MBLAC1 (metallo-beta-lactamase domain containing 1)

Gene: MBLAC1 (metallo-beta-lactamase domain containing 1) Chlorocebus sabaeus

Analyze

Symbol:

MBLAC1

Name:

metallo-beta-lactamase domain containing 1

RGD ID:

18701888

Description:

ENCODES a protein that exhibits metal ion binding (ortholog); RNA endonuclease activity (ortholog); INVOLVED IN histone mRNA metabolic process (ortholog); mRNA 3'-end processing (ortholog); positive regulation of G1/S transition of mitotic cell cycle (ortholog); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

metallo-beta-lactamase domain-containing protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,950,091 - 12,951,859 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,950,389 - 12,951,189 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,321,031 - 3,322,822 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

histone mRNA metabolic process (ISO)

mRNA 3'-end processing (ISO)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA)

nucleus (ISO)

Molecular Function

metal ion binding (ISO)

RNA endonuclease activity (ISO)

References

Genomics

Comparative Map Data

MBLAC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,950,091 - 12,951,859 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,950,389 - 12,951,189 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,321,031 - 3,322,822 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MBLAC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,126,967 - 100,128,495 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,126,785 - 100,128,495 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	99,724,590 - 99,726,118 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,562,253 - 99,564,057 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	94,459,580 - 94,461,384 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,359,423 - 94,361,227 (+)	NCBI		HuRef
CHM1_1	7	99,654,463 - 99,656,267 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,366,818 - 101,368,346 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,084,436 - 99,086,240 (+)	NCBI

Mblac1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,192,576 - 138,193,883 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	138,192,576 - 138,193,883 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	138,194,314 - 138,195,621 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,194,314 - 138,195,621 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	138,635,542 - 138,636,628 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,424,102 - 138,425,188 (+)	NCBI		MGSCv36	mm8
Celera	5	135,173,822 - 135,174,908 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.98	NCBI

Mblac1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	22,185,142 - 22,186,404 (+)	NCBI		GRCr8
mRatBN7.2	12	17,071,465 - 17,072,736 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	17,071,465 - 17,072,735 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,894,823 - 17,896,085 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,518,568 - 18,519,830 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,571,974 - 17,573,236 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,335,841 - 19,337,103 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,335,841 - 19,337,102 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	21,393,471 - 21,394,733 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	17,636,473 - 17,637,735 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	17,625,994 - 17,627,256 (+)	NCBI
Celera	12	19,001,603 - 19,002,865 (+)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Mblac1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	745,202 - 747,402 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955573	745,202 - 747,402 (-)	NCBI	ChiLan1.0	ChiLan1.0

MBLAC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	118,045,877 - 118,047,865 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,310,931 - 166,312,516 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	92,162,025 - 92,163,678 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,595,134 - 105,596,884 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,595,781 - 105,596,582 (+)	Ensembl	panpan1.1		panPan2

MBLAC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,473,599 - 9,475,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,473,135 - 9,474,613 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,473,135 - 9,474,613 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	6	9,410,568 - 9,412,132 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,409,550 - 9,416,597 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,259,889 - 9,261,451 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	9,240,209 - 9,241,773 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,419,790 - 9,421,354 (-)	NCBI		UU_Cfam_GSD_1.0

Mblac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,773,460 - 133,774,737 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	262,033 - 262,848 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	261,294 - 263,789 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MBLAC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,031,835 - 8,033,484 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	8,029,776 - 8,033,492 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Mblac1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,870,789 - 16,871,574 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	16,870,490 - 16,871,646 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	1		10
Low	35	20	50
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008018584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008018585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000019578 ⟹ ENSCSAP00000018992

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	28	12,950,389 - 12,951,189 (-)	Ensembl

RefSeq Acc Id:

XM_008018584 ⟹ XP_008016775

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	28	12,950,091 - 12,951,859 (-)	NCBI
Vero_WHO_p1.0	NW_023666070	3,321,031 - 3,322,822 (+)	NCBI

