ALOX12 (arachidonate 12-lipoxygenase, 12S type) - Rat Genome Database

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Pathways
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Gene: ALOX12 (arachidonate 12-lipoxygenase, 12S type) Homo sapiens
Analyze
Symbol: ALOX12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 1322469
HGNC Page HGNC:429
Description: Enables arachidonate 12(S)-lipoxygenase activity; arachidonate 15-lipoxygenase activity; and linoleate 13S-lipoxygenase activity. Involved in fatty acid metabolic process and negative regulation of muscle cell apoptotic process. Located in cytosol and sarcolemma. Biomarker of several diseases, including inflammatory bowel disease (multiple); prostate cancer; psoriasis; type 2 diabetes mellitus; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 12(S)-lipoxygenase; 12-LOX; 12S-lipoxygenase; 12S-LOX; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; LOG12; platelet 12-LOX; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ALOX12P1   ALOX12P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
aldehydo-D-glucose  (EXP)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP)
baicalein  (EXP)
benoxaprofen  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cerium trichloride  (EXP)
CGP 52608  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (EXP)
D-penicillamine  (ISO)
dextran sulfate  (ISO)
dioxygen  (EXP)
dithiol  (ISO)
diuron  (ISO)
docebenone  (ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
genistein  (ISO)
glucose  (EXP)
glutathione disulfide  (ISO)
hydroquinone  (EXP)
indometacin  (ISO)
kaempferol  (EXP)
Licochalcone B  (EXP)
lidocaine  (ISO)
masoprocol  (EXP,ISO)
methotrexate  (EXP,ISO)
nickel atom  (EXP)
nicotine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
picrotoxin  (ISO)
pirinixic acid  (ISO)
polymyxin B2  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (ISO)
tetraphene  (ISO)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (IBA,IDA,IEA,TAS)
extracellular exosome  (HDA)
membrane  (IDA,IEA)
sarcolemma  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Arachidonic acid cascade in endothelial pathobiology. Bogatcheva NV, etal., Microvasc Res. 2005 May;69(3):107-27.
2. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Chakrabarti SK, etal., Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
3. Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. Chen YQ, etal., Cancer Res. 1994 Mar 15;54(6):1574-9.
4. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer. Gao X, etal., Urology. 1995 Aug;46(2):227-37.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Hussain H, etal., Am J Physiol. 1994 Jan;266(1 Pt 1):C243-53.
7. Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats. Kong SW, etal., Physiol Genomics. 2005 Mar 21;21(1):34-42. Epub 2004 Dec 28.
8. An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. Kumar NN, etal., Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):71-5.
9. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Liu Y, etal., Am J Kidney Dis. 2008 Aug;52(2):242-50. Epub 2008 Mar 25.
10. The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury. Matsuyama M, etal., Transplant Proc. 2004 Sep;36(7):1939-42.
11. Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. Nie D, etal., Clin Exp Metastasis. 2003;20(7):657-63.
12. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Nunemaker CS, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. Epub 2008 Sep 9.
13. Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Pei H, etal., Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
18. Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease. Shannon VR, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):G104-11.
19. Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus. Tohjima T, etal., Metabolism. 1998 Mar;47(3):257-63.
20. Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. Xu ZG, etal., Nephrol Dial Transplant. 2009 Jun;24(6):1744-52. Epub 2008 Dec 22.
21. Arachidonate 12-lipoxygenases. Yoshimoto T and Takahashi Y, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:245-62.
22. Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. Yoshimura R, etal., Int J Mol Med. 2004 Jan;13(1):41-6.
23. Relationship between lipoxygenase and human testicular cancer. Yoshimura R, etal., Int J Mol Med. 2004 Mar;13(3):389-93.
24. Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. Yoshimura R, etal., J Urol. 2003 Nov;170(5):1994-9.
25. Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. Zeeneldin AA, etal., Indian J Cancer. 2009 Jan-Mar;46(1):54-60.
