Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | EXP | | 6480464 | Demecolcine results in decreased expression of PLEKHA2 mRNA | CTD | PMID:23649840 | 1,2-dichloroethane | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of PLEKHA2 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PLEKHA2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | Plekha2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PLEKHA2 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PLEKHA2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of PLEKHA2 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekha2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLEKHA2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA2 mRNA | CTD | PMID:34747641 | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PLEKHA2 mRNA | CTD | PMID:30851411 | 2-palmitoylglycerol | increases expression | EXP | | 6480464 | 2-palmitoylglycerol results in increased expression of PLEKHA2 mRNA | CTD | PMID:37199045 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PLEKHA2 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PLEKHA2 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of PLEKHA2 mRNA | CTD | PMID:27685785 | 4,4'-sulfonyldiphenol | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PLEKHA2 mRNA | CTD | PMID:30951980 | 5-aza-2'-deoxycytidine | affects expression | EXP | | 6480464 | Decitabine affects the expression of PLEKHA2 mRNA | CTD | PMID:23300844 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of PLEKHA2 mRNA | CTD | PMID:33167477 | alpha-Zearalanol | increases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Zeranol results in increased expression of PLEKHA2 mRNA | CTD | PMID:35163327 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of PLEKHA2 mRNA | CTD | PMID:33212167 | belinostat | decreases expression | EXP | | 6480464 | belinostat results in decreased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PLEKHA2 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of PLEKHA2 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of PLEKHA2 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PLEKHA2 mRNA | CTD | PMID:27195522 | benzo[a]pyrene | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PLEKHA2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PLEKHA2 protein | CTD | PMID:32717239 | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 more ... | bisphenol A | affects expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of PLEKHA2 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PLEKHA2 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PLEKHA2 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of PLEKHA2 mRNA | CTD | PMID:30951980 | butan-1-ol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PLEKHA2 mRNA | CTD | PMID:29432896 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLEKHA2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLEKHA2 mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | EXP | | 6480464 | Caffeine results in decreased phosphorylation of PLEKHA2 protein | CTD | PMID:35688186 | calcitriol | increases expression | EXP | | 6480464 | Calcitriol results in increased expression of PLEKHA2 mRNA | CTD | PMID:16002434 | carbon nanotube | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of PLEKHA2 mRNA | CTD | PMID:25554681 | choline | multiple interactions | ISO | Plekha2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA2 mRNA | CTD | PMID:20938992 | cisplatin | affects expression | EXP | | 6480464 | Cisplatin affects the expression of PLEKHA2 mRNA | CTD | PMID:23300844 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PLEKHA2 mRNA | CTD | PMID:20106945 more ... | dioxygen | increases expression | EXP | | 6480464 | Oxygen deficiency results in increased expression of PLEKHA2 mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of PLEKHA2 mRNA | CTD | PMID:29803840 | entinostat | increases expression | EXP | | 6480464 | entinostat results in increased expression of PLEKHA2 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | ethanol | multiple interactions | EXP | | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PLEKHA2 mRNA and [Ethanol co-treated with Folic Acid] results in increased expression of PLEKHA2 mRNA | CTD | PMID:23378141 and PMID:29432896 | ethanol | affects expression | ISO | Plekha2 (Mus musculus) | 6480464 | Ethanol affects the expression of PLEKHA2 mRNA | CTD | PMID:30319688 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of PLEKHA2 mRNA | CTD | PMID:23378141 | fluoranthene | multiple interactions | ISO | Plekha2 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in decreased expression of PLEKHA2 mRNA | CTD | PMID:28329830 | folic acid | multiple interactions | ISO | Plekha2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA2 mRNA | CTD | PMID:20938992 | folic acid | multiple interactions | EXP | | 6480464 | [Ethanol co-treated with Folic Acid] results in increased expression of PLEKHA2 mRNA | CTD | PMID:23378141 | formaldehyde | decreases expression | EXP | | 6480464 | Formaldehyde results in decreased expression of PLEKHA2 mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | EXP | | 6480464 | FR900359 results in decreased phosphorylation of PLEKHA2 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PLEKHA2 mRNA | CTD | PMID:33387578 | glyphosate | affects methylation | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Glyphosate affects the methylation of PLEKHA2 gene | CTD | PMID:35440735 | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of PLEKHA2 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Plekha2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA2 mRNA | CTD | PMID:20938992 | Licochalcone B | decreases expression | EXP | | 6480464 | licochalcone B results in decreased expression of PLEKHA2 mRNA | CTD | PMID:33647349 | lidocaine | increases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Lidocaine results in increased expression of PLEKHA2 mRNA | CTD | PMID:35283115 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | decreases expression | EXP | | 6480464 | Lipopolysaccharides results in decreased expression of PLEKHA2 mRNA | CTD | PMID:35811015 | melphalan | decreases expression | EXP | | 6480464 | Melphalan results in decreased expression of PLEKHA2 mRNA | CTD | PMID:22363485 | mercury dibromide | increases expression | EXP | | 6480464 | mercuric bromide results in increased expression of PLEKHA2 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | methyl methanesulfonate | decreases expression | EXP | | 6480464 | Methyl Methanesulfonate results in decreased expression of PLEKHA2 mRNA | CTD | PMID:23649840 | niclosamide | increases expression | EXP | | 6480464 | Niclosamide results in increased expression of PLEKHA2 mRNA | CTD | PMID:36318118 | panobinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | ISO | Plekha2 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of PLEKHA2 mRNA | CTD | PMID:33387578 | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of PLEKHA2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PLEKHA2 mRNA | CTD | PMID:17426115 | potassium chromate | decreases expression | EXP | | 6480464 | potassium chromate(VI) results in decreased expression of PLEKHA2 mRNA | CTD | PMID:22714537 | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of PLEKHA2 protein | CTD | PMID:23718831 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of PLEKHA2 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of PLEKHA2 mRNA | CTD | PMID:30851411 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | EXP | | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium fluoride | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of PLEKHA2 mRNA | CTD | PMID:27862939 | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of PLEKHA2 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | ISO | Plekha2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PLEKHA2 mRNA | CTD | PMID:17555576 | testosterone | increases expression | ISO | Plekha2 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of PLEKHA2 mRNA | CTD | PMID:33848595 | tetrachloromethane | affects expression | ISO | Plekha2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PLEKHA2 mRNA | CTD | PMID:17484886 | thimerosal | decreases expression | EXP | | 6480464 | Thimerosal results in decreased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | torcetrapib | increases expression | EXP | | 6480464 | torcetrapib results in increased expression of PLEKHA2 mRNA | CTD | PMID:23228038 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of PLEKHA2 mRNA | CTD | PMID:24935251 | triptonide | decreases expression | ISO | Plekha2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PLEKHA2 mRNA | CTD | PMID:33045310 | urethane | decreases expression | EXP | | 6480464 | Urethane results in decreased expression of PLEKHA2 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of PLEKHA2 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | vincristine | decreases expression | EXP | | 6480464 | Vincristine results in decreased expression of PLEKHA2 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | EXP | | 6480464 | vorinostat results in decreased expression of PLEKHA2 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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Molecular Pathway Annotations Click to see Annotation Detail View
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Phenotype Annotations
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. | Dowler S, etal., Biochem J 2000 Oct 1;351(Pt 1):19-31. |
| 2. | GOAs Human GO annotations | GOA_HUMAN data from the GO Consortium |
| 3. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 4. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:11802782 | PMID:14516276 | PMID:14702039 | PMID:16421571 | PMID:18029348 | PMID:19786618 | PMID:20379614 | PMID:21873635 | PMID:23460911 | PMID:25468996 | PMID:26760575 | PMID:27609421 |
| PMID:28611215 | PMID:29117863 | PMID:29467281 | PMID:30397336 | PMID:32296183 | PMID:32513696 | PMID:33545068 | PMID:33961781 | PMID:34315543 | PMID:35271311 | PMID:36215168 | PMID:36931259 |
| PMID:37689310 |
Genomics
Comparative Map Data
| PLEKHA2 (Homo sapiens - human) |
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| Plekha2 (Mus musculus - house mouse) |
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| Plekha2 (Rattus norvegicus - Norway rat) |
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| Plekha2 (Chinchilla lanigera - long-tailed chinchilla) |
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| PLEKHA2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PLEKHA2 (Canis lupus familiaris - dog) |
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| Plekha2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PLEKHA2 (Sus scrofa - pig) |
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| PLEKHA2 (Chlorocebus sabaeus - green monkey) |
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| Plekha2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in PLEKHA2
18 total Variants 
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