Gene: Alox12 (arachidonate 12-lipoxygenase)
Mus musculus
Symbol:
Alox12
Name:
arachidonate 12-lipoxygenase
Description:
ENCODES a protein that exhibits arachidonate 12-lipoxygenase activity (ortholog); INVOLVED IN negative regulation of apoptotic process; positive regulation of cell proliferation; cellular component movement (ortholog); PARTICIPATES IN lipoxygenase mediated pathway of arachidonic acid metabolism; arachidonic acid metabolic pathway; ASSOCIATED WITH impaired skin barrier function; increased platelet aggregation; thrombosis; ASSOCIATED WITH Lung Neoplasms; Obesity; Albuminuria (ortholog); FOUND IN cytosol (ortholog); sarcolemma (ortholog); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
12S-lipoxygenase; 12S-LOX; 9930022G08Rik; Alox12p; arachidonate 12-lipoxygenase, 12S-type; OTTMUSP00000006289; P-12LO; platelet-type lipoxygenase 12
Orthologs:
Homo sapiens : ALOX12
(arachidonate 12-lipoxygenase)
HGNC
Rattus norvegicus : Alox12
(arachidonate 12-lipoxygenase)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 70,241,455 - 70,255,341 - NCBI Mouse cM Map 11 42.99 NCBI Mouse Celera Assembly 11 77,785,930 - 77,799,829 - NCBI Mouse Genome Assembly Build 37 11 70,054,957 - 70,068,843 - NCBI Mouse Genome Assembly Build 36.1 11 70,054,957 - 70,068,843 - NCBI Mouse Cytogenetic Map 11 B3 NCBI
Model
Gene-Chemical Interaction Annotations
(S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of ALOX12 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of ALOX12 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALOX12 mRNA CTD PMID:17942748 arachidonic acid increases metabolic processing ISO RGD:1322469 6480464 ALOX12 protein results in increased metabolism of Arachidonic Acid CTD PMID:17027136 arachidonic acid affects response to substance EXP 6480464 ALOX12 protein affects the susceptibility to Arachidonic Acid CTD PMID:19373248 baicalein multiple interactions ISO RGD:1322469 6480464 baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] CTD PMID:17027136 baicalein decreases activity ISO RGD:1322469 6480464 baicalein results in decreased activity of ALOX12 protein CTD PMID:17027136 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of ALOX12 mRNA CTD PMID:21715664 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of ALOX12 mRNA CTD PMID:15674844 calcitriol decreases expression ISO RGD:1322469 6480464 Calcitriol results in decreased expression of ALOX12 mRNA CTD PMID:16002434 carmustine affects response to substance EXP 6480464 ALOX12 protein affects the susceptibility to Carmustine CTD PMID:19373248 carmustine decreases expression ISO RGD:1311159 6480464 Carmustine results in decreased expression of ALOX12 mRNA CTD PMID:16005536 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of ALOX12 mRNA CTD PMID:15464296 D-penicillamine increases expression ISO RGD:1311159 6480464 Penicillamine results in increased expression of ALOX12 mRNA CTD PMID:19575532 D-penicillamine decreases expression ISO RGD:1311159 6480464 Penicillamine results in decreased expression of ALOX12 mRNA CTD PMID:19575532 diuron decreases expression ISO RGD:1311159 6480464 Diuron results in decreased expression of ALOX12 mRNA CTD PMID:21551480 fenofibrate increases expression ISO RGD:1322469 6480464 Fenofibrate results in increased expression of ALOX12 mRNA CTD PMID:12759900 glutathione disulfide affects response to substance EXP 6480464 ALOX12 protein affects the susceptibility to Glutathione Disulfide CTD PMID:19373248 glutathione disulfide increases glutathionylation EXP 6480464 Glutathione Disulfide results in increased glutathionylation of ALOX12 protein CTD PMID:19373248 glutathione disulfide increases activity EXP 6480464 Glutathione Disulfide results in increased activity of ALOX12 protein CTD PMID:19373248 indomethacin decreases activity ISO RGD:1311159 6480464 Indomethacin results in decreased activity of ALOX12 protein CTD PMID:3928952 kaempferol decreases activity ISO RGD:1322469 6480464 kaempferol results in decreased activity of ALOX12 protein CTD PMID:17027136 kaempferol multiple interactions ISO RGD:1322469 6480464 kaempferol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] CTD PMID:17027136 methotrexate decreases expression ISO RGD:1311159 6480464 Methotrexate results in decreased expression of ALOX12 mRNA CTD PMID:16005536 methotrexate decreases expression ISO RGD:1322469 6480464 Methotrexate results in decreased expression of ALOX12 mRNA CTD PMID:17400583 perfluorooctanoic acid multiple interactions EXP 6480464 [perfluorooctanoic acid co-treated with PPARA] results in increased expression of ALOX12 mRNA CTD PMID:20118188 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of ALOX12 mRNA CTD PMID:20813756 quercetin