Wasl (WASP like actin nucleation promoting factor) - Rat Genome Database

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Gene: Wasl (WASP like actin nucleation promoting factor) Mus musculus
Analyze
Symbol: Wasl
Name: WASP like actin nucleation promoting factor
RGD ID: 1553011
MGI Page MGI
Description: Predicted to enable cytoskeletal protein binding activity and identical protein binding activity. Involved in dendritic spine morphogenesis and regulation of postsynapse organization. Acts upstream of or within several processes, including actin cytoskeleton organization; response to bacterium; and spindle localization. Located in actin cap and lamellipodium. Is active in glutamatergic synapse. Is expressed in brain; genitourinary system; liver; and spleen. Used to study atopic dermatitis. Orthologous to human WASL (WASP like actin nucleation promoting factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2900021I12Rik; 3110031I02Rik; actin nucleation-promoting factor WASL; N-; N-WASP; neural Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,613,809 - 24,665,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,613,804 - 24,665,008 (-)EnsemblGRCm39 Ensembl
GRCm38624,613,810 - 24,664,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37624,563,810 - 24,614,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,563,815 - 24,614,981 (-)NCBIMGSCv36mm8
Celera624,624,846 - 24,676,054 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chloroprene  (ISO)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
levofloxacin  (ISO)
MeIQx  (ISO)
Mesaconitine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
testosterone enanthate  (ISO)
tetraphene  (EXP)
thimerosal  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal brain ependyma morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cell chemotaxis  (IAGP)
abnormal cerebral aqueduct morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal dorsal striatum morphology  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal ectoplacental cavity morphology  (IAGP)
abnormal esophagus morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal gait  (IAGP)
abnormal gastrulation  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal septum of telencephalon morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal spine curvature  (IAGP)
abnormal thymocyte activation  (IAGP)
absent brain ependyma motile cilia  (IAGP)
absent heartbeat  (IAGP)
absent hippocampus  (IAGP)
alopecia  (IAGP)
astrocytosis  (IAGP)
cerebral aqueductal stenosis  (IAGP)
colitis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased corpus callosum size  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased renal tubule number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
delayed embryo turning  (IAGP)
dermatitis  (IAGP)
dilated esophagus  (IAGP)
dilated fourth ventricle  (IAGP)
dilated heart  (IAGP)
dilated lateral ventricle  (IAGP)
domed cranium  (IAGP)
dry skin  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged brain ventricles  (IAGP)
enlarged cranium  (IAGP)
epidermal hyperplasia  (IAGP)
failure of initiation of embryo turning  (IAGP)
hydrocephaly  (IAGP)
impaired skin barrier function  (IAGP)
increased brain size  (IAGP)
increased circulating interleukin-1 alpha level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased single-positive T cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
kyphosis  (IAGP)
lethargy  (IAGP)
no abnormal phenotype detected  (IAGP)
obstructive hydrocephaly  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
renal hypoplasia  (IAGP)
scaly skin  (IAGP)
skin inflammation  (IAGP)
thick epidermis  (IAGP)
thin cerebral cortex  (IAGP)
wavy neural tube  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11082044   PMID:11130076   PMID:11157975   PMID:11559594   PMID:11584271   PMID:12477732   PMID:12477932   PMID:12520002   PMID:12871950  
PMID:14506234   PMID:14610273   PMID:14697212   PMID:15085951   PMID:15123724   PMID:15148305   PMID:15169891   PMID:15247266   PMID:15496413   PMID:15585574   PMID:15592455   PMID:15684033  
PMID:15688017   PMID:15699051   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16723544   PMID:17182853   PMID:17419995   PMID:17573773   PMID:17878299   PMID:17963692   PMID:18287559  
PMID:18448434   PMID:18462674   PMID:18799693   PMID:19741094   PMID:19759398   PMID:19778379   PMID:19917259   PMID:20016073   PMID:20059953   PMID:20071778   PMID:20146487   PMID:20150425  