Sequence:

show sequence

TACTCGGGGGGCTGAGGCGGGAGGATCGCATGAGTCCAGGAGGTCGAGGCTGCAGTGAGATCTG
ATCGCGCCACTGCACTCCAGCCTGGACAACTGAGCATGACCCTTCCTCAGGGCTAATGGCGCTT
CATAATTCTGCAGTCCAAGGAAGCTTCTGGGGTCGCGGGGCGGAGAACCGCCAAGAGGCTGGAG
TGCAAAGAGCCTCCTGTGGCAGACGGTAAAGGCGCCGGAACTACAGCTACCTCCGCGACGCCGT
TTCGGCCGCCATATCTGGGTGCACGGGAACTCGCAGAGGACAAACTCCCACGCGCGTTTTCGAT
TTCTGCGCTTTCCTCGAGTGAGGCAAGACTTAGCAGAGGCCCAAGCCCGTCCCTCCCTGCCAGG
AGCAGCCTCATGCGGACCGAGCCATTGCGCGGGGCGTCCCCTCTGCTGGTGCCCGGCGACCCCT
ACTCCGTGGTGGTTCTGCTGCAGGGCTACGCGGAGCCCGAGGGGGTGGGCGACGCCGTGCGCGC
CGACGGCTCCGTAACCCTGGTCCTACCCCAGACCCGGGGCCCGGCCTCCAGCCACCGAAAGTCC
CCGCGCGGGAGTGGCGGCGCAGAGGCCGCCCTGGAGGAGGCGGCCCGTGGCCCCATCCTGGTGG
ACACCGGGGGCCCCTGGGCTCGGGAGGCGCTGCTGAGGGCGCTGGCGGGGCAGGGCGTGGCCCC
GGGAGACGTGAAGCTGGTTGTGGGAACCCATGGGCACTCAGATCACATCGGGAACTTGGGGCTG
TTCCCAGGCGCGGCTCTGCTGGTCTCGCACGACTTCTGCCTCCCCGGAGGCCGCTACCTGCCCC
ACGGGCTGGGTGAGGGGCAGCCCCTGCGCCTGGGCCCGGGGCTCGAGGTGTGGGCCACGCCGGG
CCACGGGGGCCAGCGCGACGTGAGCGTGGTGGTGGCCGGCACGGCTCTGGGTACCGTAGTGGTG
GCGGGGGATGTGTTTGAGCGAGATGGGGACGAGGATTCGTGGCAGGCGCTGAGTGAAGACCCCG
CAGCCCAGGAGCGGAGCCGGAAGAGAGTCCTGGTCGTTGCCGACGTGGTCGTACCTGGTCACGG
GCCCCCCTTTCGAGTGCTCAGGGAAGCTGCGCAGACCGAGACGGAGGGTGGAGGGAACAGCCAG
CAGGAGCCGGTGGTCGGAGACGAGGAGCCCGCCCCGCACTGATCAGCCCAGAGAGGGACCGGAC
TCTTGTAAGCCCTAACAGCCAGGAGTTGCTGGAGACAAAGTCAGAGCAGTCAAGGGTGGGAGCT
TCCAGCCCTTCCAGGAGGCTAGTTTTCCAGTGAGGACAGAGTGCACCCTGACACTGCCATCACA
TCGTCAGTATCATTGCCTATCTCTGCCACCAAACTAAGATCAAAGGACAGGCTCAGCTCCCTGT
GCATTCTCCCTGGGCCTCAGTAAAATGGGGGAAGGTTCCTGGGAGGGGTCTCCAAAATAAAAAT
GGAAACTGCATTGAAAATCA

hide sequence

RefSeq Acc Id:

XM_008018585 ⟹ XP_008016776

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	28	12,950,091 - 12,951,823 (-)	NCBI
Vero_WHO_p1.0	NW_023666070	3,321,031 - 3,322,822 (+)	NCBI

