CASP8AP2 (caspase 8 associated protein 2) - Rat Genome Database

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Gene: CASP8AP2 (caspase 8 associated protein 2) Sus scrofa
Analyze
Symbol: CASP8AP2
Name: caspase 8 associated protein 2
RGD ID: 14233479
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); extrinsic apoptotic signaling pathway via death domain receptors (ortholog); PARTICIPATES IN aldosterone signaling pathway; FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CASP8-associated protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,835,145 - 57,862,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,834,251 - 57,864,837 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,689,689 - 64,811,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
membrane  (IEA)
mitochondrion  (IBA,IEA)
nucleus  (IEA)
PML body  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CASP8AP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,835,145 - 57,862,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,834,251 - 57,864,837 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,689,689 - 64,811,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP8AP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38689,829,880 - 89,874,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl689,829,894 - 89,874,436 (+)EnsemblGRCh38hg38GRCh38
GRCh37690,539,599 - 90,584,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,596,379 - 90,640,876 (+)NCBINCBI36Build 36hg18NCBI36
Build 34690,596,378 - 90,640,875NCBI
Celera690,958,564 - 91,004,713 (+)NCBICelera
Cytogenetic Map6q15NCBI
HuRef687,756,992 - 87,803,539 (+)NCBIHuRef
CHM1_1690,637,186 - 90,681,833 (+)NCBICHM1_1
T2T-CHM13v2.0691,029,094 - 91,086,157 (+)NCBIT2T-CHM13v2.0
Casp8ap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39432,615,462 - 32,653,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl432,615,451 - 32,653,265 (+)EnsemblGRCm39 Ensembl
GRCm38432,615,470 - 32,653,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl432,615,451 - 32,653,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,702,448 - 32,740,240 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,944,126 - 32,981,873 (+)NCBIMGSCv36mm8
Celera432,362,733 - 32,400,576 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.27NCBI
Casp8ap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,809,366 - 51,848,633 (+)NCBIGRCr8
mRatBN7.2547,014,501 - 47,052,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl547,014,667 - 47,052,275 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx549,156,788 - 49,194,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,755,948 - 50,793,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,701,113 - 50,738,716 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0547,853,699 - 47,891,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,853,818 - 47,891,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,451,775 - 52,489,186 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,920,175 - 48,958,139 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1548,928,473 - 49,096,830 (+)NCBI
Celera545,775,811 - 45,813,420 (+)NCBICelera
Cytogenetic Map5q21NCBI
Casp8ap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541116,535,646 - 16,568,139 (-)NCBIChiLan1.0ChiLan1.0
CASP8AP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25109,912,615 - 109,959,693 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16107,811,413 - 107,860,815 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0687,707,152 - 87,754,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1690,979,710 - 91,026,770 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl690,996,127 - 91,023,757 (+)Ensemblpanpan1.1panPan2
CASP8AP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11249,040,069 - 49,077,418 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,039,411 - 49,077,688 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,847,072 - 48,884,174 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01249,849,389 - 49,886,726 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1249,849,439 - 49,884,151 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11249,164,550 - 49,201,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01249,065,265 - 49,102,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,257,627 - 49,294,727 (+)NCBIUU_Cfam_GSD_1.0
Casp8ap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494684,022,998 - 84,049,994 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365102,420,920 - 2,447,986 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365102,420,924 - 2,447,634 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8AP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11314,586,857 - 14,632,384 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1314,586,929 - 14,632,362 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040190,973,325 - 191,019,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp8ap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247994,302,738 - 4,353,211 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CASP8AP2
723 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 4 3 1
Low 9 2 3 1 2 20 2 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004783   ⟹   ENSSSCP00000004671
