Fundc1 (FUN14 domain containing 1) - Rat Genome Database

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Gene: Fundc1 (FUN14 domain containing 1) Mus musculus
Analyze
Symbol: Fundc1
Name: FUN14 domain containing 1
RGD ID: 1557033
MGI Page MGI
Description: Predicted to be involved in mitophagy and response to hypoxia. Predicted to act upstream of or within autophagy. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in thymus primordium. Orthologous to human FUNDC1 (FUN14 domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500005J14Rik; 1810033P05Rik; FUN14 domain-containing protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X17,386,206 - 17,438,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX17,422,803 - 17,438,564 (-)EnsemblGRCm39 Ensembl
GRCm38X17,519,967 - 17,572,329 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX17,556,564 - 17,572,325 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X17,133,695 - 17,149,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X16,713,528 - 16,729,256 (-)NCBIMGSCv36mm8
CeleraX15,168,138 - 15,183,866 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX12.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Liu L, etal., Nat Cell Biol. 2012 Jan 22;14(2):177-85. doi: 10.1038/ncb2422.
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
7. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Zhang W, etal., Elife. 2016 Dec 20;5. pii: e21407. doi: 10.7554/eLife.21407.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:24573672   PMID:24652767   PMID:24671035   PMID:25980607   PMID:28323531   PMID:28732308   PMID:28942427   PMID:29540794   PMID:29719250   PMID:30053328   PMID:30646747  
PMID:30741592   PMID:30898010   PMID:30973865   PMID:31237014   PMID:32938669   PMID:33182075   PMID:33554448   PMID:33942716   PMID:34022268   PMID:34331963   PMID:34921980   PMID:35410319  
PMID:35422895   PMID:35864106   PMID:36470869   PMID:36828120   PMID:37030149   PMID:37336125   PMID:37691112   PMID:38305334   PMID:38355793  


Genomics

Comparative Map Data
Fundc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X17,386,206 - 17,438,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX17,422,803 - 17,438,564 (-)EnsemblGRCm39 Ensembl
GRCm38X17,519,967 - 17,572,329 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX17,556,564 - 17,572,325 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X17,133,695 - 17,149,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X16,713,528 - 16,729,256 (-)NCBIMGSCv36mm8
CeleraX15,168,138 - 15,183,866 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX12.8NCBI
FUNDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X44,523,639 - 44,542,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX44,523,639 - 44,542,859 (-)EnsemblGRCh38hg38GRCh38
GRCh37X44,382,885 - 44,402,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X44,267,847 - 44,287,160 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X44,139,158 - 44,158,470NCBI
CeleraX48,519,971 - 48,539,287 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX42,105,885 - 42,125,812 (-)NCBIHuRef
CHM1_1X44,415,841 - 44,435,193 (-)NCBICHM1_1
T2T-CHM13v2.0X43,930,462 - 43,949,676 (-)NCBIT2T-CHM13v2.0
Fundc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X7,666,787 - 7,683,443 (+)NCBIGRCr8
mRatBN7.2X5,083,635 - 5,100,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,083,617 - 5,100,284 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX5,136,794 - 5,153,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X8,612,588 - 8,629,261 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X4,932,812 - 4,949,480 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X5,549,468 - 5,566,125 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX5,549,419 - 5,566,127 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X6,329,908 - 6,346,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X16,672,818 - 16,689,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX5,589,536 - 5,606,194 (+)NCBICelera
Cytogenetic MapXq11NCBI
Fundc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555163,648,629 - 3,664,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555163,648,629 - 3,664,032 (+)NCBIChiLan1.0ChiLan1.0
FUNDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X46,169,288 - 46,188,398 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X46,172,661 - 46,191,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X36,970,051 - 36,989,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X44,790,550 - 44,809,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,790,550 - 44,809,793 (-)Ensemblpanpan1.1panPan2
FUNDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X38,492,470 - 38,505,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX38,492,720 - 38,505,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX25,720,234 - 25,733,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X38,581,261 - 38,594,306 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX38,577,447 - 38,594,178 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X38,614,716 - 38,627,760 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X38,594,940 - 38,607,984 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X38,693,558 - 38,706,604 (-)NCBIUU_Cfam_GSD_1.0
Fundc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,803,266 - 30,816,345 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650210,643,071 - 10,657,134 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650210,643,172 - 10,657,118 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUNDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,724,998 - 39,737,532 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,726,194 - 39,737,663 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X44,109,888 - 44,121,363 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FUNDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X41,685,945 - 41,705,037 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660766,906,483 - 6,926,162 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fundc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624887626,321 - 641,293 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624887626,321 - 641,296 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fundc1
1203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:742
Count of miRNA genes:365
Interacting mature miRNAs:392
Transcripts:ENSMUST00000026016, ENSMUST00000127690, ENSMUST00000142638, ENSMUST00000176638, ENSMUST00000177213
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse

Markers in Region
AW107505  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X17,556,812 - 17,556,905UniSTSGRCm38
MGSCv37X17,133,938 - 17,134,031UniSTSGRCm37
CeleraX15,168,381 - 15,168,474UniSTS
Cytogenetic MapXA2UniSTS
Whitehead/MRC_RHX253.92UniSTS
Whitehead/MRC_RHX246.7UniSTS
UniSTS:238008  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X17,557,752 - 17,557,934UniSTSGRCm38
MGSCv37X17,134,878 - 17,135,060UniSTSGRCm37
CeleraX15,169,322 - 15,169,504UniSTS
Cytogenetic MapXA2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026016   ⟹   ENSMUSP00000026016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX17,422,803 - 17,438,564 (-)Ensembl
GRCm38.p6 EnsemblX17,556,564 - 17,572,325 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX17,424,137 - 17,437,863 (-)Ensembl
GRCm38.p6 EnsemblX17,557,898 - 17,571,624 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142638   ⟹   ENSMUSP00000135026
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX17,424,155 - 17,438,246 (-)Ensembl
GRCm38.p6 EnsemblX17,557,916 - 17,572,007 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176638   ⟹   ENSMUSP00000135183
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX17,424,137 - 17,438,492 (-)Ensembl
GRCm38.p6 EnsemblX17,557,898 - 17,572,253 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177213   ⟹   ENSMUSP00000134878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX17,423,763 - 17,437,880 (-)Ensembl
GRCm38.p6 EnsemblX17,557,524 - 17,571,641 (-)Ensembl
RefSeq Acc Id: NM_001313745   ⟹   NP_001300674
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X17,421,839 - 17,438,564 (-)NCBI
GRCm38X17,555,600 - 17,572,325 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313746   ⟹   NP_001300675
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X17,421,839 - 17,438,246 (-)NCBI
GRCm38X17,555,600 - 17,572,007 (-)NCBI
Sequence:
RefSeq Acc Id: NM_028058   ⟹   NP_082334
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X17,421,839 - 17,438,564 (-)NCBI
GRCm38X17,555,600 - 17,572,325 (-)NCBI
MGSCv37X17,133,695 - 17,149,423 (-)RGD
CeleraX15,168,138 - 15,183,866 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011247496   ⟹   XP_011245798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X17,386,206 - 17,438,600 (-)NCBI
GRCm38X17,519,967 - 17,572,329 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082334   ⟸   NM_028058
- Peptide Label: isoform 1
- UniProtKB: A2BEA3 (UniProtKB/Swiss-Prot),   Q9DB70 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245798   ⟸   XM_011247496
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001300674   ⟸   NM_001313745
- Peptide Label: isoform 2
- UniProtKB: H3BJZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300675   ⟸   NM_001313746
- Peptide Label: isoform 3
- UniProtKB: H3BJ77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026016   ⟸   ENSMUST00000026016
RefSeq Acc Id: ENSMUSP00000134878   ⟸   ENSMUST00000177213
RefSeq Acc Id: ENSMUSP00000135183   ⟸   ENSMUST00000176638
RefSeq Acc Id: ENSMUSP00000135026   ⟸   ENSMUST00000142638

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DB70-F1-model_v2 AlphaFold Q9DB70 1-155 view protein structure

Promoters
RGD ID:6845727
Promoter ID:MM_KWN:59683
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041098,   OTTMUST00000041099,   OTTMUST00000041100,   UC009SSF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X17,148,576 - 17,149,552 (-)MPROMDB
RGD ID:13680150
Promoter ID:EPDNEW_M24224
Type:multiple initiation site
Name:Fundc1_1
Description:Mus musculus FUN14 domain containing 1 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X17,572,192 - 17,572,252EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919268 AgrOrtholog
Ensembl Genes ENSMUSG00000025040 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026016 ENTREZGENE
  ENSMUST00000026016.13 UniProtKB/Swiss-Prot
  ENSMUST00000142638 ENTREZGENE
  ENSMUST00000142638.2 UniProtKB/TrEMBL
  ENSMUST00000176638 ENTREZGENE
  ENSMUST00000176638.8 UniProtKB/TrEMBL
  ENSMUST00000177213.8 UniProtKB/TrEMBL
InterPro FUN14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72018 UniProtKB/Swiss-Prot
MGD MGI:1919268 ENTREZGENE
NCBI Gene 72018 ENTREZGENE
PANTHER FUN14 DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21346 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FUN14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fundc1 PhenoGen
UniProt A2BEA3 ENTREZGENE
  FUND1_MOUSE UniProtKB/Swiss-Prot
  H3BJ77 ENTREZGENE, UniProtKB/TrEMBL
  H3BJZ1 ENTREZGENE, UniProtKB/TrEMBL
  Q9DB70 ENTREZGENE
UniProt Secondary A2BEA3 UniProtKB/Swiss-Prot