Additional References at PubMed
PMID:1447217   PMID:1570320   PMID:1851637   PMID:2217179   PMID:2244907   PMID:2377602   PMID:3406043   PMID:3926763   PMID:7868854   PMID:8250832   PMID:8319693   PMID:8641843  
PMID:8912711   PMID:9082968   PMID:9751607   PMID:10446449   PMID:10727209   PMID:10760478   PMID:11914583   PMID:12394183   PMID:12477932   PMID:12538614   PMID:12664313   PMID:12664573  
PMID:12664578   PMID:12731864   PMID:12858336   PMID:12907138   PMID:15010818   PMID:15105833   PMID:15107407   PMID:15111312   PMID:15142951   PMID:15305153   PMID:15308583   PMID:15474031  
PMID:15489334   PMID:15729574   PMID:15797645   PMID:16118214   PMID:16482570   PMID:16514435   PMID:16598376   PMID:16638750   PMID:16788089   PMID:17045234   PMID:17151091   PMID:17192687  
PMID:17236225   PMID:17379189   PMID:17460548   PMID:17493578   PMID:17520163   PMID:18086569   PMID:18155727   PMID:18187376   PMID:18311922   PMID:18504448   PMID:18547056   PMID:18676680  
PMID:18755188   PMID:18992148   PMID:19046748   PMID:19056867   PMID:19170196   PMID:19328558   PMID:19423540   PMID:19469483   PMID:19625176   PMID:19663136   PMID:19692168   PMID:19885615  
PMID:19913121   PMID:19948975   PMID:20061896   PMID:20089617   PMID:20181616   PMID:20382140   PMID:20406964   PMID:20431935   PMID:20438785   PMID:20453000   PMID:20570249   PMID:20592751  
PMID:20626912   PMID:20628086   PMID:20653566   PMID:20697415   PMID:21085606   PMID:21094135   PMID:21104233   PMID:21127289   PMID:21225230   PMID:21873635   PMID:21945939   PMID:22089472  
PMID:22237009   PMID:22275252   PMID:22323304   PMID:22384268   PMID:22668814   PMID:22825379   PMID:22864639   PMID:22895552   PMID:22924777   PMID:22980500   PMID:22984144   PMID:22991985  
PMID:23079635   PMID:23504711   PMID:23526143   PMID:23528921   PMID:23578768   PMID:23715757   PMID:23784669   PMID:23828562   PMID:23832258   PMID:24282679   PMID:24686056   PMID:24783193  
PMID:24816252   PMID:24975552   PMID:25036362   PMID:25260086   PMID:25339205   PMID:25532042   PMID:25549319   PMID:25598081   PMID:25708815   PMID:26037302   PMID:26106157   PMID:26372769  
PMID:26672987   PMID:26760575   PMID:27470510   PMID:28886991   PMID:29196930   PMID:29227475   PMID:30237084   PMID:30277667   PMID:30407793   PMID:30472260   PMID:30565457   PMID:30941737  
PMID:30962574   PMID:31014671   PMID:31353262   PMID:32037090   PMID:32161117   PMID:32265301   PMID:32324389   PMID:32375633   PMID:32398127   PMID:32694731   PMID:33564083   PMID:34064822  
PMID:34174394   PMID:34428433   PMID:35013218   PMID:35129022   PMID:35833141   PMID:36442529   PMID:37047037  


Genomics

Comparative Map Data
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,589,497 - 14,604,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,555,472 - 16,571,790 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALOX12
52 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p13.2-13.1(chr17:5732977-8038822)x1 copy number loss See cases [RCV000051043] Chr17:5732977..8038822 [GRCh38]
Chr17:5636297..7942140 [GRCh37]
Chr17:5577021..7882865 [NCBI36]
Chr17:17p13.2-13.1		 pathogenic
GRCh38/hg38 17p13.1(chr17:6958978-8335684)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052457]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052457]|See cases [RCV000052457] Chr17:6958978..8335684 [GRCh38]
Chr17:6862297..8239002 [GRCh37]
Chr17:6803021..8179727 [NCBI36]
Chr17:17p13.1		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:3601515-7178024)x1 copy number loss See cases [RCV000053406] Chr17:3601515..7178024 [GRCh38]
Chr17:3504809..7081343 [GRCh37]
Chr17:3451558..7022067 [NCBI36]
