IFNW1 (interferon omega 1) - Rat Genome Database

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Gene: IFNW1 (interferon omega 1) Homo sapiens
Analyze
Symbol: IFNW1
Name: interferon omega 1
RGD ID: 1350481
HGNC Page HGNC:5448
Description: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: IFN-omega 1, interferon omega-1; interferon alpha-II-1; interferon omega-1; interferon, omega 1
RGD Orthologs
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Related Pseudogenes: IFNWP15   IFNWP18   IFNWP19   IFNWP2   IFNWP4   IFNWP5   IFNWP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,140,632 - 21,141,832 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl921,140,632 - 21,141,832 (-)EnsemblGRCh38hg38GRCh38
GRCh37921,140,631 - 21,141,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,130,631 - 21,132,144 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,130,630 - 21,132,144NCBI
Celera921,078,911 - 21,080,424 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,103,789 - 21,105,302 (-)NCBIHuRef
CHM1_1921,140,436 - 21,141,949 (-)NCBICHM1_1
T2T-CHM13v2.0921,154,492 - 21,155,692 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1385305   PMID:1647209   PMID:1693148   PMID:1834641   PMID:2985969   PMID:3895159   PMID:7913356   PMID:10835682   PMID:12089333   PMID:12477932   PMID:15340161   PMID:15489334  
PMID:15621727   PMID:16504056   PMID:19863576   PMID:20237496   PMID:20331378   PMID:20574843   PMID:20588308   PMID:20677014   PMID:21832049   PMID:21854986   PMID:21873635   PMID:22192711  
PMID:28514442   PMID:28957693   PMID:30936491   PMID:33961781   PMID:36233301   PMID:37759746  


Genomics

Comparative Map Data
IFNW1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,140,632 - 21,141,832 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl921,140,632 - 21,141,832 (-)EnsemblGRCh38hg38GRCh38
GRCh37921,140,631 - 21,141,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,130,631 - 21,132,144 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,130,630 - 21,132,144NCBI
Celera921,078,911 - 21,080,424 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,103,789 - 21,105,302 (-)NCBIHuRef
CHM1_1921,140,436 - 21,141,949 (-)NCBICHM1_1
T2T-CHM13v2.0921,154,492 - 21,155,692 (-)NCBIT2T-CHM13v2.0
Gm13271
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39488,673,105 - 88,673,653 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl488,673,105 - 88,673,653 (+)EnsemblGRCm39 Ensembl
GRCm38488,754,868 - 88,755,416 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl488,754,868 - 88,755,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37488,400,772 - 88,401,320 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36488,226,099 - 88,226,647 (+)NCBIMGSCv36mm8
Celera487,265,377 - 87,265,925 (+)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.03NCBI
LOC100996206
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,403,727 - 103,407,229 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,409,608 - 103,413,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,948,943 - 20,950,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,604,387 - 21,605,643 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl921,604,716 - 21,605,318 (-)Ensemblpanpan1.1panPan2
LOC100686162
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11140,697,253 - 40,697,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,362,763 - 39,363,305 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01141,642,248 - 41,642,790 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11140,334,315 - 40,334,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,122,937 - 40,123,479 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01140,758,117 - 40,758,659 (-)NCBIUU_Cfam_GSD_1.0
IFN-OMEGA-7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1201,316,989 - 201,317,561 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11201,316,989 - 201,317,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,853,285 - 224,853,857 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in IFNW1
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-13.1(chr9:204193-38815478)x3 copy number gain See cases [RCV000050357] Chr9:204193..38815478 [GRCh38]
Chr9:204193..38815475 [GRCh37]
Chr9:194193..38805475 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p21.3(chr9:21082471-23839529)x1 copy number loss See cases [RCV000052902] Chr9:21082471..23839529 [GRCh38]
Chr9:21082470..23839527 [GRCh37]
Chr9:21072470..23829527 [NCBI36]
Chr9:9p21.3		 pathogenic
GRCh38/hg38 9p24.3-21.3(chr9:204193-22086858)x3 copy number gain See cases [RCV000053704] Chr9:204193..22086858 [GRCh38]
Chr9:204193..22086857 [GRCh37]
Chr9:194193..22076857 [NCBI36]
Chr9:9p24.3-21.3		 pathogenic
GRCh38/hg38 9p24.3-13.3(chr9:204193-34599437)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053706]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053706]|See cases [RCV000053706] Chr9:204193..34599437 [GRCh38]
Chr9:204193..34599435 [GRCh37]
Chr9:194193..34589435 [NCBI36]
Chr9:9p24.3-13.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:220253-38815419)x3 copy number gain See cases [RCV000053747] Chr9:220253..38815419 [GRCh38]
Chr9:220253..38815416 [GRCh37]
Chr9:210253..38805416 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p23-21.1(chr9:9543538-30266463)x3 copy number gain See cases [RCV000053749] Chr9:9543538..30266463 [GRCh38]
Chr9:9543538..30266461 [GRCh37]
Chr9:9533538..30256461 [NCBI36]
Chr9:9p23-21.1		 pathogenic
GRCh38/hg38 9p23-13.3(chr9:13526091-34261642)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053750]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053750]|See cases [RCV000053750] Chr9:13526091..34261642 [GRCh38]
Chr9:13526090..34261640 [GRCh37]
Chr9:13516090..34251640 [NCBI36]
Chr9:9p23-13.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q21.11(chr9:13997-68401065)x3 copy number gain See cases [RCV000135344] Chr9:13997..68401065 [GRCh38]
Chr9:13997..71015981 [GRCh37]
Chr9:3997..70205801 [NCBI36]
Chr9:9p24.3-q21.11		 pathogenic
GRCh38/hg38 9p24.1-21.2(chr9:4661872-27661572)x3 copy number gain See cases [RCV000136680] Chr9:4661872..27661572 [GRCh38]
Chr9:4661872..27661570 [GRCh37]
Chr9:4651872..27651570 [NCBI36]
Chr9:9p24.1-21.2		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:204193-38741440)x3 copy number gain See cases [RCV000051106] Chr9:204193..38741440 [GRCh38]
Chr9:204193..38741437 [GRCh37]
Chr9:194193..38731437 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:203993-38815619)x3 copy number gain See cases [RCV000053703] Chr9:203993..38815619 [GRCh38]
Chr9:203993..38815616 [GRCh37]
Chr9:193993..38805616 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-13.3(chr9:204193-33284638)x3 copy number gain See cases [RCV000053707] Chr9:204193..33284638 [GRCh38]
Chr9:204193..33284636 [GRCh37]
Chr9:194193..33274636 [NCBI36]
Chr9:9p24.3-13.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-21.1(chr9:220257-29424848)x3 copy number gain See cases [RCV000134037] Chr9:220257..29424848 [GRCh38]
Chr9:220257..29424846 [GRCh37]
Chr9:210257..29414846 [NCBI36]
Chr9:9p24.3-21.1		 pathogenic
GRCh38/hg38 9p24.3-q21.12(chr9:193412-70630731)x3 copy number gain See cases [RCV000136152] Chr9:193412..70630731 [GRCh38]
Chr9:220253..73245647 [GRCh37]
Chr9:210253..72435467 [NCBI36]
Chr9:9p24.3-q21.12		 pathogenic
GRCh38/hg38 9p24.3-q21.13(chr9:193412-74615913)x3 copy number gain See cases [RCV000135954] Chr9:193412..74615913 [GRCh38]
Chr9:204193..77230829 [GRCh37]
Chr9:194193..76420649 [NCBI36]
Chr9:9p24.3-q21.13		 pathogenic
GRCh38/hg38 9p24.3-q21.11(chr9:204104-66233120)x4 copy number gain See cases [RCV000137888] Chr9:204104..66233120 [GRCh38]
Chr9:204104..47212321 [GRCh37]
Chr9:194104..47002141 [NCBI36]
Chr9:9p24.3-q21.11		 pathogenic|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-21.3(chr9:459131-24207894)x3 copy number gain See cases [RCV000138499] Chr9:459131..24207894 [GRCh38]
Chr9:459131..24207892 [GRCh37]
Chr9:449131..24197892 [NCBI36]
Chr9:9p24.3-21.3		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:204104-38768294)x3 copy number gain See cases [RCV000139126] Chr9:204104..38768294 [GRCh38]
Chr9:204104..38768291 [GRCh37]
Chr9:194104..38758291 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9p22.2-q21.11(chr9:18344605-68257015) copy number gain See cases [RCV000140448] Chr9:18344605..68257015 [GRCh38]
Chr9:18344603..68995221 [GRCh37]
Chr9:18334603..68285041 [NCBI36]
Chr9:9p22.2-q21.11		 pathogenic
GRCh38/hg38 9p21.3(chr9:20687770-21309178)x1 copy number loss See cases [RCV000137295] Chr9:20687770..21309178 [GRCh38]
Chr9:20687769..21309177 [GRCh37]
Chr9:20677769..21299177 [NCBI36]
Chr9:9p21.3		 uncertain significance
GRCh38/hg38 9p24.1-13.2(chr9:7162304-37038771)x3 copy number gain See cases [RCV000137741] Chr9:7162304..37038771 [GRCh38]
Chr9:7162304..37038768 [GRCh37]
Chr9:7152304..37028768 [NCBI36]
Chr9:9p24.1-13.2		 pathogenic
GRCh38/hg38 9p24.3-q21.11(chr9:204104-67549861)x3 copy number gain See cases [RCV000139208] Chr9:204104..67549861 [GRCh38]
Chr9:204104..66516698 [GRCh37]
Chr9:194104..66256518 [NCBI36]
Chr9:9p24.3-q21.11		 pathogenic
GRCh38/hg38 9p24.3-13.3(chr9:204104-34151476)x3 copy number gain See cases [RCV000139015] Chr9:204104..34151476 [GRCh38]
Chr9:204104..34151474 [GRCh37]
Chr9:194104..34141474 [NCBI36]
Chr9:9p24.3-13.3		 pathogenic|likely benign
GRCh38/hg38 9p22.1-21.1(chr9:19564275-28106622)x1 copy number loss See cases [RCV000139905] Chr9:19564275..28106622 [GRCh38]
Chr9:19564273..28106620 [GRCh37]
Chr9:19554273..28096620 [NCBI36]
Chr9:9p22.1-21.1		 pathogenic
GRCh38/hg38 9p24.3-21.2(chr9:204104-27963369)x3 copy number gain See cases [RCV000139621] Chr9:204104..27963369 [GRCh38]
Chr9:204104..27963367 [GRCh37]
Chr9:194104..27953367 [NCBI36]
Chr9:9p24.3-21.2		 pathogenic
GRCh38/hg38 9p24.3-q22.1(chr9:203861-88130444)x4 copy number gain See cases [RCV000141904] Chr9:203861..88130444 [GRCh38]
Chr9:203861..90745359 [GRCh37]
Chr9:193861..89935179 [NCBI36]
Chr9:9p24.3-q22.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:203861-38381642) copy number gain See cases [RCV000143411] Chr9:203861..38381642 [GRCh38]
Chr9:203861..38381639 [GRCh37]
Chr9:193861..38371639 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-13.1(chr9:204193-38815478)x3 copy number gain See cases [RCV000148159] Chr9:204193..38815478 [GRCh38]
Chr9:204193..38815475 [GRCh37]
Chr9:194193..38805475 [NCBI36]
Chr9:9p24.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:163131-38763958)x3 copy number gain See cases [RCV000240201] Chr9:163131..38763958 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-11.2(chr9:213161-47212321)x4 copy number gain See cases [RCV000240048] Chr9:213161..47212321 [GRCh37]
Chr9:9p24.3-11.2		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:213161-39092820)x3 copy number gain See cases [RCV000239869] Chr9:213161..39092820 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-67983174)x4 copy number gain See cases [RCV000446521] Chr9:203861..67983174 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p21.3(chr9:20951885-22447709)x1 copy number loss See cases [RCV000448195] Chr9:20951885..22447709 [GRCh37]
Chr9:9p21.3		 pathogenic
GRCh37/hg19 9p22.2-21.1(chr9:17684434-30889762)x3 copy number gain See cases [RCV000510665] Chr9:17684434..30889762 [GRCh37]
Chr9:9p22.2-21.1		 pathogenic
GRCh37/hg19 9p24.1-21.1(chr9:5900425-30008330)x3 copy number gain See cases [RCV000510425] Chr9:5900425..30008330 [GRCh37]
Chr9:9p24.1-21.1		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:203861-38787480)x3 copy number gain See cases [RCV000510864] Chr9:203861..38787480 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p22.2-13.3(chr9:17132123-35567051)x3 copy number gain See cases [RCV000510986] Chr9:17132123..35567051 [GRCh37]
Chr9:9p22.2-13.3		 pathogenic
GRCh37/hg19 9p23-21.2(chr9:10320113-26205565)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626433] Chr9:10320113..26205565 [GRCh37]
Chr9:9p23-21.2		 drug response
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-11.2(chr9:204193-44259464)x4 copy number gain Syndromic hydrocephalus due to diffuse villous hyperplasia of choroid plexus [RCV000677299] Chr9:204193..44259464 [GRCh37]
Chr9:9p24.3-11.2		 likely pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:203861-38787480)x3 copy number gain not provided [RCV000683172] Chr9:203861..38787480 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-21.2(chr9:203861-26397133)x3 copy number gain not provided [RCV000683171] Chr9:203861..26397133 [GRCh37]
Chr9:9p24.3-21.2		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-68262804)x3,4 copy number gain not provided [RCV000683174] Chr9:203861..68262804 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:214309-39156958) copy number gain not provided [RCV000767644] Chr9:214309..39156958 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p21.3(chr9:20715401-22136489) copy number loss not provided [RCV000767562] Chr9:20715401..22136489 [GRCh37]
Chr9:9p21.3		 pathogenic
GRCh37/hg19 9p24.3-q21.11(chr9:203861-70984588)x3 copy number gain not provided [RCV001006167] Chr9:203861..70984588 [GRCh37]
Chr9:9p24.3-q21.11		 pathogenic
GRCh37/hg19 9p21.3(chr9:21006599-21161950)x3 copy number gain not provided [RCV000848270] Chr9:21006599..21161950 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh37/hg19 9p21.3(chr9:20684175-21308693)x1 copy number loss not provided [RCV000847176] Chr9:20684175..21308693 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh37/hg19 9p21.3(chr9:20829681-22069144)x3 copy number gain not provided [RCV001006222] Chr9:20829681..22069144 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh37/hg19 9p24.3-q13(chr9:203861-67986965)x3 copy number gain not provided [RCV000845815] Chr9:203861..67986965 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p21.3(chr9:21041507-21285666)x1 copy number loss not provided [RCV001006224] Chr9:21041507..21285666 [GRCh37]
Chr9:9p21.3		 uncertain significance
NC_000009.11:g.12246100_101559378inv inversion Recurrent spontaneous abortion [RCV000999471] Chr9:12246100..101559378 [GRCh37]
Chr9:9p23-q22.33		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q21.32(chr9:203861-84155399) copy number gain not specified [RCV002053820] Chr9:203861..84155399 [GRCh37]
Chr9:9p24.3-q21.32		 pathogenic
GRCh37/hg19 9p24.3-13.3(chr9:203861-35903398)x3 copy number gain MISSED ABORTION [RCV002282974] Chr9:203861..35903398 [GRCh37]
Chr9:9p24.3-13.3		 pathogenic
GRCh37/hg19 9p21.3(chr9:20659492-22347440)x3 copy number gain not provided [RCV002473498] Chr9:20659492..22347440 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.230T>C (p.Met77Thr) single nucleotide variant not specified [RCV004129076] Chr9:21141341 [GRCh38]
Chr9:21141340 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.34G>T (p.Val12Leu) single nucleotide variant not specified [RCV004121544] Chr9:21141537 [GRCh38]
Chr9:21141536 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.418G>C (p.Ala140Pro) single nucleotide variant not specified [RCV004227305] Chr9:21141153 [GRCh38]
Chr9:21141152 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.118C>G (p.Leu40Val) single nucleotide variant not specified [RCV004221065] Chr9:21141453 [GRCh38]
Chr9:21141452 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.485G>A (p.Cys162Tyr) single nucleotide variant not specified [RCV004221126] Chr9:21141086 [GRCh38]
Chr9:21141085 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.568A>G (p.Arg190Gly) single nucleotide variant not specified [RCV004274808] Chr9:21141003 [GRCh38]
Chr9:21141002 [GRCh37]
Chr9:9p21.3		 likely benign
GRCh37/hg19 9p21.3(chr9:20663642-21312153)x4 copy number gain not provided [RCV003485354] Chr9:20663642..21312153 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh37/hg19 9p24.3-13.1(chr9:1475882-38771831)x3 copy number gain not provided [RCV003484765] Chr9:1475882..38771831 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
NM_002177.3(IFNW1):c.532T>C (p.Ser178Pro) single nucleotide variant not specified [RCV004400228] Chr9:21141039 [GRCh38]
Chr9:21141038 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.419C>T (p.Ala140Val) single nucleotide variant not specified [RCV004400226] Chr9:21141152 [GRCh38]
Chr9:21141151 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh38/hg38 9p24.3-21.1(chr9:203861-31423873)x4 copy number gain See cases [RCV000141662] Chr9:203861..31423873 [GRCh38]
Chr9:203861..31423871 [GRCh37]
Chr9:193861..31413871 [NCBI36]
Chr9:9p24.3-21.1		 pathogenic
GRCh38/hg38 9p24.3-q21.31(chr9:193412-79877816)x3 copy number gain See cases [RCV000143012] Chr9:193412..79877816 [GRCh38]
Chr9:204104..82492731 [GRCh37]
Chr9:194104..81682551 [NCBI36]
Chr9:9p24.3-q21.31		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-68188391)x4 copy number gain See cases [RCV000449165] Chr9:203861..68188391 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:32396-39140211) copy number gain See cases [RCV000447246] Chr9:32396..39140211 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-q21.11(chr9:13997-70919878)x4 copy number gain See cases [RCV000448242] Chr9:13997..70919878 [GRCh37]
Chr9:9p24.3-q21.11		 pathogenic
GRCh37/hg19 9p24.3-q21.11(chr9:203861-69002883)x3 copy number gain See cases [RCV000448569] Chr9:203861..69002883 [GRCh37]
Chr9:9p24.3-q21.11		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p21.3(chr9:20684175-21312153)x1 copy number loss See cases [RCV000511958] Chr9:20684175..21312153 [GRCh37]
Chr9:9p21.3		 uncertain significance
GRCh37/hg19 9p24.3-q21.33(chr9:203861-88189913)x3 copy number gain See cases [RCV000512431] Chr9:203861..88189913 [GRCh37]
Chr9:9p24.3-q21.33		 pathogenic
GRCh37/hg19 9p24.3-q21.11(chr9:203861-70985795)x4 copy number gain not provided [RCV000683175] Chr9:203861..70985795 [GRCh37]
Chr9:9p24.3-q21.11		 pathogenic
GRCh37/hg19 9p24.3-q21.12(chr9:203861-72717793)x3 copy number gain not provided [RCV000683176] Chr9:203861..72717793 [GRCh37]
Chr9:9p24.3-q21.12		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-67983174)x4 copy number gain not provided [RCV000683173] Chr9:203861..67983174 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
Single allele duplication Schizophrenia [RCV000754362] Chr9:20655425..24580688 [GRCh38]
Chr9:9p21.3		 likely pathogenic
GRCh37/hg19 9p21.3(chr9:20834837-22101120)x1 copy number loss not provided [RCV000748288] Chr9:20834837..22101120 [GRCh37]
Chr9:9p21.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-21.3(chr9:46587-22012051)x3 copy number gain not provided [RCV000748062] Chr9:46587..22012051 [GRCh37]
Chr9:9p24.3-21.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.2-21.3(chr9:4420767-22195820)x3 copy number gain not provided [RCV000748122] Chr9:4420767..22195820 [GRCh37]
Chr9:9p24.2-21.3		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:203861-38472979)x3 copy number gain not provided [RCV000848175] Chr9:203861..38472979 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-67986965) copy number gain Tetrasomy 9p [RCV002280656] Chr9:203861..67986965 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p24.3-q13(chr9:203861-68342786) copy number gain Bradycardia [RCV002280662] Chr9:203861..68342786 [GRCh37]
Chr9:9p24.3-q13		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:203861-38787480) copy number gain not specified [RCV002053818] Chr9:203861..38787480 [GRCh37]
Chr9:9p24.3-13.1		 pathogenic
GRCh37/hg19 9p24.3-13.3(chr9:676264-33743670) copy number gain not specified [RCV002053827] Chr9:676264..33743670 [GRCh37]
Chr9:9p24.3-13.3		 pathogenic
GRCh37/hg19 9p24.3-q21.11(chr9:203861-69002883) copy number gain not specified [RCV002053819] Chr9:203861..69002883 [GRCh37]
Chr9:9p24.3-q21.11		 pathogenic
GRCh37/hg19 9p24.3-13.1(chr9:48827-39154913)x3 copy number gain Syndromic anorectal malformation [RCV002286608] Chr9:48827..39154913 [GRCh37]
Chr9:9p24.3-13.1		 likely pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
NM_002177.3(IFNW1):c.194T>C (p.Met65Thr) single nucleotide variant not specified [RCV004211140] Chr9:21141377 [GRCh38]
Chr9:21141376 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.479G>C (p.Ser160Thr) single nucleotide variant not specified [RCV004357517] Chr9:21141092 [GRCh38]
Chr9:21141091 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.301A>G (p.Asn101Asp) single nucleotide variant not specified [RCV004400224] Chr9:21141270 [GRCh38]
Chr9:21141269 [GRCh37]
Chr9:9p21.3		 uncertain significance
NM_002177.3(IFNW1):c.410G>A (p.Ser137Asn) single nucleotide variant not specified [RCV004400225] Chr9:21141161 [GRCh38]
Chr9:21141160 [GRCh37]
Chr9:9p21.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:105
Interacting mature miRNAs:106
Transcripts:ENST00000380229
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D9S1967  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37921,140,669 - 21,140,981UniSTSGRCh37
Build 36921,130,669 - 21,130,981RGDNCBI36
Celera921,078,949 - 21,079,261RGD
Cytogenetic Map9p22UniSTS
HuRef921,103,827 - 21,104,139UniSTS
Whitehead-YAC Contig Map9 UniSTS
IFNW1_147  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37921,140,549 - 21,141,432UniSTSGRCh37
Build 36921,130,549 - 21,131,432RGDNCBI36
Celera921,078,829 - 21,079,712RGD
HuRef921,103,707 - 21,104,590UniSTS
UniSTS:482401  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37921,140,941 - 21,141,608UniSTSGRCh37
Celera921,079,221 - 21,079,888UniSTS
HuRef921,104,099 - 21,104,766UniSTS
UniSTS:491186  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37921,140,807 - 21,141,606UniSTSGRCh37
Celera921,079,087 - 21,079,886UniSTS
HuRef921,103,965 - 21,104,764UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 3
Low 31 6 1 18 1
Below cutoff 825 780 603 78 515 38 857 602 2465 76 643 539 42 288 611

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A12140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI860608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY780805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ847553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM863571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH960130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U25670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000380229   ⟹   ENSP00000369578
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl921,140,632 - 21,141,832 (-)Ensembl
RefSeq Acc Id: NM_002177   ⟹   NP_002168
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38921,140,632 - 21,141,832 (-)NCBI
GRCh37921,140,631 - 21,142,144 (-)ENTREZGENE
Build 36921,130,631 - 21,132,144 (-)NCBI Archive
HuRef921,103,789 - 21,105,302 (-)ENTREZGENE
CHM1_1921,140,436 - 21,141,705 (-)NCBI
T2T-CHM13v2.0921,154,492 - 21,155,692 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002168   ⟸   NM_002177
- Peptide Label: precursor
- UniProtKB: Q5VWD0 (UniProtKB/Swiss-Prot),   Q5U802 (UniProtKB/Swiss-Prot),   Q13168 (UniProtKB/Swiss-Prot),   Q7M4P5 (UniProtKB/Swiss-Prot),   P05000 (UniProtKB/Swiss-Prot),   A0A7R8GUW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000369578   ⟸   ENST00000380229

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05000-F1-model_v2 AlphaFold P05000 1-195 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5448 AgrOrtholog
COSMIC IFNW1 COSMIC
Ensembl Genes ENSG00000177047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000380229 ENTREZGENE
  ENST00000380229.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000177047 GTEx
HGNC ID HGNC:5448 ENTREZGENE
Human Proteome Map IFNW1 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_alpha/beta/delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3467 ENTREZGENE
OMIM 147553 OMIM
PANTHER INTERFERON OMEGA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11691 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Interferon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29683 PharmGKB
PRINTS INTERFERONAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERFERON_A_B_D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IFabd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7R8GUW6 ENTREZGENE, UniProtKB/TrEMBL
  IFNW1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q13168 ENTREZGENE
  Q5U802 ENTREZGENE
  Q5VWD0 ENTREZGENE
  Q7M4P5 ENTREZGENE
UniProt Secondary Q13168 UniProtKB/Swiss-Prot
  Q5U802 UniProtKB/Swiss-Prot
  Q5VWD0 UniProtKB/Swiss-Prot
  Q7M4P5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 IFNW1  interferon omega 1    interferon, omega 1  Symbol and/or name change 5135510 APPROVED