RGD Reference Report - Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus. - Rat Genome Database

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Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus.

Authors: Wang, SJ  Zhao, XH  Chen, W  Bo, N  Wang, XJ  Chi, ZF  Wu, W 
Citation: Wang SJ, etal., Mol Med Rep. 2015 Jan;11(1):521-6. doi: 10.3892/mmr.2014.2724. Epub 2014 Oct 21.
RGD ID: 11035304
Pubmed: PMID:25333348   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2014.2724   (Journal Full-text)

Sirtuin 1 (SIRT1) regulates numerous neuronal processes, including metabolism, antioxidation and aging, through activation of peroxisome proliferator-activated receptor coactivator 1-alpha (PGC-1alpha), an upstream regulator of mitochondrial biogenesis and function. However, the role of SIRT1 in the oxidative stress induced by seizures has yet to be elucidated. The present study aimed to investigate whether SIRT1 was involved in the activation of the PGC-1alpha/mitochondrial antioxidant system following status epilepticus (SE) in rats. The data demonstrated that SIRT1 expression and activity were enhanced in the rat hippocampus following SE. SIRT1 inhibition effectively blocked the SE-associated increase in PGC-1alpha and mitochondrial antioxidant enzymes, including superoxide dismutase 2 (SOD2) and uncoupling protein 2 (UCP2). Additionally, it was also demonstrated that the activation of SIRT1 enhanced mitochondrial electron transport chain complex I activity and increased ATP content. In conclusion, the present results suggest that SIRT1 activation may alleviate mitochondrial oxidative stress induced by seizures partially via PGC-1alpha signaling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
status epilepticus  ISOSod2 (Rattus norvegicus)11035304; 11035304mRNA and protein:increased expression:hippocampusRGD 
status epilepticus  IEP 11035304mRNA and protein:increased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Sod2  (superoxide dismutase 2)

Genes (Mus musculus)
Sod2  (superoxide dismutase 2, mitochondrial)

Genes (Homo sapiens)
SOD2  (superoxide dismutase 2)


Additional Information