Wasl (WASP like actin nucleation promoting factor) - Rat Genome Database

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Gene: Wasl (WASP like actin nucleation promoting factor) Ictidomys tridecemlineatus
Analyze
Symbol: Wasl
Name: WASP like actin nucleation promoting factor
RGD ID: 12694228
Description: ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell projection assembly (ortholog); membrane invagination (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); FOUND IN cell leading edge (ortholog); cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Wiskott-Aldrich syndrome like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wasl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,681,943 - 123,749,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,681,943 - 123,749,003 (-)EnsemblGRCh38hg38GRCh38
GRCh377123,321,997 - 123,389,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,109,233 - 123,176,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 347122,915,949 - 122,983,067NCBI
Celera7118,125,741 - 118,192,900 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,685,121 - 117,752,321 (-)NCBIHuRef
CHM1_17123,255,296 - 123,322,481 (-)NCBICHM1_1
T2T-CHM13v2.07124,998,697 - 125,065,742 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,710,608 - 122,777,749 (-)NCBI
Wasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,613,809 - 24,665,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,613,804 - 24,665,008 (-)EnsemblGRCm39 Ensembl
GRCm38624,613,810 - 24,664,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37624,563,810 - 24,614,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,563,815 - 24,614,981 (-)NCBIMGSCv36mm8
Celera624,624,846 - 24,676,054 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
Wasl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,049,081 - 54,097,653 (-)NCBIGRCr8
mRatBN7.2453,083,536 - 53,132,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx458,070,385 - 58,118,872 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,977,276 - 54,025,972 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,411,758 - 52,460,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,677,722 - 51,726,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,455,978 - 51,504,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4451,063,710 - 51,092,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1451,294,288 - 51,323,128 (-)NCBI
Celera448,249,249 - 48,297,692 (-)NCBICelera
Cytogenetic Map4q22NCBI
Wasl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554795,166,393 - 5,200,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554795,167,851 - 5,200,512 (-)NCBIChiLan1.0ChiLan1.0
WASL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,537,416 - 160,606,388 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,550,222 - 12,614,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,675,170 - 115,741,498 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,357,909 - 128,388,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,360,495 - 128,385,393 (-)Ensemblpanpan1.1panPan2
WASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,828,298 - 11,901,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,828,687 - 11,899,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1411,512,373 - 11,585,271 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01411,605,958 - 11,678,914 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,606,343 - 11,678,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,795,524 - 11,868,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,533,495 - 11,606,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,774,079 - 11,846,981 (+)NCBIUU_Cfam_GSD_1.0
WASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,318,931 - 25,386,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,480,392 - 92,546,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,482,918 - 92,546,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604210,917,558 - 10,985,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wasl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478312,254,715 - 12,323,232 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478312,239,467 - 12,322,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000001894   ⟹   ENSSTOP00000001688
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)Ensembl
RefSeq Acc Id: XM_005333934   ⟹   XP_005333991
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511850,387,234 - 50,461,159 (-)NCBI
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040291613   ⟹   XP_040147547
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005333991 (Get FASTA)   NCBI Sequence Viewer  
  XP_040147547 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001688.2
GenBank Protein KAG3277727 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005333991   ⟸   XM_005333934
- Peptide Label: isoform X1
- UniProtKB: I3LZE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040147547   ⟸   XM_040291613
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000001688   ⟸   ENSSTOT00000001894
Protein Domains
CRIB   WH1   WH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001892 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001894.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.90.810.10 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  WASP_C UniProtKB/TrEMBL
  WASPfam_EVH1 UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/TrEMBL
  WH2_dom UniProtKB/TrEMBL
NCBI Gene Wasl ENTREZGENE
PANTHER NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN UniProtKB/TrEMBL
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
  WH1 UniProtKB/TrEMBL
  WH2 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47912 UniProtKB/TrEMBL
UniProt I3LZE3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Wasl  WASP like actin nucleation promoting factor    Wiskott-Aldrich syndrome like  Symbol and/or name change 5135510 APPROVED