Kif5a (kinesin family member 5A) - Rat Genome Database

Name: Kif5a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Kif5a (kinesin family member 5A) Rattus norvegicus

Analyze

Symbol:

Kif5a

Name:

kinesin family member 5A

RGD ID:

1303035

Description:

Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 25; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

kinesin heavy chain isoform 5A; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain; NKHC

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KIF5A (kinesin family member 5A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Kif5a (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kif5a (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KIF5A (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KIF5A (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kif5a (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KIF5A (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KIF5A (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kif5a (kinesin family member 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC25A28 (solute carrier family 25 member 28)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	KIF5A (kinesin family member 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kif5a (kinesin family member 5A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kif5aa (kinesin family member 5A, a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Khc	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SMY1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	unc-116	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZC262.7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	kif5c	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kif5a	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	64,937,210 - 64,974,339 (-)	NCBI		GRCr8
mRatBN7.2	7	63,051,894 - 63,089,024 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,049,424 - 63,092,858 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	64,941,174 - 64,978,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,143,590 - 67,180,714 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	66,944,692 - 66,982,059 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	70,515,832 - 70,552,897 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,513,343 - 70,556,827 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,693,375 - 70,727,047 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,183,575 - 67,220,766 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	67,204,304 - 67,241,496 (-)	NCBI
Celera	7	60,193,348 - 60,229,555 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

amyotrophic lateral sclerosis type 25 (ISO)

asbestos-related lung carcinoma (ISO)

Auditory Neuropathy (ISO)

Charcot-Marie-Tooth disease axonal type 2U (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

choreatic disease (ISO)

demyelinating polyneuropathy (ISO)

epilepsy (ISO)

familial melanoma (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 10 (ISO)

INTERSTITIAL LUNG AND LIVER DISEASE (ISO)

multiple sclerosis (ISO)

Neonatal Intractable Myoclonus (ISO)

Nervous System Heredodegenerative Disorders (ISO)

neuropathy (ISO)

paraplegia (ISO)

peripheral nervous system disease (ISO)

prostate cancer (ISO)

rheumatoid arthritis (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,4-dithiothreitol (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acetamide (EXP)

ATP (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (EXP)

cadmium dichloride (ISO)

carmustine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

clobetasol (ISO)

copper(II) chloride (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethylene glycol bis(2-aminoethyl)tetraacetic acid (ISO)

fenamidone (ISO)

fenvalerate (EXP)

folic acid (ISO)

gentamycin (EXP)

GW 4064 (ISO)

L-1,4-dithiothreitol (ISO)

L-cysteine (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

lithium chloride (ISO)

magnesium dichloride (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

N-nitrosodiethylamine (ISO)

paracetamol (EXP)

PCB138 (ISO)

phenylmercury acetate (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tebuconazole (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (EXP)

venlafaxine hydrochloride (EXP)

vinclozolin (EXP)

zalcitabine (EXP)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterograde axonal protein transport (IMP)

anterograde dendritic transport of neurotransmitter receptor complex (IBA,IEA,ISO)

axon guidance (IBA)

cellular response to ethanol (IEP)

cellular response to nerve growth factor stimulus (IEP)

cerebral cortex development (IEP)

hippocampus development (IEP)

microtubule-based movement (IEA)

microtubule-based process (TAS)

neuron development (IEP)

response to rotenone (IEP)

retrograde neuronal dense core vesicle transport (IGI)

synaptic vesicle transport (IBA)

thalamus development (IEP)

vesicle-mediated transport (IEA,ISO,ISS)

Cellular Component

apical dendrite (IDA)

axon (IDA)

axon cytoplasm (IEA)

central region of growth cone (IDA)

ciliary rootlet (IEA,ISO)

cytoplasm (IEA,ISO)

cytoskeleton (IEA)

dendrite (IDA,ISO)

dendrite cytoplasm (IEA,ISO)

kinesin complex (IBA,IDA,TAS)

microtubule (IBA,IDA)

neuron projection (ISO)

neuronal cell body (IEA,ISO)

