Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of LIMS1 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of LIMS1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of LIMS1 protein | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LIMS1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LIMS1 mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LIMS1 mRNA | CTD | PMID:26377647 | 2,4,6-tribromophenol | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,6-dinitrotoluene | affects expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of LIMS1 mRNA | CTD | PMID:21346803 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of LIMS1 protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of LIMS1 mRNA | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIMS1 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of LIMS1 mRNA | CTD | PMID:28973697 | 4-vinylcyclohexene dioxide | affects expression | EXP | | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of LIMS1 mRNA | CTD | PMID:20829426 | 5-aza-2'-deoxycytidine | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Decitabine results in increased expression of LIMS1 mRNA | CTD | PMID:19194470 | 5-azacytidine | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Azacitidine results in increased expression of LIMS1 mRNA | CTD | PMID:19194470 | 6-propyl-2-thiouracil | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of LIMS1 mRNA | CTD | PMID:24780913 and PMID:30047161 | acetamide | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of LIMS1 mRNA | CTD | PMID:31881176 | aconitine | decreases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Aconitine results in decreased expression of LIMS1 protein | CTD | PMID:33236894 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of LIMS1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | LIMS1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of LIMS1 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of LIMS1 mRNA | CTD | PMID:21934132 and PMID:33167477 | amitrole | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of LIMS1 mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of LIMS1 mRNA | CTD | PMID:33212167 | Aroclor 1254 | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of LIMS1 mRNA | CTD | PMID:16934159 | arsenite(3-) | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to LIMS1 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases methylation | ISO | LIMS1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LIMS1 5' UTR | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of LIMS1 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LIMS1 mRNA | CTD | PMID:21932408 and PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LIMS1 protein | CTD | PMID:35999755 | bisphenol A | decreases methylation | ISO | LIMS1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of LIMS1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of LIMS1 protein | CTD | PMID:31675489 | bisphenol A | decreases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LIMS1 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of LIMS1 protein and bisphenol A results in increased expression of LIMS4 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIMS1 mRNA | CTD | PMID:28628672 | bortezomib | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of LIMS1 mRNA | CTD | PMID:20977926 | calcitriol | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of LIMS1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of LIMS1 mRNA | CTD | PMID:21592394 | cisplatin | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of LIMS1 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of LIMS1 mRNA | CTD | PMID:27392435 | cobalt dichloride | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | cobaltous chloride results in increased expression of LIMS1 mRNA | CTD | PMID:24386269 | cobalt dichloride | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of LIMS1 mRNA | CTD | PMID:19376846 | copper(II) sulfate | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of LIMS1 mRNA | CTD | PMID:19549813 | crocidolite asbestos | affects expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of LIMS1 mRNA | CTD | PMID:25757056 | cyclosporin A | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of LIMS1 mRNA | CTD | PMID:20106945 and PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of LIMS1 protein | CTD | PMID:31675489 | dexamethasone | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIMS1 mRNA | CTD | PMID:28628672 | dextran sulfate | decreases expression | EXP | | 6480464 | Dextran Sulfate results in decreased expression of LIMS1 protein | CTD | PMID:35999755 | dibutyl phthalate | decreases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of LIMS1 mRNA | CTD | PMID:24893172 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of LIMS1 mRNA | CTD | PMID:17361019 and PMID:21266533 | ethanol | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LIMS1 mRNA | CTD | PMID:30517762 | folic acid | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of LIMS1 mRNA] | CTD | PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of LIMS1 mRNA | CTD | PMID:25629700 | gentamycin | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of LIMS1 mRNA | CTD | PMID:33387578 | hydrogen cyanide | increases expression | EXP | | 6480464 | Hydrogen Cyanide results in increased expression of LIMS1 mRNA | CTD | PMID:33914522 | indometacin | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LIMS1 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LIMS1 protein | CTD | PMID:32959892 | methimazole | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of LIMS1 mRNA | CTD | PMID:30047161 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of LIMS1 