Chr17:17p13.2-13.1		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:6307904-8842949)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053407]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053407]|See cases [RCV000053407] Chr17:6307904..8842949 [GRCh38]
Chr17:6211224..8746266 [GRCh37]
Chr17:6151948..8686991 [NCBI36]
Chr17:17p13.2-13.1		 pathogenic
GRCh38/hg38 17p13.1(chr17:6958978-7491129)x3 copy number gain See cases [RCV000133763] Chr17:6958978..7491129 [GRCh38]
Chr17:6862297..7394448 [GRCh37]
Chr17:6803021..7335172 [NCBI36]
Chr17:17p13.1		 uncertain significance
GRCh38/hg38 17p13.3-13.1(chr17:198748-7491129)x3 copy number gain See cases [RCV000134970] Chr17:198748..7491129 [GRCh38]
Chr17:50690..7394448 [GRCh37]
Chr17:48539..7335172 [NCBI36]
Chr17:17p13.3-13.1		 pathogenic
GRCh38/hg38 17p13.2-12(chr17:5732953-12095349)x3 copy number gain See cases [RCV000134851] Chr17:5732953..12095349 [GRCh38]
Chr17:5636273..11998666 [GRCh37]
Chr17:5576997..11939391 [NCBI36]
Chr17:17p13.2-12		 pathogenic
GRCh38/hg38 17p13.3-13.1(chr17:162016-7697012)x1 copy number loss See cases [RCV000138214] Chr17:162016..7697012 [GRCh38]
Chr17:45835..7600330 [GRCh37]
Chr17:11807..7541055 [NCBI36]
Chr17:17p13.3-13.1		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:6361393-7750863)x3 copy number gain See cases [RCV000138220] Chr17:6361393..7750863 [GRCh38]
Chr17:6264713..7654181 [GRCh37]
Chr17:6205437..7594906 [NCBI36]
Chr17:17p13.2-13.1		 likely pathogenic
GRCh38/hg38 17p13.3-12(chr17:162016-12343901)x3 copy number gain See cases [RCV000138531] Chr17:162016..12343901 [GRCh38]
Chr17:45835..12247218 [GRCh37]
Chr17:11807..12187943 [NCBI36]
Chr17:17p13.3-12		 pathogenic
GRCh38/hg38 17p13.1(chr17:6891357-7264234)x3 copy number gain See cases [RCV000139216] Chr17:6891357..7264234 [GRCh38]
Chr17:6794676..7167553 [GRCh37]
Chr17:6735400..7108277 [NCBI36]
Chr17:17p13.1		 uncertain significance
GRCh38/hg38 17p13.3-12(chr17:150732-14764202)x3 copy number gain See cases [RCV000142236] Chr17:150732..14764202 [GRCh38]
Chr17:525..14667519 [GRCh37]
Chr17:525..14608244 [NCBI36]
Chr17:17p13.3-12		 pathogenic
GRCh37/hg19 17p13.1(chr17:6575869-7002388)x3 copy number gain See cases [RCV000448314] Chr17:6575869..7002388 [GRCh37]
Chr17:17p13.1		 uncertain significance
GRCh37/hg19 17p13.3-12(chr17:525-15027737)x3 copy number gain See cases [RCV000511786] Chr17:525..15027737 [GRCh37]
Chr17:17p13.3-12		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_000697.3(ALOX12):c.1796G>A (p.Arg599His) single nucleotide variant Inborn genetic diseases [RCV003253760] Chr17:7010110 [GRCh38]
Chr17:6913429 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.395T>G (p.Leu132Arg) single nucleotide variant Inborn genetic diseases [RCV003286712] Chr17:6998566 [GRCh38]
Chr17:6901885 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1091C>T (p.Thr364Ile) single nucleotide variant Inborn genetic diseases [RCV003248369] Chr17:7001741 [GRCh38]
Chr17:6905060 [GRCh37]
Chr17:17p13.1		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-12(chr17:525-11186432)x3 copy number gain not provided [RCV000683866] Chr17:525..11186432 [GRCh37]
Chr17:17p13.3-12		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_000697.3(ALOX12):c.1092T>G (p.Thr364=) single nucleotide variant not provided [RCV001644329] Chr17:7001742 [GRCh38]
Chr17:6905061 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.337+98T>G single nucleotide variant not provided [RCV001667134] Chr17:6997125 [GRCh38]
Chr17:6900444 [GRCh37]
Chr17:17p13.1		 benign
NC_000017.11:g.6995902G>A single nucleotide variant not provided [RCV001534696] Chr17:6995902 [GRCh38]
