Pou2af2 (POU domain, class 2, associating factor 2) - Rat Genome Database

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Gene: Pou2af2 (POU domain, class 2, associating factor 2) Mus musculus
Analyze
Symbol: Pou2af2
Name: POU domain, class 2, associating factor 2
RGD ID: 1616765
MGI Page MGI
Description: Predicted to enable sequence-specific DNA binding activity and transcription coactivator activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human POU2AF2 (POU class 2 homeobox associating factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810046K07Rik; hypothetical protein LOC69809; OCA-B homolog; Oca-t1; oct coactivator from tuft cells 1; POU class 2 homeobox-associating factor 2; POU domain class 2-associating factor 2; uncharacterized protein C11orf53 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,200,986 - 51,240,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,200,986 - 51,240,224 (-)EnsemblGRCm39 Ensembl
GRCm38951,289,686 - 51,328,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,289,686 - 51,328,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv37951,097,791 - 51,137,022 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,041,924 - 51,081,147 (-)NCBIMGSCv36mm8
Celera948,576,872 - 48,616,362 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cellular_component  (ND)
cytoplasm  (IEA)
nucleus  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:35576971  


Genomics

Comparative Map Data
Pou2af2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,200,986 - 51,240,224 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,200,986 - 51,240,224 (-)EnsemblGRCm39 Ensembl
GRCm38951,289,686 - 51,328,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,289,686 - 51,328,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv37951,097,791 - 51,137,022 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,041,924 - 51,081,147 (-)NCBIMGSCv36mm8
Celera948,576,872 - 48,616,362 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.05NCBI
POU2AF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,245,725 - 111,286,401 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,245,725 - 111,286,401 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,116,450 - 111,157,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,631,917 - 110,662,183 (+)NCBINCBI36Build 36hg18NCBI36
Celera11108,279,889 - 108,310,160 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,051,423 - 107,081,652 (+)NCBIHuRef
CHM1_111111,009,837 - 111,040,110 (+)NCBICHM1_1
T2T-CHM13v2.011111,255,953 - 111,296,584 (+)NCBIT2T-CHM13v2.0
Pou2af2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,504,292 - 60,544,996 (-)NCBIGRCr8
mRatBN7.2851,607,780 - 51,648,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,607,763 - 51,648,628 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0855,693,820 - 55,696,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,694,804 - 55,696,601 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,288,887 - 54,330,073 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,621,532 - 54,642,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera851,152,414 - 51,155,450 (-)NCBICelera
Cytogenetic Map8q23NCBI
Pou2af2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541213,076,854 - 13,079,095 (+)NCBIChiLan1.0ChiLan1.0
POU2AF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,999,701 - 112,030,008 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,091,755 - 113,122,077 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,125,675 - 106,165,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,981,398 - 110,011,080 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11109,971,255 - 110,011,080 (+)Ensemblpanpan1.1panPan2
POU2AF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,749,430 - 21,785,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,749,786 - 21,785,287 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,671,004 - 21,707,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,775,350 - 21,811,914 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,775,711 - 21,811,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,835,943 - 21,872,425 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,736,068 - 21,772,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,785,293 - 21,821,811 (-)NCBIUU_Cfam_GSD_1.0
Pou2af2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494793,549,146 - 93,587,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,118,236 - 3,123,305 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,118,204 - 3,123,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU2AF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,024,631 - 39,062,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,024,067 - 39,065,379 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2943,922,254 - 43,962,911 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU2AF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11102,591,385 - 102,625,441 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604323,345,939 - 23,452,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou2af2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247846,356,269 - 6,410,924 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pou2af2
1243 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:241
Interacting mature miRNAs:262
Transcripts:ENSMUST00000039959, ENSMUST00000181366
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
13515057Adip20b_madiposity 20b (mouse)94870090853791702Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
11080993Tglq7_mtriglyceride level QTL 7 (mouse)95011130051511300Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039959   ⟹   ENSMUSP00000036912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl951,200,986 - 51,240,217 (-)Ensembl
GRCm38.p6 Ensembl951,289,686 - 51,328,917 (-)Ensembl
RefSeq Acc Id: ENSMUST00000181366   ⟹   ENSMUSP00000137735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl951,200,986 - 51,224,015 (-)Ensembl
GRCm38.p6 Ensembl951,289,686 - 51,312,715 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238450   ⟹   ENSMUSP00000158857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl951,200,986 - 51,240,224 (-)Ensembl
GRCm38.p6 Ensembl951,289,686 - 51,328,924 (-)Ensembl
RefSeq Acc Id: NM_001372554   ⟹   NP_001359483
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,240,218 (-)NCBI
GRCm38951,289,686 - 51,328,918 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001372555   ⟹   NP_001359484
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,240,218 (-)NCBI
GRCm38951,289,686 - 51,328,918 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001372556   ⟹   NP_001359485
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,240,218 (-)NCBI
GRCm38951,289,686 - 51,328,918 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001372557   ⟹   NP_001359486
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,223,969 (-)NCBI
GRCm38951,289,686 - 51,312,669 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027217   ⟹   NP_081493
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,240,218 (-)NCBI
GRCm38951,289,686 - 51,328,918 (-)NCBI
MGSCv37951,097,791 - 51,137,022 (-)RGD
Celera948,576,872 - 48,616,362 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510589   ⟹   XP_006510652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39951,200,986 - 51,240,224 (-)NCBI
GRCm38951,289,686 - 51,328,924 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_081493   ⟸   NM_027217
- Peptide Label: isoform 4
- UniProtKB: Q9D8Q6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510652   ⟸   XM_006510589
- Peptide Label: isoform X1
- UniProtKB: Q9D8Q6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001359485   ⟸   NM_001372556
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001359483   ⟸   NM_001372554
- Peptide Label: isoform 1
- UniProtKB: Q9D8Q6 (UniProtKB/Swiss-Prot),   A0A5K1VW51 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001359484   ⟸   NM_001372555
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001359486   ⟸   NM_001372557
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000158857   ⟸   ENSMUST00000238450
RefSeq Acc Id: ENSMUSP00000036912   ⟸   ENSMUST00000039959
RefSeq Acc Id: ENSMUSP00000137735   ⟸   ENSMUST00000181366
Protein Domains
OCA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D8Q6-F1-model_v2 AlphaFold Q9D8Q6 1-235 view protein structure

