplotype:cds (human)RGD 
exfoliation syndrome susceptibilityIAGP 7488955DNA:deletion and haplotype:cds (human)RGD 
exfoliation syndrome susceptibilityISOGSTM1 (Homo sapiens)7488955; 7488955DNA:deletion and haplotype:cds (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal anterior chamber morphology susceptibilityIAGP 7488955DNA:deletion and haplotype:cds:RGD 
Abnormal anterior eye segment morphology susceptibilityIAGP 7488955DNA:deletion and haplotype:cdsRGD 
Increased cup-to-disc ratio susceptibilityIAGP 7488955DNA:deletion and haplotype:cdsRGD 
Ocular hypertension susceptibilityIAGP 7488955DNA:deletion and haplotype:cds:RGD 
Visual field defect susceptibilityIAGP 7488955DNA:deletion and haplotype:cdsRGD 
Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)

Objects referenced in this article
Gene Gstm2 glutathione S-transferase, mu 2 Mus musculus
Gene Gstm2 glutathione S-transferase mu 2 Rattus norvegicus

Additional Information