Chr17:6899221 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.646+84T>C single nucleotide variant not provided [RCV001534758] Chr17:6999140 [GRCh38]
Chr17:6902459 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.951+200C>T single nucleotide variant not provided [RCV001641811] Chr17:7000679 [GRCh38]
Chr17:6903998 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.765G>A (p.Ser255=) single nucleotide variant not provided [RCV001666545] Chr17:6999424 [GRCh38]
Chr17:6902743 [GRCh37]
Chr17:17p13.1		 benign
NC_000017.10:g.(?_6589506)_(8151374_?)dup duplication Common variable immunodeficiency [RCV001338841]|Dyskeratosis congenita [RCV001031775] Chr17:6589506..8151374 [GRCh37]
Chr17:17p13.1		 uncertain significance
GRCh37/hg19 17p13.1(chr17:6800893-7304696)x1 copy number loss not provided [RCV001006866] Chr17:6800893..7304696 [GRCh37]
Chr17:17p13.1		 pathogenic
GRCh37/hg19 17p13.1(chr17:6826243-7311408)x3 copy number gain not provided [RCV000849961] Chr17:6826243..7311408 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1211G>A (p.Arg404Gln) single nucleotide variant not provided [RCV000964551] Chr17:7005306 [GRCh38]
Chr17:6908625 [GRCh37]
Chr17:17p13.1		 likely benign
NM_000697.3(ALOX12):c.782A>G (p.Gln261Arg) single nucleotide variant not provided [RCV001615463] Chr17:6999441 [GRCh38]
Chr17:6902760 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1248+241G>A single nucleotide variant not provided [RCV001638958] Chr17:7005584 [GRCh38]
Chr17:6908903 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1541-264T>A single nucleotide variant not provided [RCV001651934] Chr17:7009483 [GRCh38]
Chr17:6912802 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.338-156G>A single nucleotide variant not provided [RCV001692825] Chr17:6998353 [GRCh38]
Chr17:6901672 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.542+23G>A single nucleotide variant not provided [RCV001667223] Chr17:6998860 [GRCh38]
Chr17:6902179 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1452A>G (p.Gln484=) single nucleotide variant not provided [RCV001621592] Chr17:7006519 [GRCh38]
Chr17:6909838 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1540+282A>G single nucleotide variant not provided [RCV001616995] Chr17:7006889 [GRCh38]
Chr17:6910208 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1541-20G>A single nucleotide variant not provided [RCV001599061] Chr17:7009727 [GRCh38]
Chr17:6913046 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.566G>A (p.Arg189His) single nucleotide variant not provided [RCV000974292] Chr17:6998976 [GRCh38]
Chr17:6902295 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1289G>A (p.Arg430His) single nucleotide variant not provided [RCV000887080] Chr17:7005898 [GRCh38]
Chr17:6909217 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.808-118G>A single nucleotide variant not provided [RCV001676441] Chr17:7000218 [GRCh38]
Chr17:6903537 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.136-69G>A single nucleotide variant not provided [RCV001595363] Chr17:6996757 [GRCh38]
Chr17:6900076 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.807+25A>T single nucleotide variant not provided [RCV001659314] Chr17:6999491 [GRCh38]
Chr17:6902810 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.337+37T>C single nucleotide variant not provided [RCV001608382] Chr17:6997064 [GRCh38]
Chr17:6900383 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1540+285T>G single nucleotide variant not provided [RCV001674905] Chr17:7006892 [GRCh38]
Chr17:6910211 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1418+32C>T single nucleotide variant not provided [RCV001637562] Chr17:7006059 [GRCh38]