Sequence:

show sequence

CAGGAGGTCGAGGCTGCAGTGAGATCTGATCGCGCCACTGCACTCCAGCCTGGACAACTGAGCA
TGACCCTTCCTCAGGGCTAATGGCGCTTCATAATTCTGCAGTCCAAGGAAGCTTCTGGGGTCGC
GGGGCGGAGAACCGCCAAGAGGCTGGAGTGCAAAGAGCCTCCTGTGGCAGACGGTAAAGGCGCC
GGAACTACAGCTACCTCCGCGACGCCGTTTCGGCCGCCATATCTGGGTGCACGGGAACTCGCAG
AGGACAAACTCCCACGCGCGTTTTCGATTTCTGCGCTTTCCTCGAGTGAGGCAAGACTTAGCAG
AGGCCCAAGGTAGAGCGCGCCCGTCCCTCCCTGCCAGGAGCAGCCTCATGCGGACCGAGCCATT
GCGCGGGGCGTCCCCTCTGCTGGTGCCCGGCGACCCCTACTCCGTGGTGGTTCTGCTGCAGGGC
TACGCGGAGCCCGAGGGGGTGGGCGACGCCGTGCGCGCCGACGGCTCCGTAACCCTGGTCCTAC
CCCAGACCCGGGGCCCGGCCTCCAGCCACCGAAAGTCCCCGCGCGGGAGTGGCGGCGCAGAGGC
CGCCCTGGAGGAGGCGGCCCGTGGCCCCATCCTGGTGGACACCGGGGGCCCCTGGGCTCGGGAG
GCGCTGCTGAGGGCGCTGGCGGGGCAGGGCGTGGCCCCGGGAGACGTGAAGCTGGTTGTGGGAA
CCCATGGGCACTCAGATCACATCGGGAACTTGGGGCTGTTCCCAGGCGCGGCTCTGCTGGTCTC
GCACGACTTCTGCCTCCCCGGAGGCCGCTACCTGCCCCACGGGCTGGGTGAGGGGCAGCCCCTG
CGCCTGGGCCCGGGGCTCGAGGTGTGGGCCACGCCGGGCCACGGGGGCCAGCGCGACGTGAGCG
TGGTGGTGGCCGGCACGGCTCTGGGTACCGTAGTGGTGGCGGGGGATGTGTTTGAGCGAGATGG
GGACGAGGATTCGTGGCAGGCGCTGAGTGAAGACCCCGCAGCCCAGGAGCGGAGCCGGAAGAGA
GTCCTGGTCGTTGCCGACGTGGTCGTACCTGGTCACGGGCCCCCCTTTCGAGTGCTCAGGGAAG
CTGCGCAGACCGAGACGGAGGGTGGAGGGAACAGCCAGCAGGAGCCGGTGGTCGGAGACGAGGA
GCCCGCCCCGCACTGATCAGCCCAGAGAGGGACCGGACTCTTGTAAGCCCTAACAGCCAGGAGT
TGCTGGAGACAAAGTCAGAGCAGTCAAGGGTGGGAGCTTCCAGCCCTTCCAGGAGGCTAGTTTT
CCAGTGAGGACAGAGTGCACCCTGACACTGCCATCACATCGTCAGTATCATTGCCTATCTCTGC
CACCAAACTAAGATCAAAGGACAGGCTCAGCTCCCTGTGCATTCTCCCTGGGCCTCAGTAAAAT
GGGGGAAGGTTCCTGGGAGGGGTCTCCAAAATAAAAATGGAAACTGCATTGAAAATCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008016775	(Get FASTA)	NCBI Sequence Viewer
	XP_008016776	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000018992
	ENSCSAP00000018992.1

RefSeq Acc Id:	XP_008016775 ⟸ XM_008018584
- UniProtKB:	A0A0D9SDQ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008016776 ⟸ XM_008018585
- UniProtKB:	A0A0D9SDQ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000018992 ⟸ ENSCSAT00000019578

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000019488	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000019578.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.15.10	UniProtKB/TrEMBL
InterPro	MBLAC1	UniProtKB/TrEMBL
	Metallo-B-lactamas	UniProtKB/TrEMBL
	RibonucZ/Hydroxyglut_hydro	UniProtKB/TrEMBL
KEGG Report	csab:103246751	UniProtKB/TrEMBL
NCBI Gene	MBLAC1	ENTREZGENE
PANTHER	METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	PTHR23200	UniProtKB/TrEMBL
Pfam	Lactamase_B	UniProtKB/TrEMBL
SMART	Lactamase_B	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56281	UniProtKB/TrEMBL
UniProt	A0A0D9SDQ3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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