P-body (IDA)

perikaryon (IDA)

perinuclear region of cytoplasm (IEA)

postsynaptic cytosol (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA)

kinesin binding (IEA,ISO)

microtubule binding (IBA,IEA,ISO)

microtubule motor activity (IEA,TAS)

plus-end-directed microtubule motor activity (IBA)

protein binding (IPI,ISO)

protein-containing complex binding (IPI)

scaffold protein binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondria transport pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.	Alcina A, etal., Genes Immun. 2010 Jul;11(5):439-45. doi: 10.1038/gene.2010.30. Epub 2010 May 27.
2.	Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus.	Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
3.	Hereditary spastic paraplegia: a novel mutation and expansion of the phenotype variability in SPG10.	Carosi L, etal., J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):702-4. doi: 10.1136/jnnp-2014-308625. Epub 2014 Oct 28.
4.	Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population.	Danoy P, etal., Ann Rheum Dis. 2011 Oct;70(10):1793-7. doi: 10.1136/ard.2010.144576. Epub 2011 Jul 21.
5.	Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia.	Fichera M, etal., Neurology. 2004 Sep 28;63(6):1108-10.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.	Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
9.	Replication of European rheumatoid arthritis loci in a Pakistani population.	Jalil SF, etal., J Rheumatol. 2013 Apr;40(4):401-7. doi: 10.3899/jrheum.121050. Epub 2013 Feb 1.
10.	Axonal transport deficit in a KIF5A( -/- ) mouse model.	Karle KN, etal., Neurogenetics. 2012 May;13(2):169-79. doi: 10.1007/s10048-012-0324-y. Epub 2012 Apr 1.
11.	Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis.	Kuzma-Kozakiewicz M, etal., Neurodegener Dis. 2013;12(2):71-80. doi: 10.1159/000339529. Epub 2012 Sep 21.
12.	Regulation of mitochondrial transport in neurons.	Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
13.	The mitochondrial and autosomal mutation landscapes of prostate cancer.	Lindberg J, etal., Eur Urol. 2013 Apr;63(4):702-8. doi: 10.1016/j.eururo.2012.11.053. Epub 2012 Dec 5.
14.	Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing.	Lynch DS, etal., Eur J Hum Genet. 2016 Jun;24(6):857-63. doi: 10.1038/ejhg.2015.200. Epub 2015 Sep 16.
15.	Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons.	Ma B, etal., Sci Rep. 2011;1:140. Epub 2011 Nov 3.
16.	Beta-dystrobrevin interacts directly with kinesin heavy chain in brain.	Macioce P, etal., J Cell Sci 2003 Dec 1;116(Pt 23):4847-56.
17.	Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.	Melo TQ, etal., Cell Mol Neurobiol. 2013 Apr;33(3):327-35. doi: 10.1007/s10571-012-9898-z. Epub 2012 Dec 22.
18.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
19.	A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness.	Muglia M, etal., J Neurol Sci. 2014 Aug 15;343(1-2):218-20. doi: 10.1016/j.jns.2014.05.063. Epub 2014 Jun 5.
20.	Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.	Nakajima K, etal., Neuron. 2012 Dec 6;76(5):945-61. doi: 10.1016/j.neuron.2012.10.012.
21.	Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity.	Oh JY, etal., J Cell Sci. 2013 May 1;126(Pt 9):2114-23. doi: 10.1242/jcs.125690. Epub 2013 Mar 13.
22.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
23.	A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10).	Reid E, etal., Am J Hum Genet. 2002 Nov;71(5):1189-94. Epub 2002 Sep 24.
24.	GOA pipeline	RGD automated data pipeline
25.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
27.	Chronic alcohol exposure affects the cell components involved in membrane traffic in neuronal dendrites.	Romero AM, etal., Neurotox Res. 2015 Jan;27(1):43-54. doi: 10.1007/s12640-014-9484-x. Epub 2014 Jul 15.
28.	SPG10 is a rare cause of spastic paraplegia in European families.	Schüle R, etal., J Neurol Neurosurg Psychiatry. 2008 May;79(5):584-7. doi: 10.1136/jnnp.2007.137596. Epub 2008 Feb 1.
29.	DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2.	Shinoda T, etal., J Neurosci. 2007 Jan 3;27(1):4-14.
30.	c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner.	Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
31.	DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.	Taya S, etal., J Neurosci. 2007 Jan 3;27(1):15-26.
32.	Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers.	Tooker BC, etal., Biomarkers. 2011 Mar;16(2):181-91. doi: 10.3109/1354750X.2010.543289. Epub 2011 Jan 14.
33.	Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells.	Vignali G, etal., Eur J Neurosci. 1996 Mar;8(3):536-44.
34.	Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat.	Vignali G, etal., J Neurochem. 1997 Nov;69(5):1840-9.

