EGLN1 (egl-9 family hypoxia inducible factor 1) - Rat Genome Database

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Gene: EGLN1 (egl-9 family hypoxia inducible factor 1) Chlorocebus sabaeus
Analyze
Symbol: EGLN1
Name: egl-9 family hypoxia inducible factor 1
RGD ID: 18431252
Description: ENCODES a protein that exhibits enzyme binding (ortholog); peptidyl-proline dioxygenase activity (ortholog); INVOLVED IN cardiac muscle tissue morphogenesis (ortholog); heart trabecula formation (ortholog); labyrinthine layer development (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Actin-Accumulation Myopathy (ortholog); acute kidney failure (ortholog); atherosclerosis (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: egl nine homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,624,754 - 68,685,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,625,260 - 68,682,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,533,202 - 70,596,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EGLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,624,754 - 68,685,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,625,260 - 68,682,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,533,202 - 70,596,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EGLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,363,756 - 231,422,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,363,751 - 231,422,287 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,499,502 - 231,558,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,568,054 - 229,627,413 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,808,165 - 227,867,525NCBI
Celera1204,764,347 - 204,825,640 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,982,787 - 202,043,989 (-)NCBIHuRef
CHM1_11232,773,121 - 232,834,670 (-)NCBICHM1_1
T2T-CHM13v2.01230,746,985 - 230,805,510 (-)NCBIT2T-CHM13v2.0
Egln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,635,325 - 125,676,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,635,326 - 125,676,063 (-)EnsemblGRCm39 Ensembl
GRCm388124,908,587 - 124,949,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,908,587 - 124,949,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,432,487 - 127,473,154 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,794,676 - 127,801,870 (-)NCBIMGSCv36mm8
Celera8129,217,254 - 129,257,497 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.86NCBI
Egln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,765,276 - 69,804,681 (-)NCBIGRCr8
mRatBN7.21952,867,900 - 52,907,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,869,486 - 52,907,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,652,672 - 59,692,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,503,724 - 60,543,214 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,579,139 - 62,618,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,660,194 - 57,701,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,662,278 - 57,699,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,373,433 - 68,412,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,080,670 - 55,118,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,086,125 - 55,122,813 (-)NCBI
Celera1952,235,066 - 52,273,829 (-)NCBICelera
Cytogenetic Map19q12NCBI
Egln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,407,800 - 7,454,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,407,800 - 7,454,851 (+)NCBIChiLan1.0ChiLan1.0
EGLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,780,268 - 17,840,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1117,977,718 - 18,036,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,915,541 - 206,976,656 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,939,543 - 211,997,325 (-)NCBIpanpan1.1PanPan1.1panPan2
EGLN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,053,486 - 8,110,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,053,837 - 8,109,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,045,638 - 8,103,130 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,078,966 - 8,136,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,078,996 - 8,136,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,082,361 - 8,139,616 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,204,144 - 8,261,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,432,143 - 8,489,997 (+)NCBIUU_Cfam_GSD_1.0
Egln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,178,544 - 43,220,861 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648419,343,770 - 19,386,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,113,844 - 59,168,395 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,113,527 - 59,168,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,786,901 - 63,840,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Egln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,325,135 - 18,369,504 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 17 60
Low 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008370   ⟹   ENSCSAP00000006519
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2568,625,260 - 68,682,804 (-)Ensembl
RefSeq Acc Id: XM_007989796   ⟹   XP_007987987
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12568,624,754 - 68,685,961 (-)NCBI
Vero_WHO_p1.0NW_02366605570,533,202 - 70,596,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989797   ⟹   XP_007987988
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12568,625,238 - 68,682,898 (-)NCBI
Vero_WHO_p1.0NW_02366605570,533,202 - 70,594,729 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007987987 (Get FASTA)   NCBI Sequence Viewer  
  XP_007987988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006519
  ENSCSAP00000006519.1
Reference Protein Sequences
RefSeq Acc Id: XP_007987987   ⟸   XM_007989796
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RD30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987988   ⟸   XM_007989797
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000006519   ⟸   ENSCSAT00000008370


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010297 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008370.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.2220 UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/TrEMBL
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/TrEMBL
  Znf_MYND UniProtKB/TrEMBL
NCBI Gene EGLN1 ENTREZGENE
PANTHER EGL NINE HOMOLOG 1 UniProtKB/TrEMBL
  EGL NINE HOMOLOG-RELATED UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/TrEMBL
  zf-MYND UniProtKB/TrEMBL
PROSITE FE2OG_OXY UniProtKB/TrEMBL
  ZF_MYND_1 UniProtKB/TrEMBL
  ZF_MYND_2 UniProtKB/TrEMBL
SMART P4Hc UniProtKB/TrEMBL
Superfamily-SCOP HIT/MYND zinc finger-like UniProtKB/TrEMBL
UniProt A0A0D9RD30 ENTREZGENE, UniProtKB/TrEMBL