Chr17:6909378 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1161+228C>T single nucleotide variant not provided [RCV001650357] Chr17:7002039 [GRCh38]
Chr17:6905358 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.807+102A>G single nucleotide variant not provided [RCV001716035] Chr17:6999568 [GRCh38]
Chr17:6902887 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.965A>G (p.Asn322Ser) single nucleotide variant not provided [RCV001617394] Chr17:7001615 [GRCh38]
Chr17:6904934 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1902G>A (p.Leu634=) single nucleotide variant not provided [RCV001687575] Chr17:7010333 [GRCh38]
Chr17:6913652 [GRCh37]
Chr17:17p13.1		 benign
NC_000017.11:g.6995799C>T single nucleotide variant not provided [RCV001684141] Chr17:6995799 [GRCh38]
Chr17:6899118 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.337+16C>T single nucleotide variant not provided [RCV001713734] Chr17:6997043 [GRCh38]
Chr17:6900362 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.1418+32_1418+33del deletion not provided [RCV001649090] Chr17:7006059..7006060 [GRCh38]
Chr17:6909378..6909379 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.951+146G>A single nucleotide variant not provided [RCV001536742] Chr17:7000625 [GRCh38]
Chr17:6903944 [GRCh37]
Chr17:17p13.1		 benign
GRCh37/hg19 17p13.1(chr17:6650649-8040151)x3 copy number gain not provided [RCV001259299] Chr17:6650649..8040151 [GRCh37]
Chr17:17p13.1		 pathogenic
NC_000017.10:g.(?_6328780)_(7128416_?)dup duplication Developmental and epileptic encephalopathy, 25 [RCV001320321] Chr17:6328780..7128416 [GRCh37]
Chr17:17p13.2-13.1		 uncertain significance
NC_000017.10:g.(?_6589506)_(7128436_?)del deletion Very long chain acyl-CoA dehydrogenase deficiency [RCV001391032] Chr17:6589506..7128436 [GRCh37]
Chr17:17p13.1		 pathogenic
NM_000697.3(ALOX12):c.135+160T>C single nucleotide variant not provided [RCV001540403] Chr17:6996412 [GRCh38]
Chr17:6899731 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.135+58C>T single nucleotide variant not provided [RCV001619457] Chr17:6996310 [GRCh38]
Chr17:6899629 [GRCh37]
Chr17:17p13.1		 benign
NM_000697.3(ALOX12):c.123C>G (p.Pro41=) single nucleotide variant not provided [RCV001681130] Chr17:6996240 [GRCh38]
Chr17:6899559 [GRCh37]
Chr17:17p13.1		 benign
NC_000017.10:g.(?_6328780)_(7606804_?)dup duplication Congenital myasthenic syndrome 2A [RCV003109217]|Very long chain acyl-CoA dehydrogenase deficiency [RCV003119078] Chr17:6328780..7606804 [GRCh37]
Chr17:17p13.2-13.1		 uncertain significance
NM_000697.3(ALOX12):c.275T>C (p.Val92Ala) single nucleotide variant Inborn genetic diseases [RCV002836935] Chr17:6996965 [GRCh38]
Chr17:6900284 [GRCh37]
Chr17:17p13.1		 likely benign
NM_000697.3(ALOX12):c.1988T>C (p.Ile663Thr) single nucleotide variant Inborn genetic diseases [RCV002744488] Chr17:7010419 [GRCh38]
Chr17:6913738 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1604C>T (p.Thr535Met) single nucleotide variant Inborn genetic diseases [RCV002709527] Chr17:7009810 [GRCh38]
Chr17:6913129 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.966C>A (p.Asn322Lys) single nucleotide variant Inborn genetic diseases [RCV002788841] Chr17:7001616 [GRCh38]
Chr17:6904935 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.340C>T (p.Arg114Cys) single nucleotide variant Inborn genetic diseases [RCV002717858] Chr17:6998511 [GRCh38]
Chr17:6901830 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1010C>G (p.Pro337Arg) single nucleotide variant Inborn genetic diseases [RCV002719968] Chr17:7001660 [GRCh38]