Promoters
RGD ID:6848369
Promoter ID:MM_ACW:50534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:1810046K07RIK.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36951,120,346 - 51,120,846 (-)MPROMDB
RGD ID:8669610
Promoter ID:EPDNEW_M12826
Type:multiple initiation site
Name:1810046K07Rik_1
Description:Mus musculus RIKEN cDNA 1810046K07 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38951,328,918 - 51,328,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917059 AgrOrtholog
Ensembl Genes ENSMUSG00000036027 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000039959 ENTREZGENE
  ENSMUST00000039959.11 UniProtKB/Swiss-Prot
  ENSMUST00000181366 ENTREZGENE
  ENSMUST00000181366.3 UniProtKB/Swiss-Prot
  ENSMUST00000238450 ENTREZGENE
  ENSMUST00000238450.3 UniProtKB/Swiss-Prot
InterPro C11orf53 UniProtKB/Swiss-Prot
  OCA UniProtKB/Swiss-Prot
KEGG Report mmu:69809 UniProtKB/Swiss-Prot
MGD MGI:1917059 ENTREZGENE
NCBI Gene 69809 ENTREZGENE
PANTHER PTHR28376 UniProtKB/Swiss-Prot
  RGD1562914 UniProtKB/Swiss-Prot
Pfam DUF5566 UniProtKB/Swiss-Prot
PhenoGen Pou2af2 PhenoGen
PROSITE OCA UniProtKB/Swiss-Prot
UniProt A0A5K1VW51 ENTREZGENE
  CK053_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A5K1VW51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-16 Pou2af2  POU domain, class 2, associating factor 2  1810046K07Rik  RIKEN cDNA 1810046K07 gene  Symbol and/or name updated 27372883 PROVISIONAL