Sod2 (superoxide dismutase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Sod2 (superoxide dismutase 2) Rattus norvegicus
Analyze
Symbol: Sod2
Name: superoxide dismutase 2
RGD ID: 3732
Description: Enables several functions, including manganese ion binding activity; oxygen binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to ethanol; hydrogen peroxide biosynthetic process; and negative regulation of membrane hyperpolarization. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2); PARTICIPATES IN hypertension pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (+)-sesamin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: manganese superoxide dismutase; mitochondrial superoxide dismutase 2; MnSOD; Superoxide dimutase 2 mitochondrial; Superoxide dimutase 2, mitochondrial; Superoxide dismutase 2 mitochondrial; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm22
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 124 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratabdominal aortic aneurysm  IEP 1625699mRNA and protein:increased expression:aortaRGD 
Sod2Ratacute myeloid leukemia  ISOSOD2 (Homo sapiens)11035286protein:increased expression:serumRGD 
Sod2Ratacute myeloid leukemia disease_progressionISOSOD2 (Homo sapiens)11035289 RGD 
Sod2Ratadult respiratory distress syndrome  IEP 11035305mRNA:increased expression:lungRGD 
Sod2Ratalcoholic liver cirrhosis susceptibilityISOSOD2 (Homo sapiens)11060603DNA:SNP: : 47T>C(human)RGD 
Sod2RatAlcoholic Liver Diseases treatmentISOSod2 (Mus musculus)27095880 RGD 
Sod2RatAlzheimer's disease  ISOSOD2 (Homo sapiens)1579972 RGD 
Sod2Ratanemia  ISOSod2 (Mus musculus)1581262 RGD 
Sod2RatAortic Calcification  IEP 11038653associated with Renal Insufficiency more ...RGD 
Sod2Ratasthma  ISOSOD2 (Homo sapiens)1581231 RGD 
Sod2RatBacteremia  ISOSod2 (Mus musculus)26923958mRNA:increased expression:liver:RGD 
Sod2Ratbilirubin metabolic disorder treatmentISOSOD2 (Homo sapiens)11060605associated with acute lymphoblastic leukemia and DNA:SNP: :(rs4880)(human)RGD 
Sod2Ratbladder neck obstruction  IEP 7175518 RGD 
Sod2Ratbrain edema  ISOSOD2 (Homo sapiens)329969876mRNA:increased expression:neocortex and Pyramidal cells (human)RGD 
Sod2RatBrain Injuries  ISOSod2 (Mus musculus)1581214 RGD 
Sod2Ratbrain ischemia  ISOSod2 (Mus musculus)1625695 RGD 
Sod2Ratbreast cancer  ISOSOD2 (Homo sapiens)1581240 RGD 
Sod2RatBreast Neoplasms  ISOSOD2 (Homo sapiens)1581248 RGD 
Sod2RatCardiac Arrhythmias  IDA 1581234 RGD 
Sod2Ratcardiomyopathy  ISOSOD2 (Homo sapiens)1580836associated with hemochromatosis and DNA:polymorphism: :p.A16V (human)RGD 
1 to 20 of 124 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Rat3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome  ISOSOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria with deafness more ...ClinVarPMID:15220921 more ...
Sod2Ratdiabetic angiopathy  ISOSOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Microvascular complications of diabetes more ...ClinVarPMID:10425186 more ...
Sod2Ratprimary ciliary dyskinesia 32  ISOSOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesia 32ClinVarPMID:28492532
1 to 20 of 128 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratabdominal aortic aneurysm  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17196988
Sod2RatAcute Coronary Syndrome  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21751358
Sod2Ratacute kidney tubular necrosis  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:19917352
Sod2Ratadenocarcinoma  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12907644
Sod2Ratadrenoleukodystrophy  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16319717
Sod2Ratadult respiratory distress syndrome  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Sod2RatAlbuminuria  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17942768
Sod2Ratalcoholic liver cirrhosis  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19731237
Sod2RatAlzheimer's disease  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19374891
Sod2Ratamyotrophic lateral sclerosis  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8866423
Sod2Ratanaplastic thyroid carcinoma  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15887859
Sod2Ratanemia  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20800516
Sod2Rataortic disease  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25101153
Sod2RatArsenic Poisoning  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16835338
Sod2Ratasphyxia neonatorum  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17963755
Sod2Ratatherosclerosis  ISOSOD2 (Homo sapiens)11554173CTD more ...CTDPMID:12677255 and PMID:20720404
Sod2Ratautoimmune disease  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21850155
Sod2RatBrain Injuries  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:24462953
Sod2Ratbrain ischemia  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15060315 more ...