Chr17:6904979 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1093C>G (p.His365Asp) single nucleotide variant Inborn genetic diseases [RCV002898290] Chr17:7001743 [GRCh38]
Chr17:6905062 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.728G>A (p.Arg243His) single nucleotide variant Inborn genetic diseases [RCV002679575] Chr17:6999387 [GRCh38]
Chr17:6902706 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.404G>A (p.Arg135Lys) single nucleotide variant Inborn genetic diseases [RCV003201987] Chr17:6998575 [GRCh38]
Chr17:6901894 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1504A>T (p.Ile502Phe) single nucleotide variant Inborn genetic diseases [RCV003306680] Chr17:7006571 [GRCh38]
Chr17:6909890 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.797A>G (p.Lys266Arg) single nucleotide variant Inborn genetic diseases [RCV003199245] Chr17:6999456 [GRCh38]
Chr17:6902775 [GRCh37]
Chr17:17p13.1		 likely benign
GRCh38/hg38 17p13.3-12(chr17:165730-11404096)x3 copy number gain Chromosome 17p13.3 duplication syndrome [RCV003327726] Chr17:165730..11404096 [GRCh38]
Chr17:17p13.3-12		 pathogenic
NM_000697.3(ALOX12):c.1029A>C (p.Ala343=) single nucleotide variant not provided [RCV003428091] Chr17:7001679 [GRCh38]
Chr17:6904998 [GRCh37]
Chr17:17p13.1		 likely benign
NM_000697.3(ALOX12):c.349G>C (p.Gly117Arg) single nucleotide variant not provided [RCV003428090] Chr17:6998520 [GRCh38]
Chr17:6901839 [GRCh37]
Chr17:17p13.1		 likely benign
GRCh37/hg19 17p13.3-11.2(chr17:525-21510992)x3 copy number gain not specified [RCV003987215] Chr17:525..21510992 [GRCh37]
Chr17:17p13.3-11.2		 pathogenic
NM_000697.3(ALOX12):c.1208C>T (p.Ala403Val) single nucleotide variant Inborn genetic diseases [RCV003356265] Chr17:7005303 [GRCh38]
Chr17:6908622 [GRCh37]
Chr17:17p13.1		 uncertain significance
NM_000697.3(ALOX12):c.1619A>G (p.His540Arg) single nucleotide variant Inborn genetic diseases [RCV003361484] Chr17:7009825 [GRCh38]
Chr17:6913144 [GRCh37]
Chr17:17p13.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:638
Count of miRNA genes:447
Interacting mature miRNAs:474
Transcripts:ENST00000251535, ENST00000406228, ENST00000480801
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH102167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,898,262 - 6,898,440UniSTSGRCh37
Build 36176,838,986 - 6,839,164RGDNCBI36
Celera176,923,830 - 6,924,008RGD
Cytogenetic Map17p13.1UniSTS
GeneMap99-GB4 RH Map1753.5UniSTS
RH122370  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,903,294 - 6,903,574UniSTSGRCh37
Build 36176,844,018 - 6,844,298RGDNCBI36
Celera176,928,861 - 6,929,141RGD
Cytogenetic Map17p13.1UniSTS
HuRef176,797,112 - 6,797,392UniSTS
TNG Radiation Hybrid Map173479.0UniSTS
GDB:607713  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,898,820 - 6,899,021UniSTSGRCh37
Build 36176,839,544 - 6,839,745RGDNCBI36
Celera176,924,388 - 6,924,589RGD
Cytogenetic Map17p13.1UniSTS
HuRef176,792,639 - 6,792,840UniSTS
csnpalox12-pcr1-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,899,288 - 6,899,733UniSTSGRCh37
Build 36176,840,012 - 6,840,457RGDNCBI36
Celera176,924,856 - 6,925,301RGD
Cytogenetic Map17p13.1UniSTS
HuRef176,793,107 - 6,793,552UniSTS
WI-17813  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,905,319 - 6,905,457UniSTSGRCh37
Build 36176,846,043 - 6,846,181RGDNCBI36
Celera176,930,886 - 6,931,024RGD
Cytogenetic Map17p13.1UniSTS
HuRef176,799,138 - 6,799,276UniSTS
GeneMap99-GB4 RH Map1753.5UniSTS
Whitehead-RH Map1777.9UniSTS
SHGC-12725  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,913,756 - 6,914,034UniSTSGRCh37
Build 36176,854,480 - 6,854,758RGDNCBI36
Celera176,939,261 - 6,939,539RGD
Cytogenetic Map17p13.1UniSTS
HuRef176,807,449 - 6,807,727UniSTS