PMID:20392836   PMID:20599953   PMID:20678498   PMID:21148086   PMID:21148390   PMID:21263026   PMID:21267068   PMID:21385763   PMID:21427700   PMID:21652648   PMID:21725061   PMID:21873635  
PMID:21874009   PMID:21898535   PMID:21924960   PMID:22411869   PMID:22454526   PMID:22736793   PMID:22886502   PMID:22966049   PMID:22989773   PMID:23295348   PMID:23437151   PMID:23471198  
PMID:23549080   PMID:23555292   PMID:23707428   PMID:23867458   PMID:24223520   PMID:24385601   PMID:24449844   PMID:24462670   PMID:24481817   PMID:24698977   PMID:24861867   PMID:24967734  
PMID:25262827   PMID:25851601   PMID:25982384   PMID:25987543   PMID:26496209   PMID:27025963   PMID:27143109   PMID:27909303   PMID:27965114   PMID:28057438   PMID:28779153   PMID:29650963  
PMID:29672847   PMID:29785947   PMID:29887380   PMID:30894371   PMID:31405607   PMID:31751919   PMID:31916311   PMID:31974357   PMID:32325033   PMID:32434991   PMID:32601246   PMID:32646006  
PMID:33545089   PMID:35449600   PMID:36830748   PMID:37760426   PMID:38085658   PMID:38560567  


Genomics

Comparative Map Data
Wasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,613,809 - 24,665,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,613,804 - 24,665,008 (-)EnsemblGRCm39 Ensembl
GRCm38624,613,810 - 24,664,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37624,563,810 - 24,614,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,563,815 - 24,614,981 (-)NCBIMGSCv36mm8
Celera624,624,846 - 24,676,054 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
WASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,681,943 - 123,749,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,681,943 - 123,749,003 (-)EnsemblGRCh38hg38GRCh38
GRCh377123,321,997 - 123,389,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,109,233 - 123,176,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 347122,915,949 - 122,983,067NCBI
Celera7118,125,741 - 118,192,900 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,685,121 - 117,752,321 (-)NCBIHuRef
CHM1_17123,255,296 - 123,322,481 (-)NCBICHM1_1
T2T-CHM13v2.07124,998,697 - 125,065,742 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,710,608 - 122,777,749 (-)NCBI
Wasl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,049,081 - 54,097,653 (-)NCBIGRCr8
mRatBN7.2453,083,536 - 53,132,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx458,070,385 - 58,118,872 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,977,276 - 54,025,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,411,758 - 52,460,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,677,722 - 51,726,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,455,978 - 51,504,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4451,063,710 - 51,092,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1451,294,288 - 51,323,128 (-)NCBI
Celera448,249,249 - 48,297,692 (-)NCBICelera
Cytogenetic Map4q22NCBI
Wasl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554795,166,393 - 5,200,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554795,167,851 - 5,200,512 (-)NCBIChiLan1.0ChiLan1.0
WASL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,537,416 - 160,606,388 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,550,222 - 12,614,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,675,170 - 115,741,498 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,357,909 - 128,388,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,360,495 - 128,385,393 (-)Ensemblpanpan1.1panPan2
WASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,828,298 - 11,901,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,828,687 - 11,899,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1411,512,373 - 11,585,271 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01411,605,958 - 11,678,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,606,343 - 11,678,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,795,524 - 11,868,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,533,495 - 11,606,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,774,079 - 11,846,981 (+)NCBIUU_Cfam_GSD_1.0
Wasl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,318,931 - 25,386,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,480,392 - 92,546,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,482,918 - 92,546,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604210,917,558 - 10,985,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wasl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478312,254,715 - 12,323,232 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478312,239,467 - 12,322,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wasl
