RGD Reference Report - Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease. - Rat Genome Database

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Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease.

Authors: Nagai, Y  Ueno, S  Saeki, Y  Soga, F  Hirano, M  Yanagihara, T 
Citation: Nagai Y, etal., Neurology. 1996 Mar;46(3):791-5.
RGD ID: 5686419
Pubmed: PMID:8618685   (View Abstract at PubMed)

We investigated the dopamine receptor (DAR) mRNA expression in peripheral blood lymphocytes from 45 patients with Parkinson's disease (PD) and 21 age-matched controls using the quantitative reverse transcription and polymerase chain reaction method. Beta-actin mRNA was used as an internal control to evaluate the relative expression level of the DAR mRNA. There was a statistically significant decrease of the D3 dopamine receptor (D3R) mRNA expression in PD patients compared with that in controls. There was no change in expression of the D5 dopamine reception mRNA in PD patients. A further binding study showed reduction of the D3R binding sites in PD lymphocytes. The decrease of the D3R mRNA expression correlated with the degree of clinical severity in PD patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinson's disease severityIEP 5686419mRNA:decreased expression:blood and lymphocyteRGD 
Parkinson's disease severityISODRD3 (Homo sapiens)5686419; 5686419mRNA:decreased expression:blood and lymphocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd3  (dopamine receptor D3)

Genes (Mus musculus)
Drd3  (dopamine receptor D3)

Genes (Homo sapiens)
DRD3  (dopamine receptor D3)


Additional Information