Stanford-G3 RH Map17422.0UniSTS
NCBI RH Map17175.9UniSTS
GeneMap99-G3 RH Map17422.0UniSTS
ALOX12_4210  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,913,633 - 6,914,062UniSTSGRCh37
Build 36176,854,357 - 6,854,786RGDNCBI36
Celera176,939,138 - 6,939,567RGD
HuRef176,807,326 - 6,807,755UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 6
Medium 6 115 1 31 139 1194 3 2 6 114 25 35 623
Low 2318 2200 1500 415 1692 284 2465 1098 2311 349 1280 1505 137 1194 1494 2
Below cutoff 84 668 194 154 93 158 693 1072 1375 57 41 37 1 1 10 671 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000251535   ⟹   ENSP00000251535
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)Ensembl
RefSeq Acc Id: ENST00000406228
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl177,009,489 - 7,010,736 (+)Ensembl
RefSeq Acc Id: ENST00000480801   ⟹   ENSP00000467033
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl176,996,982 - 7,000,469 (+)Ensembl
RefSeq Acc Id: NM_000697   ⟹   NP_000688
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38176,996,049 - 7,010,754 (+)NCBI
GRCh37176,899,384 - 6,914,055 (+)ENTREZGENE
GRCh37176,899,384 - 6,914,055 (+)NCBI
Build 36176,840,108 - 6,854,779 (+)NCBI Archive
HuRef176,793,203 - 6,807,748 (+)ENTREZGENE
CHM1_1176,908,840 - 6,923,485 (+)NCBI
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011523780   ⟹   XP_011522082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38176,996,049 - 7,010,754 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000688   ⟸   NM_000697
- UniProtKB: Q6ISF8 (UniProtKB/Swiss-Prot),   O95569 (UniProtKB/Swiss-Prot),   Q9UQM4 (UniProtKB/Swiss-Prot),   P18054 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011522082   ⟸   XM_011523780
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000467033   ⟸   ENST00000480801
RefSeq Acc Id: ENSP00000251535   ⟸   ENST00000251535
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18054-F1-model_v2 AlphaFold P18054 1-663 view protein structure

Promoters
RGD ID:7233607
Promoter ID:EPDNEW_H22549
Type:initiation region
Name:ALOX12_1
Description:arachidonate 12-lipoxygenase, 12S type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38176,996,049 - 6,996,109EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:429 AgrOrtholog
COSMIC ALOX12 COSMIC
Ensembl Genes ENSG00000108839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000251535 ENTREZGENE
  ENST00000251535.11 UniProtKB/Swiss-Prot
  ENST00000480801.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot
GTEx ENSG00000108839 GTEx
HGNC ID HGNC:429 ENTREZGENE
Human Proteome Map ALOX12 Human Proteome Map
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot
  LipOase_Fe_BS UniProtKB/Swiss-Prot
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot
  PLAT_LOX_verte UniProtKB/Swiss-Prot
KEGG Report hsa:239 UniProtKB/Swiss-Prot
NCBI Gene 239 ENTREZGENE
OMIM 152391 OMIM
PANTHER LIPOXYGENASE UniProtKB/TrEMBL
  POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11771 UniProtKB/Swiss-Prot
Pfam Lipoxygenase UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
PharmGKB PA45 PharmGKB
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot
SMART LH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot
UniProt K7ENN9_HUMAN UniProtKB/TrEMBL
  LOX12_HUMAN UniProtKB/Swiss-Prot
  O95569 ENTREZGENE
  P18054 ENTREZGENE
  Q6ISF8 ENTREZGENE
  Q9UQM4 ENTREZGENE
UniProt Secondary O95569 UniProtKB/Swiss-Prot
  Q6ISF8 UniProtKB/Swiss-Prot
  Q9UQM4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-10 ALOX12  arachidonate 12-lipoxygenase, 12S type    arachidonate 12-lipoxygenase  Symbol and/or name change 5135510 APPROVED