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl157,843,048 - 57,860,163 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000004787   ⟹   ENSSSCP00000004675
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl157,835,145 - 57,862,473 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050370   ⟹   ENSSSCP00000032630
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl157,834,116 - 57,864,844 (+)Ensembl
RefSeq Acc Id: XM_005659298   ⟹   XP_005659355
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,251 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090028   ⟹   XP_020945687
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,255 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090036   ⟹   XP_020945695
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,299 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090042   ⟹   XP_020945701
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,299 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090045   ⟹   XP_020945704
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,637 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090047   ⟹   XP_020945706
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,299 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090053   ⟹   XP_020945712
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,298 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090057   ⟹   XP_020945716
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,255 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090064   ⟹   XP_020945723
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,298 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090069   ⟹   XP_020945728
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,285 - 57,864,837 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090076   ⟹   XP_020945735
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1157,834,255 - 57,862,477 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005659355   ⟸   XM_005659298
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945716   ⟸   XM_021090057
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945687   ⟸   XM_021090028
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945735   ⟸   XM_021090076
- Peptide Label: isoform X2
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945728   ⟸   XM_021090069
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945712   ⟸   XM_021090053
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945723   ⟸   XM_021090064
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945701   ⟸   XM_021090042
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945695   ⟸   XM_021090036
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945706   ⟸   XM_021090047
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945704   ⟸   XM_021090045
- Peptide Label: isoform X1
- UniProtKB: A0A8D1PLS8 (UniProtKB/TrEMBL),   A0A4X1VDZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032630   ⟸   ENSSSCT00000050370
RefSeq Acc Id: ENSSSCP00000004671   ⟸   ENSSSCT00000004783
RefSeq Acc Id: ENSSSCP00000004675   ⟸   ENSSSCT00000004787


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020125 UniProtKB/TrEMBL
  ENSSSCG00025070369 UniProtKB/TrEMBL
  ENSSSCG00030015843 UniProtKB/TrEMBL
  ENSSSCG00035075502 UniProtKB/TrEMBL
  ENSSSCG00040057069 UniProtKB/TrEMBL
  ENSSSCG00045032723 UniProtKB/TrEMBL
  ENSSSCG00055003666 UniProtKB/TrEMBL
  ENSSSCG00065066242 UniProtKB/TrEMBL
  ENSSSCG00070024612 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004787 ENTREZGENE
  ENSSSCT00000004787.6 UniProtKB/TrEMBL
  ENSSSCT00005031713.1 UniProtKB/TrEMBL
  ENSSSCT00005031730.1 UniProtKB/TrEMBL
  ENSSSCT00025096615.1 UniProtKB/TrEMBL
  ENSSSCT00030021964.1 UniProtKB/TrEMBL
  ENSSSCT00030021978.1 UniProtKB/TrEMBL
  ENSSSCT00030021983.1 UniProtKB/TrEMBL
  ENSSSCT00030022000.1 UniProtKB/TrEMBL
  ENSSSCT00035102614.1 UniProtKB/TrEMBL
  ENSSSCT00040077297.1 UniProtKB/TrEMBL
  ENSSSCT00040077382.1 UniProtKB/TrEMBL
  ENSSSCT00045055846.1 UniProtKB/TrEMBL
  ENSSSCT00055007201.1 UniProtKB/TrEMBL
  ENSSSCT00065090908.1 UniProtKB/TrEMBL
  ENSSSCT00070049113.1 UniProtKB/TrEMBL
  ENSSSCT00070049117.1 UniProtKB/TrEMBL
  ENSSSCT00070049119.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro FLASH UniProtKB/TrEMBL
  Gon4l/CASP8AP2_myb-like UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
KEGG Report ssc:100523759 UniProtKB/TrEMBL
NCBI Gene CASP8AP2 ENTREZGENE
PANTHER CASP8-ASSOCIATED PROTEIN 2 UniProtKB/TrEMBL
  PTHR15489 UniProtKB/TrEMBL
Pfam Myb_DNA-binding_7 UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A4X1VDZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VJ30_PIG UniProtKB/TrEMBL
  A0A4X1VKQ1_PIG UniProtKB/TrEMBL
  A0A8D0IV53_PIG UniProtKB/TrEMBL
  A0A8D0IVW1_PIG UniProtKB/TrEMBL
  A0A8D0VQR9_PIG UniProtKB/TrEMBL
  A0A8D0VRL6_PIG UniProtKB/TrEMBL
  A0A8D0VRT3_PIG UniProtKB/TrEMBL
  A0A8D0VT88_PIG UniProtKB/TrEMBL
  A0A8D1D515_PIG UniProtKB/TrEMBL
  A0A8D1F6X1_PIG UniProtKB/TrEMBL
  A0A8D1FAG9_PIG UniProtKB/TrEMBL
  A0A8D1IUU4_PIG UniProtKB/TrEMBL
  A0A8D1PLS8 ENTREZGENE, UniProtKB/TrEMBL
  F1RY19_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86204 ENTREZGENE