Sod2RatBrain Neoplasms  ISOSOD2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21749277
1 to 20 of 128 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratamyotrophic lateral sclerosis type 1  ISSSod2 (Mus musculus)13592920OMIM:105400MouseDO 
Sod2RatCanavan disease  ISSSod2 (Mus musculus)13592920OMIM:271900MouseDO 
Sod2Ratcongestive heart failure  ISSSod2 (Mus musculus)13592920 MouseDO 
Sod2Ratdilated cardiomyopathy  ISSSod2 (Mus musculus)13592920 MouseDO 
Sod2RatLeigh disease  ISSSod2 (Mus musculus)13592920OMIM:220111 more ...MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratdiabetic angiopathy  ISOSOD2 (Homo sapiens)7240710 OMIM 

1 to 20 of 1599 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Rat(+)-albicanol multiple interactionsISOSod2 (Mus musculus)6480464albicanol inhibits the reaction [Galactose results in decreased expression of SOD2 protein]CTDPMID:33761044
Sod2Rat(+)-catechin multiple interactionsISOSOD2 (Homo sapiens)6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 proteinCTDPMID:26187476
Sod2Rat(+)-catechin multiple interactionsISOSod2 (Mus musculus)6480464[Catechin co-treated with Benzo(a)pyrene] results in increased expression of SOD2 mRNACTDPMID:28533128
Sod2Rat(+)-catechin increases activityISOSOD2 (Homo sapiens)6480464Catechin analog results in increased activity of SOD2 proteinCTDPMID:26187476
Sod2Rat(+)-epicatechin-3-O-gallate multiple interactionsISOSOD2 (Homo sapiens)6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 proteinCTDPMID:26187476
Sod2Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of SOD2 proteinCTDPMID:20446108
Sod2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SOD2 mRNA]CTDPMID:31150632
Sod2Rat(+)-sesamin multiple interactionsEXP 64804646-chloro-2 more ...CTDPMID:24211423
Sod2Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA] and taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]CTDPMID:32525071 and PMID:36198370
Sod2Rat(-)-cotinine multiple interactionsEXP 6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 proteinCTDPMID:29617909
Sod2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSOD2 (Homo sapiens)6480464[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] results in increased activity of SOD2 protein more ...CTDPMID:16115949 more ...
Sod2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSod2 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]CTDPMID:36056792
Sod2Rat(-)-epigallocatechin 3-gallate increases expressionISOSod2 (Mus musculus)6480464epigallocatechin gallate results in increased expression of SOD2 mRNA and epigallocatechin gallate results in increased expression of SOD2 proteinCTDPMID:29175576 and PMID:36056792
Sod2Rat(-)-epigallocatechin 3-gallate decreases expressionISOSod2 (Mus musculus)6480464epigallocatechin gallate results in decreased expression of SOD2 mRNACTDPMID:29175576
Sod2Rat(-)-epigallocatechin 3-gallate increases activityISOSOD2 (Homo sapiens)6480464epigallocatechin gallate results in increased activity of SOD2 proteinCTDPMID:26187476
Sod2Rat(-)-epigallocatechin 3-gallate affects activityISOSod2 (Mus musculus)6480464epigallocatechin gallate affects the activity of SOD2 proteinCTDPMID:25955525
Sod2Rat(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of and affects the activity of SOD2 protein]CTDPMID:20666448
Sod2Rat(1->4)-beta-D-glucan multiple interactionsISOSod2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SOD2 mRNACTDPMID:36331819
Sod2Rat(E)-cinnamyl alcohol increases expressionISOSOD2 (Homo sapiens)6480464cinnamyl alcohol results in increased expression of SOD2 mRNACTDPMID:20566472
Sod2Rat(R)-adrenaline multiple interactionsISOSOD2 (Homo sapiens)64804646-hydroxy-2 more ...CTDPMID:11163531

1 to 20 of 1599 rows

Biological Process
1 to 20 of 80 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857129 more ...RGDPMID:16873728
Sod2Ratapoptotic mitochondrial changes acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:11226230RGDPMID:11226230
Sod2Ratcellular response to ethanol  IEP 2317384 RGD 
