MBLAC1 (metallo-beta-lactamase domain containing 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MBLAC1 (metallo-beta-lactamase domain containing 1) Canis lupus familiaris
Analyze
Symbol: MBLAC1
Name: metallo-beta-lactamase domain containing 1
RGD ID: 40916246
Description: ENCODES a protein that exhibits metal ion binding (inferred); RNA endonuclease activity (inferred); INVOLVED IN histone mRNA metabolic process (inferred); mRNA 3'-end processing (inferred); positive regulation of G1/S transition of mitotic cell cycle (inferred); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metallo-beta-lactamase domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,473,599 - 9,475,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,410,568 - 9,412,132 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,409,550 - 9,416,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,259,889 - 9,261,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,240,209 - 9,241,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,419,790 - 9,421,354 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
MBLAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,473,599 - 9,475,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,410,568 - 9,412,132 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,409,550 - 9,416,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,259,889 - 9,261,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,240,209 - 9,241,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,419,790 - 9,421,354 (-)NCBIUU_Cfam_GSD_1.0
MBLAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,126,967 - 100,128,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,126,785 - 100,128,495 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,724,590 - 99,726,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,562,253 - 99,564,057 (+)NCBINCBI36Build 36hg18NCBI36
Celera794,459,580 - 94,461,384 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,359,423 - 94,361,227 (+)NCBIHuRef
CHM1_1799,654,463 - 99,656,267 (+)NCBICHM1_1
T2T-CHM13v2.07101,366,818 - 101,368,346 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,084,436 - 99,086,240 (+)NCBI
Mblac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,192,576 - 138,193,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,192,576 - 138,193,883 (+)EnsemblGRCm39 Ensembl
GRCm385138,194,314 - 138,195,621 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,194,314 - 138,195,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,635,542 - 138,636,628 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,424,102 - 138,425,188 (+)NCBIMGSCv36mm8
Celera5135,173,822 - 135,174,908 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.98NCBI
Mblac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,185,142 - 22,186,404 (+)NCBIGRCr8
mRatBN7.21217,071,465 - 17,072,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,071,465 - 17,072,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,894,823 - 17,896,085 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,518,568 - 18,519,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,571,974 - 17,573,236 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,335,841 - 19,337,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,335,841 - 19,337,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,393,471 - 21,394,733 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,636,473 - 17,637,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,625,994 - 17,627,256 (+)NCBI
Celera1219,001,603 - 19,002,865 (+)NCBICelera
Cytogenetic Map12q11NCBI
Mblac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573745,202 - 747,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573745,202 - 747,402 (-)NCBIChiLan1.0ChiLan1.0
MBLAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,045,877 - 118,047,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,310,931 - 166,312,516 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,162,025 - 92,163,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,595,134 - 105,596,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,595,781 - 105,596,582 (+)Ensemblpanpan1.1panPan2
Mblac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,773,460 - 133,774,737 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543262,033 - 262,848 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543261,294 - 263,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBLAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,031,835 - 8,033,484 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,029,776 - 8,033,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MBLAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,950,091 - 12,951,859 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,950,389 - 12,951,189 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,321,031 - 3,322,822 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mblac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,870,789 - 16,871,574 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,870,490 - 16,871,646 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MBLAC1
27 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023124   ⟹   ENSCAFP00000048435
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078172   ⟹   ENSCAFP00000054029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl69,473,423 - 9,474,613 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004507   ⟹   ENSCAFP00845003603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl69,409,550 - 9,416,597 (-)Ensembl
RefSeq Acc Id: XM_038478051   ⟹   XP_038333979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,259,889 - 9,261,451 (-)NCBI
RefSeq Acc Id: XM_038478052   ⟹   XP_038333980
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,259,889 - 9,261,451 (-)NCBI
RefSeq Acc Id: XM_038539338   ⟹   XP_038395266
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,419,790 - 9,421,354 (-)NCBI
RefSeq Acc Id: XM_038539339   ⟹   XP_038395267
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,419,790 - 9,421,354 (-)NCBI
RefSeq Acc Id: XM_038603430   ⟹   XP_038459358
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,240,209 - 9,241,773 (-)NCBI
RefSeq Acc Id: XM_038603431   ⟹   XP_038459359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,240,209 - 9,241,773 (-)NCBI
RefSeq Acc Id: XM_038668119   ⟹   XP_038524047
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,410,568 - 9,412,132 (-)NCBI
RefSeq Acc Id: XM_038668120   ⟹   XP_038524048
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,410,568 - 9,412,132 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000054029   ⟸   ENSCAFT00000078172
RefSeq Acc Id: ENSCAFP00000048435   ⟸   ENSCAFT00000023124
RefSeq Acc Id: XP_038333980   ⟸   XM_038478052
RefSeq Acc Id: XP_038333979   ⟸   XM_038478051
RefSeq Acc Id: XP_038459359   ⟸   XM_038603431
RefSeq Acc Id: XP_038459358   ⟸   XM_038603430
RefSeq Acc Id: XP_038524048   ⟸   XM_038668120
- UniProtKB: A0A8C0NV75 (UniProtKB/TrEMBL),   A0A8I3MLW7 (UniProtKB/TrEMBL),   A0A8C0STW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524047   ⟸   XM_038668119
- UniProtKB: A0A8C0NV75 (UniProtKB/TrEMBL),   A0A8I3MLW7 (UniProtKB/TrEMBL),   A0A8C0STW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395267   ⟸   XM_038539339
- UniProtKB: A0A8C0NV75 (UniProtKB/TrEMBL),   A0A8C0STW3 (UniProtKB/TrEMBL),   A0A8I3MLW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395266   ⟸   XM_038539338
- UniProtKB: A0A8C0NV75 (UniProtKB/TrEMBL),   A0A8C0STW3 (UniProtKB/TrEMBL),   A0A8I3MLW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003603   ⟸   ENSCAFT00845004507
Protein Domains
Metallo-beta-lactamase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014568 Ensembl
  ENSCAFG00030018745 UniProtKB/TrEMBL
  ENSCAFG00040016676 UniProtKB/TrEMBL
  ENSCAFG00845002546 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030034482.1 UniProtKB/TrEMBL
  ENSCAFT00040030790.1 UniProtKB/TrEMBL
  ENSCAFT00845004507 ENTREZGENE
  ENSCAFT00845004507.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.15.10 UniProtKB/TrEMBL
InterPro MBLAC1 UniProtKB/TrEMBL
  Metallo-B-lactamas UniProtKB/TrEMBL
  RibonucZ/Hydroxyglut_hydro UniProtKB/TrEMBL
NCBI Gene MBLAC1 ENTREZGENE
PANTHER METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR23200 UniProtKB/TrEMBL
Pfam Lactamase_B UniProtKB/TrEMBL
SMART Lactamase_B UniProtKB/TrEMBL
Superfamily-SCOP SSF56281 UniProtKB/TrEMBL
UniProt A0A8C0NV75 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0STW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MLW7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 MBLAC1  metallo-beta-lactamase domain containing 1  MBLAC1  metallo-beta-lactamase domain containing 1  Data merged from RGD:12175397 737654 PROVISIONAL