RGD Reference Report - Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma. - Rat Genome Database

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Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.

Authors: Kohsari, Maryam  Khadem Ansari, Mohammad Hassan  Rasmi, Yousef 
Citation: Kohsari M, etal., Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2237-2242. doi: 10.31557/APJCP.2020.21.8.2237.
RGD ID: 329955356
Pubmed: PMID:32856850   (View Abstract at PubMed)
PMCID: PMC7771943   (View Article at PubMed Central)
DOI: DOI:10.31557/APJCP.2020.21.8.2237   (Journal Full-text)


OBJECTIVE: The etiology of multiple myeloma (MM) is not known. Enzymes such as xanthine oxidase (XO) and NADPH oxidase 1 (NOX1) as relevant sources of reactive oxygen species (ROS) production may play a crucial role in the incidence and progress of MM. Uric acid generated by XO has a controversial dual role in both the prevention and promotion of cancer. We conducted a case-control study and selected patients with stage I MM to investigate the status of XO, NOX1, and uric acid in the patients and controls.
METHODS: We used a sample of 33 patients with stage I MM and 30 healthy controls. The enzyme-linked immunosorbent assay (ELISA) measured the enzyme concentration of XO and NOX1, and the colorimetric method measured the serum level of uric acid.
RESULTS: Mean serum levels for XO in patients and controls were 6.17±0.83 ng/ml and 4.12±0.57 ng/ml (P<0.001). serum levels of NOX1 were 4.35±1.03 ng/ml in patients and 3.54±0.91 ng/ml in controls (P<0.001). Evaluating the levels of XO and NOX1 in male and female populations showed a significant difference in the male population (NOX1 P=0.002; XO P<0.001) and female population (NOX1 P=0.002; XO P<0.001). Also, a significant correlation was observed between the two enzymes only in the female population (Pearson correlation=0.5; P=0.006). A significant inverse correlation found between albumin and XO (Pearson correlation=-0.7, P<0.001) and NOX1 (Pearson correlation=-0.5, P<0.001). XO was correlated with B2-m (Pearson correlation=0.37, P=0.003). There was no significant difference in uric acid between patients (6.2±1.2 mg/dl) and controls (5.7±1 mg/dl) (P=0.2), and no correlation was found with XO.
CONCLUSION: The present study indicates the possible role of XO and NOX 1 in the etiology of MM. Although we found no correlation between uric acid and XO, further studies will help clarify the function of uric acid in the pathogenesis of MM.
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RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple myeloma  IEP 329955356; 329955356; 329955356protein:increased expression:serumRGD 
multiple myeloma  ISOB2M (Homo sapiens)329955356; 329955356protein:increased expression:serumRGD 
multiple myeloma  ISONOX1 (Homo sapiens)329955356; 329955356protein:increased expression:serumRGD 
multiple myeloma  ISOXDH (Homo sapiens)329955356; 329955356protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
B2m  (beta-2 microglobulin)
Nox1  (NADPH oxidase 1)
Xdh  (xanthine dehydrogenase)

Genes (Mus musculus)
B2m  (beta-2 microglobulin)
Nox1  (NADPH oxidase 1)
Xdh  (xanthine dehydrogenase)

Genes (Homo sapiens)
B2M  (beta-2-microglobulin)
NOX1  (NADPH oxidase 1)
XDH  (xanthine dehydrogenase)


Additional Information