Additional References at PubMed

PMID:7514426	PMID:11986669	PMID:15644324	PMID:16018997	PMID:16301330	PMID:17360631	PMID:18539120	PMID:19946888	PMID:20152113	PMID:21048148	PMID:21411631	PMID:21976701
PMID:22539840	PMID:28886967	PMID:29476059	PMID:30053369	PMID:31904090	PMID:34348158	PMID:36214718	PMID:36862119

Genomics

Comparative Map Data

Kif5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	64,937,210 - 64,974,339 (-)	NCBI		GRCr8
mRatBN7.2	7	63,051,894 - 63,089,024 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,049,424 - 63,092,858 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	64,941,174 - 64,978,298 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,143,590 - 67,180,714 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	66,944,692 - 66,982,059 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	70,515,832 - 70,552,897 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,513,343 - 70,556,827 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,693,375 - 70,727,047 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,183,575 - 67,220,766 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	67,204,304 - 67,241,496 (-)	NCBI
Celera	7	60,193,348 - 60,229,555 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

KIF5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	57,550,044 - 57,586,633 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	57,546,026 - 57,586,633 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	57,943,827 - 57,980,416 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,230,114 - 56,264,821 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	56,230,113 - 56,264,821	NCBI
Celera	12	57,599,677 - 57,634,382 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,981,745 - 55,016,257 (+)	NCBI		HuRef
CHM1_1	12	57,911,685 - 57,946,386 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	57,518,283 - 57,554,872 (+)	NCBI		T2T-CHM13v2.0

Kif5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,061,564 - 127,102,217 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,061,565 - 127,099,217 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	127,225,695 - 127,266,348 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,225,696 - 127,263,348 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,662,751 - 126,700,419 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	126,628,648 - 126,666,029 (-)	NCBI		MGSCv36	mm8
Celera	10	129,618,645 - 129,655,868 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	74.5	NCBI

Kif5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,287,111 - 5,310,962 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,264,274 - 5,310,962 (+)	NCBI	ChiLan1.0	ChiLan1.0

KIF5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	36,754,420 - 36,791,175 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	36,751,196 - 36,787,946 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	31,340,201 - 31,376,849 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	31,599,376 - 31,635,677 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,599,376 - 31,635,327 (-)	Ensembl	panpan1.1		panPan2

KIF5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,637,007 - 1,666,790 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,636,932 - 1,664,767 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,700,232 - 1,729,959 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	1,646,391 - 1,676,129 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	1,646,235 - 1,676,121 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	1,624,071 - 1,653,916 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,865,983 - 1,895,693 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,990,984 - 2,020,928 (+)	NCBI		UU_Cfam_GSD_1.0

Kif5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,137,419 - 57,172,692 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	1,697,492 - 1,732,832 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	1,697,531 - 1,730,376 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KIF5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,816,854 - 22,851,973 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,813,617 - 22,851,976 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

KIF5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,458,795 - 53,493,801 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	192,467,068 - 192,505,360 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kif5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	10,375,774 - 10,409,566 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	10,375,132 - 10,409,575 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kif5a
159 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	595
Count of miRNA genes:	263
Interacting mature miRNAs:	334
Transcripts:	ENSRNOT00000007721
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	47251783	65728867	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat

Markers in Region

BF388221

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,050,720 - 63,050,898 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	70,514,659 - 70,514,836	NCBI	Rnor6.0
Rnor_5.0	7	70,692,202 - 70,692,379	UniSTS	Rnor5.0
RGSC_v3.4	7	67,182,402 - 67,182,579	UniSTS	RGSC3.4
Celera	7	60,192,175 - 60,192,352	UniSTS
Cytogenetic Map	7	q22	UniSTS

