Nox1 (NADPH oxidase 1) - Rat Genome Database

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Pathways
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Gene: Nox1 (NADPH oxidase 1) Heterocephalus glaber
Analyze
Symbol: Nox1
Name: NADPH oxidase 1
RGD ID: 18920211
Description: ENCODES a protein that exhibits NAD(P)H oxidase H2O2-forming activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); cellular response to angiotensin (ortholog); cellular response to hyperoxia (ortholog); ASSOCIATED WITH aortic atherosclerosis (ortholog); aortic dissection (ortholog); autistic disorder (ortholog); FOUND IN NADPH oxidase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,736,704 - 1,755,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
cell chemotaxis  (ISO)
cell migration  (IEA)
cellular response to angiotensin  (ISO)
cellular response to hyperoxia  (IEA,ISO)
cellular response to interleukin-1  (ISO)
cellular response to mercury ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular stress response to acidic pH  (IEA)
defense response  (IEA)
extracellular matrix organization  (IEA,ISO)
glutathione metabolic process  (ISO)
hydrogen peroxide metabolic process  (IEA)
intracellular pH elevation  (IEA)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
JNK cascade  (IEA,ISO)
MAPK cascade  (IEA,ISO)
negative regulation of neuron maturation  (ISO)
oxygen metabolic process  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of inclusion body assembly  (ISO)
positive regulation of integrin biosynthetic process  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA,ISO)
response to reactive oxygen species  (ISO)
superoxide anion generation  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Nox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,736,704 - 1,755,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X100,843,324 - 100,874,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX100,843,324 - 100,874,359 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,098,313 - 100,129,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X99,984,969 - 100,015,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X99,904,969 - 99,935,343NCBI
CeleraX100,617,105 - 100,648,120 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX89,897,075 - 89,927,719 (-)NCBIHuRef
CHM1_1X99,991,243 - 100,022,267 (-)NCBICHM1_1
T2T-CHM13v2.0X99,285,862 - 99,317,015 (-)NCBIT2T-CHM13v2.0
Nox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X132,987,170 - 133,038,455 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX132,987,170 - 133,122,705 (-)EnsemblGRCm39 Ensembl
GRCm38X134,086,421 - 134,137,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,086,421 - 134,221,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X130,621,685 - 130,646,247 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,433,496 - 129,458,058 (-)NCBIMGSCv36mm8
CeleraX116,963,302 - 116,987,732 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX55.69NCBI
Nox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X101,572,338 - 101,625,571 (-)NCBIGRCr8
mRatBN7.2X97,279,058 - 97,332,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,279,056 - 97,302,236 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX98,953,200 - 98,976,388 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,462,968 - 102,486,155 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X99,966,365 - 99,989,543 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X104,909,328 - 104,932,508 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX104,909,326 - 104,932,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X104,742,161 - 104,765,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX98,325,197 - 98,348,363 (-)NCBICelera
Cytogenetic MapXq32NCBI
Nox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555036,974,239 - 6,997,618 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555036,973,965 - 7,020,182 (-)NCBIChiLan1.0ChiLan1.0
NOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,442,780 - 100,481,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X100,446,385 - 100,477,340 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,046,023 - 90,076,968 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,182,881 - 100,215,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,182,398 - 100,215,192 (-)Ensemblpanpan1.1panPan2
NOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X74,784,627 - 74,811,796 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX74,785,168 - 74,811,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,195,825 - 76,224,844 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,195,810 - 76,224,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X73,760,799 - 73,789,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,424,758 - 75,453,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,186,299 - 75,215,328 (-)NCBIUU_Cfam_GSD_1.0
Nox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,512,975 - 63,529,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365846,024,008 - 6,039,866 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365846,023,960 - 6,040,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,540,667 - 82,586,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,540,664 - 82,575,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X90,483,590 - 90,496,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,182,636 - 89,210,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX89,183,264 - 89,209,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606514,108,862 - 14,147,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000002100   ⟹   ENSHGLP00000002052
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,736,704 - 1,755,504 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000002101   ⟹   ENSHGLP00000002053
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,736,729 - 1,754,900 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000002102   ⟹   ENSHGLP00000002054
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,736,729 - 1,754,900 (+)Ensembl
RefSeq Acc Id: XM_013068428   ⟹   XP_012923882
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBI
RefSeq Acc Id: XM_021250454   ⟹   XP_021106113
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,741,921 - 1,754,932 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012923882 (Get FASTA)   NCBI Sequence Viewer  
  XP_021106113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12428 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002052
  ENSHGLP00100000983
Reference Protein Sequences
RefSeq Acc Id: XP_012923882   ⟸   XM_013068428
- Peptide Label: isoform X1
- UniProtKB: G5BT17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106113   ⟸   XM_021250454
- Peptide Label: isoform X2
- UniProtKB: G5BT17 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000002052   ⟸   ENSHGLT00000002100
RefSeq Acc Id: ENSHGLP00000002054   ⟸   ENSHGLT00000002102
RefSeq Acc Id: ENSHGLP00000002053   ⟸   ENSHGLT00000002101


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001560 Ensembl, ENTREZGENE
  ENSHGLG00100000796 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000002100 ENTREZGENE
  ENSHGLT00100001016 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.80 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro Cyt_b245_heavy_chain UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
KEGG Report hgl:101718925 UniProtKB/TrEMBL
NCBI Gene Nox1 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/TrEMBL
  PTHR11972:SF71 UniProtKB/TrEMBL
Pfam FAD_binding_8 UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/TrEMBL
PRINTS GP91PHOX UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/TrEMBL
Superfamily-SCOP SSF52343 UniProtKB/TrEMBL
  SSF63380 UniProtKB/TrEMBL
UniProt G5BT17 ENTREZGENE, UniProtKB/TrEMBL