Sod2Ratcellular response to oxidative stress involved_inISSUniProtKB:P041791600115GO_REF:0000024UniProtGO_REF:0000024
Sod2Ratcellular response to oxidative stress involved_inISOSOD2 (Homo sapiens)1624291 PMID:14980699RGDPMID:14980699
Sod2Ratdetection of oxygen acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:11156968RGDPMID:11156968
Sod2Raterythrophore differentiation acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:15205258RGDPMID:15205258
Sod2Ratglutathione metabolic process acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:10049502RGDPMID:10049502
Sod2Ratheart development acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:7493016RGDPMID:7493016
Sod2Rathemopoiesis acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857480 PMID:16219542 and PMID:8790408RGDPMID:16219542 and PMID:8790408
Sod2Rathydrogen peroxide biosynthetic process  IDA 2291946 RGD 
Sod2Rathydrogen peroxide metabolic process  IMP 1580833 RGD 
Sod2Ratintracellular oxygen homeostasis involved_inISOSOD2 (Homo sapiens)1624291 PMID:16179351RGDPMID:16179351
Sod2Ratintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857480 PMID:15642323RGDPMID:15642323
Sod2Ratintrinsic apoptotic signaling pathway in response to oxidative stress acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857480 PMID:15642323RGDPMID:15642323
Sod2Ratliver development acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:2177602 more ...RGDPMID:17367743
Sod2Ratlocomotory behavior acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857480 PMID:8790408RGDPMID:8790408
Sod2Ratmitochondrion organization acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 more ...RGDPMID:11527927 more ...
Sod2Ratmulticellular organismal-level iron ion homeostasis acts_upstream_of_or_withinISOSod2 (Mus musculus)1624291MGI:1857344 PMID:15205258RGDPMID:15205258
Sod2Ratnegative regulation of apoptotic process  IMP 1581094 RGD 
1 to 20 of 80 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Ratmitochondrial matrix located_inISOSOD2 (Homo sapiens)1624291 PMID:23168492RGDPMID:23168492
Sod2Ratmitochondrial nucleoid  IDA 2306615 RGD 
Sod2Ratmitochondrion located_inISOSOD2 (Homo sapiens)1624291 PMID:12551919RGDPMID:12551919
Sod2Ratmitochondrion is_active_inIBACGD:CAL0000191321 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod2Ratmitochondrion located_inISOSod2 (Mus musculus)1624291 PMID:11583975 more ...RGDPMID:11583975 more ...
Sod2Ratmitochondrion located_inISOSOD2 (Homo sapiens) and UniProtKB:P04179-11624291 RGDGO_REF:0000052

Molecular Function
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2RatDNA binding  IDA 2306615 RGD 
Sod2Ratenzyme binding  IPISirt3 (Rattus norvegicus)8158103 RGD 
Sod2Ratidentical protein binding  IPISod2 (Rattus norvegicus)2317389homooligomerizationRGD 
Sod2Ratidentical protein binding enablesISOSOD2 (Homo sapiens)1624291UniProtKB:P04179 more ...RGDPMID:19822147 and PMID:21988832
Sod2Ratmanganese ion binding  IDA 2317389 RGD 
Sod2Ratmanganese ion binding enablesIBAPANTHER:PTN004256454 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod2Ratmanganese ion binding enablesISOSOD2 (Homo sapiens)1624291 PMID:19265433RGDPMID:19265433
Sod2Ratmanganese ion binding enablesISSUniProtKB:P041791600115GO_REF:0000024UniProtGO_REF:0000024
Sod2Ratoxidoreductase activity enablesISOSod2 (Mus musculus)1624291 PMID:15205258RGDPMID:15205258
Sod2Ratoxygen binding  IDA 2291946 RGD 
Sod2Ratoxygen binding  IDA 2291939 RGD 
Sod2Ratprotein binding enablesISOSOD2 (Homo sapiens)1624291UniProtKB:Q8NHQ1 and PMID:32296183RGDPMID:32296183
Sod2Ratprotein binding enablesISOSod2 (Mus musculus)1624291UniProtKB:P02340 more ...RGDPMID:21909133
Sod2Ratsuperoxide dismutase activity  IDA 2291946 RGD 
Sod2Ratsuperoxide dismutase activity enablesISOSod2 (Mus musculus)1624291MGI:1857344 more ...RGDPMID:12176043 more ...
Sod2Ratsuperoxide dismutase activity enablesIBACGD:CAL0000181372 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod2Ratsuperoxide dismutase activity enablesISOSOD2 (Homo sapiens)1624291 PMID:12551919 more ...RGDPMID:12551919 more ...