Kif5a

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,056,621 - 63,058,321 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	70,520,496 - 70,522,195	NCBI	Rnor6.0
Rnor_5.0	7	70,694,646 - 70,696,345	UniSTS	Rnor5.0
RGSC_v3.4	7	67,188,357 - 67,190,056	UniSTS	RGSC3.4
Celera	7	60,196,964 - 60,198,663	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									72		3
Low	3	40	30	14	19	14	8	11	2	35	38	11	8
Below cutoff		3	27	27		27

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_212523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY535015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007721 ⟹ ENSRNOP00000007721

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,049,424 - 63,092,858 (-)	Ensembl
Rnor_6.0 Ensembl	7	70,513,343 - 70,556,827 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080594 ⟹ ENSRNOP00000071539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,049,424 - 63,089,064 (-)	Ensembl
Rnor_6.0 Ensembl	7	70,515,832 - 70,552,897 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112903 ⟹ ENSRNOP00000095825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,049,424 - 63,089,064 (-)	Ensembl

RefSeq Acc Id:

NM_212523 ⟹ NP_997688

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	64,937,210 - 64,974,339 (-)	NCBI
mRatBN7.2	7	63,051,894 - 63,089,024 (-)	NCBI
Rnor_6.0	7	70,515,832 - 70,552,897 (-)	NCBI
Rnor_5.0	7	70,693,375 - 70,727,047 (-)	NCBI
RGSC_v3.4	7	67,183,575 - 67,220,766 (-)	RGD
Celera	7	60,193,348 - 60,229,555 (-)	RGD

Sequence:

show sequence

CAAAAGCCCAGGTCGCCCGCATCCAGTGCCGCAGGACACCAAAAGCGCACCTTCGCCTGGGCAT
CCCAGCTGCTCCCTTGGCCTCAGCGACAGATCACCTGTCCTCCGCCTCAACCCCAACCCAGCGC
TCCCTTCCTCCGGAGCACACGCTACCGTTGCAGCCGGAGACGCGCCCCAGCCCCTCGACGTCGA
CCACCATGGCGGAGACCAATAACGAATGCAGCATCAAGGTGCTTTGCCGATTTCGGCCCCTGAA
CCAGGCCGAGATCCTGCGGGGGGACAAGTTCATCCCCATTTTCCAAGGGGACGACAGCGTCATT
ATTGGGGGAAAGCCATATGTCTTCGACCGTGTATTCCCCCCAAACACGACTCAGGAGCAGGTTT
ACCACGCCTGTGCCATGCAGATCGTCAAAGACGTCCTTGCTGGCTACAACGGCACAATTTTTGC
TTATGGACAGACATCCTCAGGGAAAACGCACACCATGGAGGGAAAGCTGCACGACCCTCAGCTC
ATGGGCATCATTCCCCGGATCGCCCGAGACATCTTCAACCACATCTACTCCATGGATGAGAACC
TTGAGTTCCACATTAAGGTGTCTTACTTTGAGATTTACCTGGATAAGATCCGTGACCTTTTGGA
TGTGACCAAGACAAACCTGTCTGTGCATGAGGACAAAAACCGGGTGCCGTTTGTCAGGGGTTGT
ACCGAACGCTTTGTGTCCAGCCCAGAGGAGATTCTGGATGTGATTGATGAGGGGAAGTCGAACC
GTCACGTTGCCGTCACCAACATGAATGAGCACAGCTCTCGGAGTCACAGCATCTTCCTCATCAA
CATCAAGCAGGAGAACATAGAGACGGAGCAGAAGCTCAGCGGGAAACTGTACCTTGCGGATCTG
GCCGGAAGCGAGAAGGTCAGCAAGACAGGAGCAGAGGGAGCCGTTCTGGATGAGGCAAAGAATA
TCAATAAGTCGCTGTCGGCCCTGGGGAATGTGATCTCTGCTCTGGCCGAGGGCACTAAAAGCTA
CGTGCCGTACCGTGACAGCAAAATGACGAGGATTCTCCAGGACTCTCTGGGAGGGAACTGCAGG
ACCACCATGTTCATCTGCTGCTCACCATCCAGCTACAATGACGCAGAGACCAAGTCCACACTCA
TGTTTGGGCAGCGGGCAAAGACCATCAAGAACACTGCCTCAGTGAATCTGGAGTTGACTGCTGA
GCAATGGAAGAAGAAATATGAGAAGGAGAAGGAGAAGACCAAGGCCCAGAAGGAGACAATTGCG
AAGCTGGAGGCTGAGCTTAGCCGGTGGCGCAATGGAGAGAATGTGCCTGAGACTGAGCGCCTGG
CTGGAGAGGACTCAGCTCTGGCAGCCGAGATCTGTGAGGAGACCCCTGTGAATGACAACTCATC
CATCGTGGTACGCATCGCACCGGAGGAAAGGCAGAAATACGAGGAAGAGATCCGCCGTCTCTAC
AAGCAGCTCGACGACAAGGATGATGAGATCAACCAGCAGAGCCAACTCATTGAGAAGCTGAAGC
AGCAGATGCTGGACCAGGAAGAGCTGCTAGTGTCCACTCGGGGAGACAATGAGAAGGTCCAGCG
GGAGCTGAGCCACCTGCAGTCTGAGAACGATGCCGCGAAGGAGGAGGTGAAGGAAGTGTTGCAG
GCCCTGGAGGAGCTGGCAGTCAACTATGACCAGAAGTCCCAGGAGGTGGAGGAGAAGAGCCAGC
AGAACCAGCTGCTGGTGGATGAGCTGTCCCAGAAAGTGGCCACCATGCTGTCCCTGGAGTCTGA
GCCACAGCGGCTCCAGGAAGTCAGTGGACACCAGCGAAAACGGATCGCTGAGGTGCTGAATGGA
CTGATGAAGGACCTGAGTGAGTTCAGTGTCATCGTGGGCAACGGCGAGATTAAGCTGCCTGTGG
AGATCAGTGGGGCCATCGAAGAGGAGTTCACGGTGGCCCGACTCTACATCAGCAAGATCAAGTC
AGAGGTGAAGTCCGTGGTTAAGCGATGCCGGCAGCTGGAGAACCTCCAAGTGGAGTGTCATCGC
AAGATGGAGGTGACCGGTAGGGAGCTGTCGTCTTGCCAGCTGCTCATCTCACAGCACGAGGCCA
AGATCCGTTCGCTCACGGAATACATGCAGACTGTGGAGTTGAAGAAGCGGCACCTGGAAGAGTC
CTATGACTCCCTGAGCGATGAGCTAGCCAAGCTCCAGGCGCAGGAAACTGTACACGAGGTAGCT
CTGAAAGACAAGGAGCCAGATACGCAGGATGCGGAGGAGGTGAAGAAGGCCCTGGAACTACAGA
TGGAGAATCATCGTGAGGCCCATCACCGGCAGCTGGCCCGCCTCCGAGATGAGATCAATGAGAA
ACAGAAGACCATTGATGAGCTTAAAGACCTGGACCAGAAGCTCCAGTTAGAGCTGGAGAAGCTT
CAGGCTGATTACGAGAGACTGAAGAACGAAGAGAACGAGAAGAGTGCCAAGCTCCAGGAGCTGA
CATTTCTGTATGAGCGGCATGAGCAGTCCAAGCAGGACCTCAAGGGGCTGGAGGAGACAGTTGC
CCGTGAACTCCAGACCCTCCACAACCTGCGCAAGCTGTTCGTTCAAGACGTCACGACTCGAGTC
AAGAAAAGTGCAGAAATGGAGCCCGAGGACAGTGGGGGGATTCATTCCCAAAAGCAGAAGATCT
CCTTTCTTGAGAACAACCTGGAACAGCTTACAGAGGTTCACAAACAGCTGGTACGTGACAATGC
AGATCTGCGTTGTGAGCTTCCTAAATTGGAAAAACGACTTCGGGCTACGGCTGAGAGAGTTAAG
GCCCTGGAGGGTGCACTGAAGGAGGCCAAGGAGGGCGCTATGAAGGACAAGCGCCGATACCAGC
AGGAGGTGGACCGCATCAAGGAAGCTGTGCGGTACAAGAGCTCTGGCAAGCGGGGCCACTCTGC
CCAGATTGCTAAGCCTGTGAGGCCCGGCCACTATCCTGCCTCCTCACCCACCAACCCCTACGGT
ACCCGGAGTCCCGAGTGTATCAGCTACACCAACAACCTCTTCCAGAACTACCAGAACCTGCACC
TGCAGGCTGCGCCTAGCTCCACCTCAGACGTGTACTTTGCCAGCAACGGAGCCACATCTGTTGC
CCCCTTGGCTTCCTACCAGAAGGCCAACACGGACAATGGAAACGCCACAGATATCAACGACAAC
AGGAGTGACCTGCCCTGCGGCTATGAGGCTGAGGACCCAGCCAAGCTTTTCCCTCTCCACCAAG
AGACGGCAGCCAGCTAACTCCCAATCCTGGCTGCATATCTGCACTTTCAGTTTCTAAGAGGGAC
TGAGGCCTCTTCTCTCAGCATGCTGCAAAACCTGTGGTCTCTGACACTAACTCCCTCCCCAGCC
CGTGTCGTTGGACTGTTTGATGTCTCCTTCTACTCTGTATCTCTTTGTACCCTGTATCTATTTA
TCAGAAGCTGCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_997688	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS45402	(Get FASTA)	NCBI Sequence Viewer
	EDM16486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007721.4
	ENSRNOP00000071539
	ENSRNOP00000071539.1
	ENSRNOP00000095825.1
GenBank Protein	Q6QLM7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_997688 ⟸ NM_212523