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of LIMS1 mRNA | CTD | PMID:19159669 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of LIMS1 mRNA | CTD | PMID:23091169 | phenylephrine | affects localization | ISO | Lims1 (Rattus norvegicus) | 6480464 | Phenylephrine affects the localization of LIMS1 protein | CTD | PMID:16170337 | poly(vinylpyrrolidone) | multiple interactions | ISO | Lims1 (Rattus norvegicus) | 6480464 | [Silver analog co-treated with Povidone] results in increased expression of LIMS1 mRNA | CTD | PMID:25194297 | potassium cyanide | increases expression | EXP | | 6480464 | Potassium Cyanide results in increased expression of LIMS1 mRNA | CTD | PMID:33914522 | silver atom | multiple interactions | ISO | Lims1 (Rattus norvegicus) | 6480464 | [Silver analog co-treated with Povidone] results in increased expression of LIMS1 mRNA | CTD | PMID:25194297 | silver(0) | multiple interactions | ISO | Lims1 (Rattus norvegicus) | 6480464 | [Silver analog co-treated with Povidone] results in increased expression of LIMS1 mRNA | CTD | PMID:25194297 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of LIMS1 mRNA | CTD | PMID:21795629 | sodium dichromate | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | sodium bichromate results in decreased expression of LIMS1 mRNA | CTD | PMID:17685462 | succimer | multiple interactions | EXP | | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of LIMS1 mRNA | CTD | PMID:26378955 | sulfadimethoxine | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of LIMS1 mRNA | CTD | PMID:30047161 | temozolomide | decreases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of LIMS1 mRNA | CTD | PMID:31758290 | tert-butyl hydroperoxide | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in increased expression of LIMS1 mRNA | CTD | PMID:15336504 | testosterone | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Testosterone results in increased expression of LIMS1 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | LIMS1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of LIMS1 mRNA | CTD | PMID:21592394 | testosterone enanthate | affects expression | ISO | LIMS1 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of LIMS1 mRNA | CTD | PMID:17440010 | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LIMS1 mRNA | CTD | PMID:30517762 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of LIMS1 mRNA | CTD | PMID:31919559 | thimerosal | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of LIMS1 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of LIMS1 mRNA | CTD | PMID:34492290 | valproic acid | decreases methylation | ISO | LIMS1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of LIMS1 gene | CTD | PMID:29154799 | vinclozolin | increases expression | ISO | Lims1 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of LIMS1 mRNA | CTD | PMID:23555832 | vincristine | increases expression | ISO | LIMS1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of LIMS1 mRNA | CTD | PMID:23649840 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Mouse brain organization revealed through direct genome-scale TF expression analysis. | Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7. |
| 2. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 3. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 4. | ILK, PINCH and parvin: the tIPP of integrin signalling. | Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31. |
| 5. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 6. | MGD IEA | MGD IEA |
| 7. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 8. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 9. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:7517666 | PMID:8889548 | PMID:9763658 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11237772 | PMID:11386759 | PMID:11544199 | PMID:12432066 | PMID:12466305 |
| PMID:12477932 | PMID:12520002 | PMID:12651156 | PMID:14610273 | PMID:15489334 | PMID:15565145 | PMID:15782199 | PMID:15798193 | PMID:15872073 | PMID:15878342 | PMID:15976450 | PMID:16141072 |
| PMID:16141073 | PMID:16170337 | PMID:16317048 | PMID:16602821 | PMID:17047147 | PMID:17272814 | PMID:17878168 | PMID:17967808 | PMID:18287559 | PMID:18799693 | PMID:19349584 | PMID:19435803 |
| PMID:19652092 | PMID:19829382 | PMID:20164304 | PMID:20412781 | PMID:20530873 | PMID:20927395 | PMID:20932939 | PMID:21267068 | PMID:21278135 | PMID:21873635 | PMID:22083510 | PMID:22922362 |
| PMID:22946061 | PMID:23554879 | PMID:23612611 | PMID:23658024 | PMID:24058607 | PMID:24457600 | PMID:24719101 | PMID:24952961 | PMID:25609703 | PMID:27113764 | PMID:28546219 | PMID:30134070 |
| PMID:31723057 | PMID:31801973 | PMID:33004813 | PMID:33083097 | PMID:34283311 | PMID:35401828 | PMID:36385586 | PMID:36743414 | PMID:38062244 |
Genomics
Comparative Map Data
| Lims1 (Mus musculus - house mouse) |
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| LIMS1 (Homo sapiens - human) |
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| Lims1 (Rattus norvegicus - Norway rat) |
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| Lims1 (Chinchilla lanigera - long-tailed chinchilla) |
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| LIMS1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| LIMS1 (Canis lupus familiaris - dog) |
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| Lims1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| LIMS1 (Sus scrofa - pig) |
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| LIMS1 (Chlorocebus sabaeus - green monkey) |
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| Lims1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Lims1
697 total Variants 
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