Sod2Ratsuperoxide dismutase activity enablesISSUniProtKB:P041791600115GO_REF:0000024UniProtGO_REF:0000024
Sod2Ratsuperoxide dismutase activity  IDA 2291939 RGD 
Sod2Ratsuperoxide dismutase activity  IDA 1582451 RGD 
1 to 20 of 20 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2Rathypertension pathway  IDA 1580833 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod2RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016

1 to 20 of 157 rows
#
Reference Title
Reference Citation
1. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Agharazii M, etal., Am J Hypertens. 2015 Jun;28(6):746-55. doi: 10.1093/ajh/hpu225. Epub 2014 Nov 27.
2. Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia. Alachkar H, etal., Pharmacogenomics J. 2016 Mar 29. doi: 10.1038/tpj.2016.7.
3. Effects of static magnetic field exposure on antioxidative enzymes activity and DNA in rat brain. Amara S, etal., Gen Physiol Biophys. 2009 Sep;28(3):260-5.
4. Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Andreassen OA, etal., Exp Neurol. 2001 Jan;167(1):189-95. doi: 10.1006/exnr.2000.7525.
5. Hydrogen peroxide affects contractile activity and anti-oxidant enzymes in rat uterus. Appiah I, etal., Br J Pharmacol. 2009 Dec;158(8):1932-41. Epub .
6. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
7. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Archer SL, etal., Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.
8. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
9. Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. Assem M, etal., Am J Pathol. 1997 Aug;151(2):549-55.
10. Nutrition- and virus-induced stress represses the expression of manganese superoxide dismutase in vitro. Berger MM, etal., Exp Biol Med (Maywood). 2004 Sep;229(8):843-9.
11. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. Bergman M, etal., J Cancer Res Clin Oncol. 2005 Jul;131(7):439-44. Epub 2005 May 10.
12. Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung. Biaggio VS, etal., Exp Lung Res. 2010 Feb;36(1):31-44.
13. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Bonder CS, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G676-84. Epub 2004 Apr 15.
14. Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. Botre C, etal., Cell Mol Biol Lett. 2015 Dec;20(4):685-97. doi: 10.1515/cmble-2015-0041.
15. Rat mitochondrial manganese superoxide dismutase: amino acid positions involved in covalent modifications, activity, and heat stability. Castellano I, etal., Biopolymers. 2009 Dec;91(12):1215-26.
16. Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. Celojevic D, etal., Ophthalmic Genet. 2013 May 2.
17. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
18. Gene expression changes after hypoxic preconditioning in rat hepatocytes. Chen W, etal., Hepatobiliary Pancreat Dis Int. 2006 Aug;5(3):416-21.
19. Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. Cherry AD, etal., J Biol Chem. 2014 Jan 3;289(1):41-52. doi: 10.1074/jbc.M113.512483. Epub 2013 Nov 19.
20. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Comhair SA, etal., Am J Pathol. 2005 Mar;166(3):663-74.
1 to 20 of 157 rows
PMID:7333654   PMID:7493016   PMID:9393747   PMID:9462746   PMID:9651187   PMID:9927656   PMID:10049502   PMID:11156968   PMID:11226230   PMID:11527927   PMID:11583975   PMID:11796207  
PMID:12176043   PMID:12551919   PMID:12646716   PMID:12709579   PMID:12769190   PMID:12865426   PMID:12931191   PMID:14651853   PMID:14980699   PMID:15182862   PMID:15205258   PMID:15375579  
PMID:15489334   PMID:15637112   PMID:15642323   PMID:15781740   PMID:16103131   PMID:16219542   PMID:16238459   PMID:16677818   PMID:16843623   PMID:16873728   PMID:17023425   PMID:17023572  
PMID:17145560   PMID:17215005   PMID:17322295   PMID:17349848   PMID:17367743   PMID:17597094   PMID:17634366   PMID:17670746   PMID:17923681   PMID:18218638   PMID:18559338   PMID:18614015  
PMID:19047792   PMID:19265433   PMID:19376215   PMID:19478076   PMID:19500508   PMID:19774674   PMID:19822147   PMID:19893080   PMID:20235222   PMID:20489163   PMID:20495008   PMID:20654064  
PMID:21143912   PMID:21357467   PMID:21506880   PMID:21625958   PMID:21942371   PMID:21988832   PMID:22043833   PMID:22171425   PMID:22474353   PMID:22540739   PMID:22732938   PMID:22758933  
PMID:22829583   PMID:22981416   PMID:23157833   PMID:23168492   PMID:23195678   PMID:23238024   PMID:23275324   PMID:23376485   PMID:23533145   PMID:23935993   PMID:24191052   PMID:24465521  
PMID:24527463   PMID:24563852   PMID:25978844   PMID:26071777   PMID:26231211   PMID:26316108   PMID:26721595   PMID:26770652   PMID:27021683   PMID:27067422   PMID:29116107   PMID:29775122  
PMID:29847079   PMID:30502252   PMID:30811038   PMID:33099744   PMID:34169429   PMID:34670409   PMID:36153454   PMID:36922709   PMID:37921754   PMID:38659023  



