Drd3 (dopamine receptor D3) - Rat Genome Database

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Gene: Drd3 (dopamine receptor D3) Chinchilla lanigera
Analyze
Symbol: Drd3
Name: dopamine receptor D3
RGD ID: 9065089
Description: ENCODES a protein that exhibits D1 dopamine receptor binding (ortholog); dopamine neurotransmitter receptor activity, coupled via Gi/Go (ortholog); protein domain specific binding (ortholog); INVOLVED IN acid secretion (ortholog); adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH Alzheimer's disease (ortholog); amnestic disorder (ortholog); amphetamine abuse (ortholog); FOUND IN apical part of cell (ortholog); cell projection (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D(3) dopamine receptor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (ISO)
arachidonic acid secretion  (ISO)
autophagy  (ISO)
behavioral response to cocaine  (ISO)
circadian regulation of gene expression  (ISO)
dopamine receptor signaling pathway  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
intracellular calcium ion homeostasis  (ISO)
locomotory behavior  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of dopamine receptor signaling pathway  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of sodium:proton antiporter activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of dopamine receptor signaling pathway  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
regulation of blood volume by renin-angiotensin  (ISO)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of dopamine secretion  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
response to amphetamine  (ISO)
response to cocaine  (ISO)
response to ethanol  (ISO)
response to histamine  (ISO)
response to morphine  (ISO)
response to xenobiotic stimulus  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Drd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBIChiLan1.0ChiLan1.0
DRD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383114,127,580 - 114,199,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3114,127,580 - 114,199,407 (-)EnsemblGRCh38hg38GRCh38
GRCh373113,846,427 - 113,918,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363115,330,247 - 115,380,589 (-)NCBINCBI36Build 36hg18NCBI36
Celera3112,255,976 - 112,306,017 (-)NCBICelera
Cytogenetic Map3q13.31NCBI
HuRef3111,221,547 - 111,271,509 (-)NCBIHuRef
CHM1_13113,810,902 - 113,860,923 (-)NCBICHM1_1
T2T-CHM13v2.03116,848,840 - 116,920,342 (-)NCBIT2T-CHM13v2.0
Drd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,574,285 - 43,646,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1643,574,389 - 43,643,295 (+)EnsemblGRCm39 Ensembl
GRCm381643,754,015 - 43,825,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1643,754,026 - 43,822,932 (+)EnsemblGRCm38mm10GRCm38
MGSCv371643,762,355 - 43,822,952 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361643,681,574 - 43,742,171 (+)NCBIMGSCv36mm8
Celera1644,116,581 - 44,178,828 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1628.44NCBI
Drd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81170,385,586 - 70,437,793 (-)NCBIGRCr8
mRatBN7.21156,879,689 - 56,931,901 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,879,689 - 56,940,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1165,692,856 - 65,745,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,355,096 - 58,407,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01157,403,823 - 57,463,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01161,819,102 - 61,883,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,822,077 - 61,874,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,955,136 - 61,016,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,446,901 - 58,520,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,504,489 - 58,578,178 (-)NCBI
Celera1156,432,639 - 56,484,538 (-)NCBICelera
Cytogenetic Map11q21NCBI
DRD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22112,119,170 - 112,171,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13112,123,944 - 112,175,818 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03111,265,834 - 111,317,176 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13118,187,636 - 118,237,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3118,187,636 - 118,237,403 (-)Ensemblpanpan1.1panPan2
DRD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13318,369,362 - 18,414,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3318,372,865 - 18,412,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3318,479,435 - 18,522,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03318,617,139 - 18,660,020 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3318,616,976 - 18,660,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13318,420,282 - 18,463,050 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03318,472,599 - 18,515,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03319,017,562 - 19,060,421 (-)NCBIUU_Cfam_GSD_1.0
Drd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602135,897,271 - 135,945,568 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365361,580,732 - 1,616,725 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365361,580,732 - 1,616,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13145,771,774 - 145,819,168 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113145,769,294 - 145,817,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,329,068 - 155,375,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12266,683,987 - 66,737,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2266,691,177 - 66,736,690 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604199,729,580 - 99,781,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473134,319,130 - 34,363,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473134,318,733 - 34,369,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021256   ⟹   ENSCLAP00000021055
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542714,219,594 - 14,252,178 (-)Ensembl
RefSeq Acc Id: XM_013515044   ⟹   XP_013370498
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515045   ⟹   XP_013370499
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542714,219,519 - 14,252,178 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370498 (Get FASTA)   NCBI Sequence Viewer  
  XP_013370499 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021055
  ENSCLAP00000021055.1
Reference Protein Sequences
RefSeq Acc Id: XP_013370499   ⟸   XM_013515045
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VV60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370498   ⟸   XM_013515044
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VV60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021055   ⟸   ENSCLAT00000021256
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014423 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021256 ENTREZGENE
  ENSCLAT00000021256.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Dopamine_D3_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Drd3 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  D(3) DOPAMINE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED3R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C2VV60 ENTREZGENE, UniProtKB/TrEMBL