1445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1021
Count of miRNA genes:579
Interacting mature miRNAs:713
Transcripts:ENSMUST00000031695, ENSMUST00000041737, ENSMUST00000173399
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001167745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ318416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX567238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH244369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000031695   ⟹   ENSMUSP00000031695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,613,804 - 24,665,008 (-)Ensembl
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)Ensembl
RefSeq Acc Id: ENSMUST00000041737   ⟹   ENSMUSP00000043968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,632,684 - 24,664,987 (-)Ensembl
GRCm38.p6 Ensembl624,632,685 - 24,664,988 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,637,854 - 24,664,937 (-)Ensembl
GRCm38.p6 Ensembl624,637,855 - 24,664,938 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201867
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,626,662 - 24,628,072 (-)Ensembl
GRCm38.p6 Ensembl624,626,663 - 24,628,073 (-)Ensembl
RefSeq Acc Id: NM_001167745   ⟹   NP_001161217
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,632,685 - 24,664,994 (-)NCBI
GRCm38624,632,686 - 24,664,995 (-)NCBI
MGSCv37624,563,810 - 24,614,995 (-)RGD
Celera624,624,846 - 24,676,054 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_028459   ⟹   NP_082735
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,613,809 - 24,664,994 (-)NCBI
GRCm38624,613,810 - 24,664,995 (-)ENTREZGENE
MGSCv37624,563,810 - 24,614,995 (-)RGD
Celera624,624,846 - 24,676,054 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036152346   ⟹   XP_036008239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,622,974 - 24,665,185 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082735   ⟸   NM_028459
- Peptide Label: isoform 1
- UniProtKB: Q91YD9 (UniProtKB/Swiss-Prot),   Q3TXX8 (UniProtKB/TrEMBL),   Q7TPN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001161217   ⟸   NM_001167745
- Peptide Label: isoform 2
- UniProtKB: Q9CXQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031695   ⟸   ENSMUST00000031695
RefSeq Acc Id: ENSMUSP00000043968   ⟸   ENSMUST00000041737
RefSeq Acc Id: XP_036008239   ⟸   XM_036152346
- Peptide Label: isoform X1
Protein Domains
CRIB   WH1   WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91YD9-F1-model_v2 AlphaFold Q91YD9 1-501 view protein structure

Promoters
RGD ID:6848045
Promoter ID:MM_ACW:40659
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:WASL.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36624,569,446 - 24,569,946 (-)MPROMDB
RGD ID:6840154
Promoter ID:MM_KWN:45307
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001167745,   NM_028459_WASL
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36624,614,844 - 24,615,344 (-)MPROMDB
RGD ID:6889116
Promoter ID:EPDNEW_M8009
Type:initiation region
Name:Wasl_1
Description:Mus musculus Wiskott-Aldrich syndrome-like , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38624,664,988 - 24,665,048EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920428 AgrOrtholog
Ensembl Genes ENSMUSG00000029684 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031695 ENTREZGENE
  ENSMUST00000031695.15 UniProtKB/Swiss-Prot
  ENSMUST00000041737 ENTREZGENE
  ENSMUST00000041737.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WASP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WASPfam_EVH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73178 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920428 ENTREZGENE
NCBI Gene 73178 ENTREZGENE
PANTHER NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wasl PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47912 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q05CX6_MOUSE UniProtKB/TrEMBL
  Q3TXX8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UGK7_MOUSE UniProtKB/TrEMBL
  Q3UMN0_MOUSE UniProtKB/TrEMBL
  Q3UQ99_MOUSE UniProtKB/TrEMBL
  Q3USR1_MOUSE UniProtKB/TrEMBL
  Q6PDL3_MOUSE UniProtKB/TrEMBL
  Q7TPN5 ENTREZGENE, UniProtKB/TrEMBL
  Q80VV6_MOUSE UniProtKB/TrEMBL
  Q91YD9 ENTREZGENE
  Q9CXQ9 ENTREZGENE, UniProtKB/TrEMBL
  WASL_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-04 Wasl  WASP like actin nucleation promoting factor  Wasl  Wiskott-Aldrich syndrome-like (human)  Symbol and/or name change 5135510 APPROVED