Sod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,043,323 - 50,050,168 (-)NCBIGRCr8
mRatBN7.2147,638,318 - 47,645,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,187,171 - 48,194,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,175,067 - 54,181,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,262,686 - 48,269,531 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,914,757 - 47,921,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,827,380 - 51,834,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,862,997 - 41,870,327 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,865,943 - 41,873,272 (-)NCBI
Celera143,323,111 - 43,329,909 (-)NCBICelera
Cytogenetic Map1q11NCBI
SOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,669,069 - 159,762,281 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,669,069 - 159,762,529 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,090,101 - 160,183,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,020,138 - 160,034,343 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,073,582 - 160,084,614NCBI
Celera6160,747,601 - 160,761,803 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,570,584 - 157,584,704 (-)NCBIHuRef
CHM1_16160,363,031 - 160,377,215 (-)NCBICHM1_1
T2T-CHM13v2.06160,914,924 - 161,007,912 (-)NCBIT2T-CHM13v2.0
Sod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,226,726 - 13,237,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,225,733 - 13,258,950 (+)EnsemblGRCm39 Ensembl
GRCm381713,007,839 - 13,018,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1713,006,846 - 13,040,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,200,705 - 13,210,985 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,850,771 - 12,861,051 (+)NCBIMGSCv36mm8
Celera1713,040,822 - 13,051,101 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.75NCBI
Sod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,209,101 - 21,224,163 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,209,101 - 21,223,538 (+)NCBIChiLan1.0ChiLan1.0
SOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,778,227 - 179,792,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,683,324 - 177,697,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,562,814 - 157,610,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,576,082 - 162,589,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,576,082 - 162,589,960 (-)Ensemblpanpan1.1panPan2
SOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,943,472 - 48,955,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,836,262 - 48,955,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,785,674 - 49,797,617 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,127,570 - 49,139,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,020,475 - 49,139,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,010,294 - 49,022,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,881,250 - 48,893,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,447,616 - 49,459,607 (-)NCBIUU_Cfam_GSD_1.0
Sod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,926,345 - 143,939,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,178,015 - 11,191,781 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,178,338 - 11,191,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,679,352 - 7,689,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,679,352 - 7,689,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,475,310 - 9,485,526 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,284,537 - 87,297,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,280,686 - 87,297,974 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,683,827 - 59,727,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,260,809 - 3,271,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,260,800 - 3,271,864 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sod2
59 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Western blot//MicroarrayFunctional MTI19142192

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:127
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000025794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

1 to 10 of 45 rows
RH130474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,639,557 - 47,639,751 (+)MAPPERmRatBN7.2
Rnor_6.0147,915,997 - 47,916,190NCBIRnor6.0
Rnor_5.0151,832,799 - 51,832,992UniSTSRnor5.0
RGSC_v3.4141,864,237 - 41,864,430UniSTSRGSC3.4
Celera143,324,351 - 43,324,544UniSTS
Cytogenetic Map1q21UniSTS
RH94608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,643,876 - 47,644,042 (+)MAPPERmRatBN7.2
Rnor_6.0147,920,301 - 47,920,466NCBIRnor6.0
Rnor_5.0151,828,501 - 51,828,666UniSTSRnor5.0
RGSC_v3.4141,869,041 - 41,869,206UniSTSRGSC3.4
Celera143,328,623 - 43,328,788UniSTS