- UniProtKB:

Q6QLM7 (UniProtKB/Swiss-Prot), A0A0G2K0Q2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYH
ACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE
FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVRGCTERFVSSPEEILDVIDEGKSNRH
VAVTNMNEHSSRSHSIFLINIKQENIETEQKLSGKLYLADLAGSEKVSKTGAEGAVLDEAKNIN
KSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMF
GQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAG
EDSALAAEICEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQ
MLDQEELLVSTRGDNEKVQRELSHLQSENDAAKEEVKEVLQALEELAVNYDQKSQEVEEKSQQN
QLLVDELSQKVATMLSLESEPQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEI
SGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKI
RSLTEYMQTVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDAEEVKKALELQME
NHREAHHRQLARLRDEINEKQKTIDELKDLDQKLQLELEKLQADYERLKNEENEKSAKLQELTF
LYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISF
LENNLEQLTEVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQE
VDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNNLFQNYQNLHLQ
AAPSSTSDVYFASNGATSVAPLASYQKANTDNGNATDINDNRSDLPCGYEAEDPAKLFPLHQET
AAS

hide sequence

RefSeq Acc Id:

ENSRNOP00000071539 ⟸ ENSRNOT00000080594

RefSeq Acc Id:

ENSRNOP00000007721 ⟸ ENSRNOT00000007721

RefSeq Acc Id:

ENSRNOP00000095825 ⟸ ENSRNOT00000112903

Protein Domains

Kinesin motor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6QLM7-F1-model_v2	AlphaFold	Q6QLM7	1-1027	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695254

Promoter ID:

EPDNEW_R5779

Type:

initiation region

Name:

Kif5a_1

Description:

kinesin family member 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,552,915 - 70,552,975	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303035	AgrOrtholog
BioCyc Gene	G2FUF-33757	BioCyc
Ensembl Genes	ENSRNOG00000005299	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007721.6	UniProtKB/TrEMBL
	ENSRNOT00000080594	ENTREZGENE
	ENSRNOT00000080594.2	UniProtKB/TrEMBL
	ENSRNOT00000112903.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.850.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.1590	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Kinesin-like_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_CS	UniProtKB/TrEMBL
	Kinesin_motor_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinesin_motor_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:314906	UniProtKB/Swiss-Prot
NCBI Gene	314906	ENTREZGENE
PANTHER	CENTROMERE PROTEIN E	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KINESIN MOTOR DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Kinesin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Kif5a	PhenoGen
PRINTS	KINESINHEAVY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	KINESIN_MOTOR_1	UniProtKB/TrEMBL
	KINESIN_MOTOR_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005299	RatGTEx
SMART	KISc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K0Q2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6APJ1_RAT	UniProtKB/TrEMBL
	A6HQT6_RAT	UniProtKB/TrEMBL
	F1M8F2_RAT	UniProtKB/TrEMBL
	KIF5A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Kif5a	kinesin family member 5A			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Kif5a	kinesin family member 5A			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations