MIR135A2 (microRNA 135a-2) - Rat Genome Database

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Gene: MIR135A2 (microRNA 135a-2) Homo sapiens
Analyze
Symbol: MIR135A2
Name: microRNA 135a-2
RGD ID: 1348256
HGNC Page HGNC:31521
Description: Enables lncRNA binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; cellular response to oxidative stress; and miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-135a-2; MIRN135-2; MIRN135A2
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381297,563,812 - 97,563,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1297,563,812 - 97,563,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371297,957,590 - 97,957,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361296,481,720 - 96,481,819 (+)NCBINCBI36Build 36hg18NCBI36
Celera1297,623,232 - 97,623,331 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1295,019,998 - 95,020,097 (+)NCBIHuRef
CHM1_11297,922,584 - 97,922,683 (+)NCBICHM1_1
T2T-CHM13v2.01297,536,995 - 97,537,094 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Neuralgia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:12624257   PMID:15183728   PMID:16381832   PMID:17604727   PMID:21037258   PMID:22747683   PMID:24908566   PMID:25013381   PMID:25142144   PMID:25152461   PMID:25322930  
PMID:25634212   PMID:25888950   PMID:26134897   PMID:26261511   PMID:27302923   PMID:27525941   PMID:28100188   PMID:28159835   PMID:29268774   PMID:29295721   PMID:29331391   PMID:30006972  
PMID:30024610   PMID:30778058   PMID:30993701   PMID:31173821   PMID:31545249   PMID:32222724   PMID:32415843   PMID:32560824   PMID:34036386   PMID:34110633   PMID:34378214   PMID:34537058  
PMID:34667160   PMID:35124585   PMID:35818205   PMID:36009038   PMID:36538242   PMID:36869643   PMID:37667545  


Genomics

Comparative Map Data
MIR135A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381297,563,812 - 97,563,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1297,563,812 - 97,563,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371297,957,590 - 97,957,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361296,481,720 - 96,481,819 (+)NCBINCBI36Build 36hg18NCBI36
Celera1297,623,232 - 97,623,331 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1295,019,998 - 95,020,097 (+)NCBIHuRef
CHM1_11297,922,584 - 97,922,683 (+)NCBICHM1_1
T2T-CHM13v2.01297,536,995 - 97,537,094 (+)NCBIT2T-CHM13v2.0
Mir135a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391091,907,948 - 91,908,047 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1091,907,948 - 91,908,047 (-)EnsemblGRCm39 Ensembl
GRCm381092,072,086 - 92,072,185 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1092,072,086 - 92,072,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv371091,534,831 - 91,534,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1094,057,667 - 94,057,766 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1046.67NCBI
Mir135a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8728,499,166 - 28,499,265 (-)NCBIGRCr8
mRatBN7.2726,611,990 - 26,612,089 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl726,611,990 - 26,612,089 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx728,606,371 - 28,606,470 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0730,768,735 - 30,768,834 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0730,546,724 - 30,546,823 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0732,894,877 - 32,894,976 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl732,894,877 - 32,894,976 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0732,974,076 - 32,974,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera723,729,864 - 23,729,963 (-)NCBICelera
Cytogenetic Map7q13NCBI
MIR135A-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11537,181,419 - 37,181,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1537,181,398 - 37,181,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1537,563,521 - 37,563,582 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01537,844,448 - 37,844,509 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1537,844,427 - 37,844,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,117,051 - 37,117,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01537,209,396 - 37,209,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01537,481,763 - 37,481,824 (+)NCBIUU_Cfam_GSD_1.0
MIR135-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl586,141,185 - 86,141,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1586,141,185 - 86,141,284 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2590,552,047 - 90,552,146 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.1-23.2(chr12:97394550-101410225)x3 copy number gain See cases [RCV000137891] Chr12:97394550..101410225 [GRCh38]
Chr12:97788328..101804003 [GRCh37]
Chr12:96312459..100328134 [NCBI36]
Chr12:12q23.1-23.2		 likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11		 pathogenic
GRCh38/hg38 12q23.1(chr12:97452763-98257706)x3 copy number gain See cases [RCV000142277] Chr12:97452763..98257706 [GRCh38]
Chr12:97846541..98651484 [GRCh37]
Chr12:96370672..97175615 [NCBI36]
Chr12:12q23.1		 uncertain significance
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
JAK2hsa-miR-135a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19666866
NR3C2hsa-miR-135a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19944075
MYChsa-miR-135a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23176581
PTK2hsa-miR-135a-5pOncomiRDBexternal_infoNANA23438844
MYChsa-miR-135a-5pOncomiRDBexternal_infoNANA23176581
MTSS1hsa-miR-135a-5pOncomiRDBexternal_infoNANA23017832
HOXA10hsa-miR-135a-5pOncomiRDBexternal_infoNANA22439757
JAK2hsa-miR-135a-5pOncomiRDBexternal_infoNANA22310976
STAT6hsa-miR-135a-5pOncomiRDBexternal_infoNANA22139076
MTSS1hsa-miR-135a-5pOncomiRDBexternal_infoNANA21888875
APChsa-miR-135a-5pOncomiRDBexternal_infoNANA21552288
JAK2hsa-miR-135a-5pOncomiRDBexternal_infoNANA19666866
APChsa-miR-135a-5pOncomiRDBexternal_infoNANA18632633

Predicted Targets
Summary Value
Count of predictions:21409
Count of gene targets:8622
Count of transcripts:16379
Interacting mature miRNAs:hsa-miR-135a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 35 2 2 2 30 47
Low 9 1 54 37 13 37 2 28 79 67 41
Below cutoff 2 9 6 4 6 1 2 6 13 7 10

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1297,563,812 - 97,563,911 (+)Ensembl
RefSeq Acc Id: NR_029678
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381297,563,812 - 97,563,911 (+)NCBI
GRCh371297,957,590 - 97,957,689 (+)RGD
Celera1297,623,232 - 97,623,331 (+)RGD
HuRef1295,019,998 - 95,020,097 (+)ENTREZGENE
CHM1_11297,922,584 - 97,922,683 (+)NCBI
T2T-CHM13v2.01297,536,995 - 97,537,094 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31521 AgrOrtholog
COSMIC MIR135A2 COSMIC
Ensembl Genes ENSG00000207586 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384854 ENTREZGENE
GTEx ENSG00000207586 GTEx
HGNC ID HGNC:31521 ENTREZGENE
Human Proteome Map MIR135A2 Human Proteome Map
miRBase MI0000453 ENTREZGENE
NCBI Gene 406926 ENTREZGENE
PharmGKB PA164722482 PharmGKB
RNAcentral URS00000A7BEB RNACentral
  URS00000DF6D0 RNACentral
  URS000075AB6F RNACentral