decreases activity ISO RGD:1322469 6480464 Quercetin results in decreased activity of ALOX12 protein CTD PMID:17027136 quercetin multiple interactions ISO RGD:1322469 6480464 Quercetin inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] CTD PMID:17027136 resveratrol decreases activity ISO RGD:1322469 6480464 resveratrol results in decreased activity of ALOX12 protein CTD PMID:17027136 resveratrol multiple interactions ISO RGD:1322469 6480464 resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] CTD PMID:17027136 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of ALOX12 mRNA CTD PMID:17555576 tioguanine decreases expression ISO RGD:1311159 6480464 Thioguanine results in decreased expression of ALOX12 mRNA CTD PMID:16005536 trans-resveratrol decreases activity ISO RGD:1322469 6480464 resveratrol results in decreased activity of ALOX12 protein CTD PMID:17027136 trans-resveratrol multiple interactions ISO RGD:1322469 6480464 resveratrol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] CTD PMID:17027136 trimellitic anhydride decreases expression EXP 6480464 trimellitic anhydride results in decreased expression of ALOX12 mRNA CTD PMID:19042947 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of ALOX12 mRNA CTD PMID:17963808
Biological Process
cellular component movement ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 fatty acid oxidation ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 leukotriene biosynthetic process IEA UniProtKB-KW:KW-0434 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 leukotriene metabolic process IEA InterPro:IPR001885 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 negative regulation of apoptotic process ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of apoptotic process ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of apoptotic process IMP 2290270 MGI:MGI:3696513|PMID:15161019 UniProtKB MGI:MGI:3696513 PMID:15161019 oxidation-reduction process IEA InterPro:IPR000907|InterPro:IPR013819|InterPro:IPR020834|InterPro:IPR020833|InterPro:IPR001885 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 oxidation-reduction process IEA UniProtKB-KW:KW-0560 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 positive regulation of apoptotic process ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of cell adhesion ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell death ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of cell growth ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell proliferation IMP 2290270 MGI:MGI:3696513|PMID:15161019 UniProtKB MGI:MGI:3696513 PMID:15161019 positive regulation of cell proliferation ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell proliferation ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of endothelial cell differentiation ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of endothelial cell migration ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of gene expression ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of mitochondrial depolarization ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of smooth muscle cell proliferation ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 positive regulation of vasodilation ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
Cellular Component
cytoplasm IEA UniProtKB-KW:KW-0963 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 cytosol ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 cytosol ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sarcolemma ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
arachidonate 12-lipoxygenase activity ISO NCBI:NP_001099268 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 arachidonate 12-lipoxygenase activity ISO UniProtKB:P18054 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 iron ion binding IEA InterPro:IPR001885 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 lipoxygenase activity IEA InterPro:IPR001885 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 metal ion binding IEA InterPro:IPR000907|InterPro:IPR013819|InterPro:IPR020834|InterPro:IPR020833 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 oxidoreductase activity IEA UniProtKB-KW:KW-0560 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA InterPro:IPR000907|InterPro:IPR013819|InterPro:IPR020834|InterPro:IPR020833 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA UniProtKB-KW:KW-0223 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