Cytogenetic Map1q21UniSTS
RH140146  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8150,043,187 - 50,043,380 (+)Marker Load Pipeline
mRatBN7.2147,638,182 - 47,638,375 (+)MAPPERmRatBN7.2
Rnor_6.0147,914,622 - 47,914,814NCBIRnor6.0
Rnor_5.0151,834,175 - 51,834,367UniSTSRnor5.0
RGSC_v3.4141,862,862 - 41,863,054UniSTSRGSC3.4
Celera143,322,976 - 43,323,168UniSTS
Cytogenetic Map1q21UniSTS
RH140197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,638,964 - 47,639,163 (+)MAPPERmRatBN7.2
Rnor_6.0147,915,404 - 47,915,602NCBIRnor6.0
Rnor_5.0151,833,387 - 51,833,585UniSTSRnor5.0
RGSC_v3.4141,863,644 - 41,863,842UniSTSRGSC3.4
Celera143,323,758 - 43,323,956UniSTS
RH 3.4 Map1537.1UniSTS
Cytogenetic Map1q21UniSTS
Sod2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2566,258,521 - 66,258,762 (-)MAPPERmRatBN7.2
Rnor_6.0565,611,977 - 65,612,217NCBIRnor6.0
Rnor_5.0570,095,646 - 70,095,886UniSTSRnor5.0
RGSC_v3.4568,929,154 - 68,929,394UniSTSRGSC3.4
Celera561,395,425 - 61,395,665UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map1q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000025794   ⟹   ENSRNOP00000025794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,636,528 - 47,645,189 (-)Ensembl
Rnor_6.0 Ensembl147,914,759 - 47,921,587 (-)Ensembl
RefSeq Acc Id: NM_017051   ⟹   NP_058747
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,043,323 - 50,050,168 (-)NCBI
mRatBN7.2147,638,318 - 47,645,163 (-)NCBI
Rnor_6.0147,914,757 - 47,921,587 (-)NCBI
Rnor_5.0151,827,380 - 51,834,232 (+)NCBI
RGSC_v3.4141,862,997 - 41,870,327 (-)RGD
Celera143,323,111 - 43,329,909 (-)RGD
Sequence:
Protein RefSeqs NP_058747 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH70913 (Get FASTA)   NCBI Sequence Viewer  
  ACV32533 (Get FASTA)   NCBI Sequence Viewer  
  CAA39937 (Get FASTA)   NCBI Sequence Viewer  
  CAA68549 (Get FASTA)   NCBI Sequence Viewer  
  EDL83700 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025794.3
GenBank Protein P07895 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058747   ⟸   NM_017051
- Peptide Label: precursor
- UniProtKB: P07895 (UniProtKB/Swiss-Prot),   A6KP26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025794   ⟸   ENSRNOT00000025794
Name Modeler Protein Id AA Range Protein Structure
AF-P07895-F1-model_v2 AlphaFold P07895 1-222 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689611
Promoter ID:EPDNEW_R135
Type:multiple initiation site
Name:Sod2_1
Description:superoxide dismutase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,921,573 - 47,921,633EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-61596 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000019048 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025794.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.990 UniProtKB/Swiss-Prot
  3.55.40.20 UniProtKB/Swiss-Prot
  Fe,Mn superoxide dismutase (SOD) domain UniProtKB/TrEMBL
  Iron/manganese superoxide dismutase, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104698 IMAGE-MGC_LOAD
InterPro Fe/Mn_Superoxide_Dismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mn/Fe_SOD_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91729 IMAGE-MGC_LOAD
NCBI Gene 24787 ENTREZGENE
PANTHER SUPEROXIDE DISMUTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Fe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sod_Fe_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SOD2 RGD
PhenoGen Sod2 PhenoGen
PIRSF SODismutase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MNSODISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_MN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019048 RatGTEx
Superfamily-SCOP Fe,Mn superoxide dismutase (SOD), C-terminal domain UniProtKB/TrEMBL
  Fe,Mn superoxide dismutase (SOD), N-terminal domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF54719 UniProtKB/Swiss-Prot
UniProt A6KP26 ENTREZGENE, UniProtKB/TrEMBL
  P07895 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod2  superoxide dismutase 2  Sod2  superoxide dismutase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sod2  superoxide dismutase 2, mitochondrial    superoxide dismutase 2  Name updated 1299863 APPROVED
2003-04-09 Sod2  superoxide dismutase 2    Superoxide dismutase 2, mitochondrial  Name updated 629478 APPROVED
2001-12-21 Sod2  Superoxide dismutase 2, mitochondrial      Name updated 69729 APPROVED

Note Type Note Reference
gene_cellular_localization localized to mitochondria 628320
gene_function dismutates reactive oxygen radical species (ROS) to hydrogen peroxide and molecular oxygen 628320
gene_process prevents accumulation of superoxides in cells 628320
gene_regulation caloric restriction (CR) significantly increased mRNA (>287%) level 628320
gene_transcript contains at least 5 exons 729952