Defb48 (defensin beta 48) - Rat Genome Database

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Gene: Defb48 (defensin beta 48) Mus musculus
Analyze
Symbol: Defb48
Name: defensin beta 48
RGD ID: 1613936
MGI Page MGI
Description: Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be active in extracellular space. Orthologous to human DEFB109B (defensin beta 109B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-defensin 42; beta-defensin 48; Defb42; EG432867; putative beta-defensin 109B
RGD Orthologs
Human
Rat
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm21944  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,214,974 - 63,221,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,214,973 - 63,221,959 (-)EnsemblGRCm39 Ensembl
GRCm381462,977,524 - 62,984,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,977,524 - 62,984,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,596,361 - 63,603,347 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,931,638 - 61,938,620 (-)NCBIMGSCv36mm8
Celera1460,736,259 - 60,743,070 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16033865   PMID:16141072   PMID:16141073   PMID:16602821   PMID:20003482  
PMID:21873635  


Genomics

Comparative Map Data
Defb48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,214,974 - 63,221,959 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,214,973 - 63,221,959 (-)EnsemblGRCm39 Ensembl
GRCm381462,977,524 - 62,984,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,977,524 - 62,984,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,596,361 - 63,603,347 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,931,638 - 61,938,620 (-)NCBIMGSCv36mm8
Celera1460,736,259 - 60,743,070 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.23NCBI
DEFB109B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,309,535 - 7,320,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,312,722 - 7,320,096 (+)EnsemblGRCh38hg38GRCh38
GRCh3787,167,057 - 7,177,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,157,777 - 7,164,882 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map8p23.1NCBI
HuRef86,865,006 - 6,872,110 (+)NCBIHuRef
CHM1_187,450,324 - 7,457,428 (-)NCBICHM1_1
T2T-CHM13v2.087,038,512 - 7,049,075 (+)NCBIT2T-CHM13v2.0
Defb42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,410,651 - 41,417,610 (-)NCBIGRCr8
mRatBN7.21537,234,662 - 37,241,621 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,234,751 - 37,235,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,099,940 - 39,106,775 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,250,746 - 40,257,581 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,695,393 - 38,702,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,159,511 - 46,166,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,159,511 - 46,166,335 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,925,455 - 49,932,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,247,668 - 42,254,485 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1536,920,462 - 36,927,279 (-)NCBICelera
Cytogenetic Map15p12NCBI
DEFB109B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11653,914,753 - 53,954,742 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1649,418,450 - 49,458,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01656,229,055 - 56,268,947 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11654,124,609 - 54,142,590 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01654,721,310 - 54,739,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01654,956,864 - 54,974,852 (-)NCBIUU_Cfam_GSD_1.0
DEFB109B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023670491169 - 869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Defb48
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:60
Interacting mature miRNAs:70
Transcripts:ENSMUST00000100493
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000100493   ⟹   ENSMUSP00000098062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1463,214,973 - 63,221,959 (-)Ensembl
GRCm38.p6 Ensembl1462,977,524 - 62,984,510 (-)Ensembl
RefSeq Acc Id: NM_001037751   ⟹   NP_001032840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391463,214,974 - 63,221,959 (-)NCBI
GRCm381462,977,524 - 62,984,510 (-)ENTREZGENE
MGSCv371463,596,361 - 63,603,347 (-)RGD
Celera1460,736,259 - 60,743,070 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001032840 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI45919 (Get FASTA)   NCBI Sequence Viewer  
  AAI45921 (Get FASTA)   NCBI Sequence Viewer  
  AAY59780 (Get FASTA)   NCBI Sequence Viewer  
  BAE23097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000098062
  ENSMUSP00000098062.3
Reference Protein Sequences
RefSeq Acc Id: NP_001032840   ⟸   NM_001037751
- Peptide Label: precursor
- UniProtKB: Q3UW22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098062   ⟸   ENSMUST00000100493

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UW22-F1-model_v2 AlphaFold Q3UW22 1-87 view protein structure

Promoters
RGD ID:8682678
Promoter ID:EPDNEW_M19369
Type:multiple initiation site
Name:Defb48_1
Description:Mus musculus defensin beta 48 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381462,984,510 - 62,984,570EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3646223 AgrOrtholog
Ensembl Genes ENSMUSG00000075574 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000100493 ENTREZGENE
  ENSMUST00000100493.3 UniProtKB/TrEMBL
InterPro Defensin_beta-typ UniProtKB/TrEMBL
KEGG Report mmu:432867 UniProtKB/TrEMBL
MGD MGI:3646223 ENTREZGENE
NCBI Gene 432867 ENTREZGENE
PANTHER BETA-DEFENSIN UniProtKB/TrEMBL
  BETA-DEFENSIN 109B-RELATED UniProtKB/TrEMBL
Pfam Defensin_beta UniProtKB/TrEMBL
PhenoGen Defb48 PhenoGen
UniProt Q3UW22 ENTREZGENE, UniProtKB/TrEMBL