1302124 Eae7_m susceptibility to experimental allergic encephalomyelitis 7 (mouse) Not determined 11 69874328 103874451 Mouse 1357580 Pltct2_m platelet count 2 (mouse) Not determined 11 69874328 103874451 Mouse 1301161 Slthsr_m semilethal sex-restricted (mouse) Not determined 11 67654000 101654138 Mouse 4142316 Ity2b_m immunity to S. typhimurium 2b (mouse) Not determined 11 67000867 79736588 Mouse 1300628 Lgth6_m body length 6 (mouse) Not determined 11 66656096 100656328 Mouse 4142191 Lwq9_m liver weight QTL 9 (mouse) Not determined 11 66656096 100656328 Mouse 4141767 Kwq15_m kidney weight QTL 15 (mouse) Not determined 11 66656096 100656328 Mouse 4141264 Qbis3_m QTL for body weight independent of sex 3 (mouse) Not determined 11 66656096 100656328 Mouse 1301833 Tbbmd5_m total body bone mineral density 5 (mouse) Not determined 11 66656096 100656328 Mouse 1301546 Pcir2_m periosteal circumference 2 (mouse) Not determined 11 66656096 100656328 Mouse 1357766 Si5lq6_m serum IGFBP-5 level QTL 6 (mouse) Not determined 11 66656096 100656328 Mouse 1300784 Prdt3_m prion disease incubation time 3 (mouse) Not determined 11 66656096 100656328 Mouse 1301030 Bw4_m body weight QTL 4 (mouse) Not determined 11 66403911 100404032 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 66403911 100404032 Mouse 1301956 Orch3_m autoimmune orchitis resistance 3 (mouse) Not determined 11 62736435 96736588 Mouse 1301319 Dautb4_m dopamine uptake transporter binding 4 (mouse) Not determined 11 62078681 96078829 Mouse 4142202 Feml4_m femur length in high growth mice 4 (mouse) Not determined 11 59866991 93867100 Mouse 1301182 Vmbic6_m ventral midbrain iron content 6 (mouse) Not determined 11 59777286 93777433 Mouse 1301548 Idd4_m insulin dependent diabetes susceptibility 4 (mouse) Not determined 11 57677336 91677434 Mouse 4142121 Tmc1m2_m Tmc1 modifier 2 (mouse) Not determined 11 56786703 114128445 Mouse 4141830 Pregq1_m pregnancy QTL 1 (mouse) Not determined 11 54049428 83656328 Mouse 4141612 Cia40_m collagen induced arthritis 40 (mouse) Not determined 11 53988346 117993212 Mouse 1558896 Motp1_m modifier of Trp53 1 (mouse) Not determined 11 53313264 87313413 Mouse 1300774 Pgia7_m proteoglycan induced arthritis 7 (mouse) Not determined 11 53313264 87313413 Mouse 1301238 Pas5_m pulmonary adenoma susceptibility 5 (mouse) Not determined 11 52761978 86762125 Mouse 1302108 Skl5_m skeletal size (tail length) 5 (mouse) Not determined 11 52761978 86762125 Mouse 1301906 Bgeq9_m body growth early QTL 9 (mouse) Not determined 11 52761978 86762125 Mouse 1300744 Tshp10_m tooth shape 10 (mouse) Not determined 11 52761978 86762125 Mouse 4141085 Rbcq3_m red blood cell QTL 3 (mouse) Not determined 11 52607486 86607663 Mouse 1301842 Gvhd4_m graft-versus host disease 4 (mouse) Not determined 11 52101109 86101222 Mouse 1357794 Cinda1_m cytokine induced activation 1 (mouse) Not determined 11 51422759 85423006 Mouse 1357827 Hdl39_m HDL level 39 (mouse) Not determined 11 51422759 85423006 Mouse 4141825 Hdlq37_m HDL QTL 37 (mouse) Not determined 11 51422759 85423006 Mouse 1301830 Ssta4_m susceptibility to Salmonella typhimurium antigens 4 (mouse) Not determined 11 50000867 84001087 Mouse 1558963 Sphsr2_m spermatocyte heat stress resistance 2 (mouse) Not determined 11 50000867 84001087 Mouse 4141832 Vmmt12_m vertebral morphology and mechanical traits 12 (mouse) Not determined 11 46323910 80324021 Mouse 1301999 Lmr15_m leishmaniasis resistance 15 (mouse) Not determined 11 46242083 80242198 Mouse 1357782 Char8_m P. chabaudi malaria resistance QTL 8 (mouse) Not determined 11 46242083 80242198 Mouse 4142024 Azdm1_m Alzheimer's disease modifier 1 (mouse) Not determined 11 46242083 80242198 Mouse 1301988 Bmd11_m bone mineral density 11 (mouse) Not determined 11 46242083 80242198 Mouse 4141641 Fina1_m fat induced adiposity 1 (mouse) Not determined 11 46242083 80242198 Mouse 1301987 Pid3_m prior incubation determinant 3 (mouse) Not determined 11 44609496 78609590 Mouse 1558967 Scc15_m colon tumor susceptibility 15 (mouse) Not determined 11 43325202 77325392 Mouse 4142300 Ctrq3_m C. trachomatis resistance QTL 3 (mouse) Not determined 11 40728239 74728330 Mouse 1302021 Nidd1n_m non-insulin-dependent diabetes mellitus 1 in NSY (mouse) Not determined 11 39498226 73498375 Mouse 1357868 Manln11_m mandible length 11 (mouse) Not determined 11 38855553 72855725 Mouse 1559011 Pbmd4_m peak bone mineral density 4 (mouse) Not determined 11 38602850 72602967 Mouse 4141853 Skmw17_m skeletal muscle weight 17 (mouse) Not determined 11 37003617 71003740 Mouse 4142384 Hfem3_m Hfe modifier 3 (mouse) Not determined 11 37003617 71003740 Mouse 4141183 Elda1_m ethanol induced low dose activation 1 (mouse) Not determined 11 36988346 70988470 Mouse 1300569 Eae6b_m susceptibility to experimental allergic encephalomyelitis 6b (mouse) Not determined 11 36988346 70988470 Mouse 1301896 Tria1_m T-cell receptor induced activation 1 (mouse) Not determined 11 36536240 70536530 Mouse