CXCR2 (C-X-C motif chemokine receptor 2)

Gene: CXCR2 (C-X-C motif chemokine receptor 2) Canis lupus familiaris

Analyze

Symbol:

CXCR2

Name:

C-X-C motif chemokine receptor 2

RGD ID:

12158316

Description:

ENCODES a protein that exhibits chemokine receptor activity (ortholog); interleukin-8 receptor activity (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); cell surface receptor signaling pathway (ortholog); cellular defense response (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); acute pyelonephritis (ortholog); alacrima, achalasia, and impaired intellectual development syndrome (ortholog); FOUND IN cell surface (ortholog); mast cell granule (ortholog); microtubule cytoskeleton (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C-X-C chemokine receptor type 2; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL8RB; interleukin 8 receptor, beta

RGD Orthologs

Human

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	24,831,351 - 24,846,387 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	24,843,171 - 24,844,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,659,341 - 25,664,768 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	24,847,511 - 24,862,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	24,855,136 - 24,860,563 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,760,631 - 24,766,058 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,694,995 - 24,700,420 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,714,358 - 24,719,785 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

acute pyelonephritis (ISO)

alacrima, achalasia, and impaired intellectual development syndrome (ISO)

allergic disease (ISO)

brain disease (ISO)

bronchopneumonia (ISO)

cerebrotendinous xanthomatosis (ISO)

chronic obstructive pulmonary disease (ISO)

colitis (ISO)

common cold (ISO)

COVID-19 (ISO)

cystic fibrosis (ISO)

demyelinating disease (ISO)

dengue disease (ISO)

Diabetic Nephropathies (ISO)

end stage renal disease (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

genetic disease (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

IgA glomerulonephritis (ISO)

Inflammation (ISO)

juvenile rheumatoid arthritis (ISO)

Kidney Reperfusion Injury (ISO)

Legionnaires' disease (ISO)

liver disease (ISO)

lung disease (ISO)

Lung Injury (ISO)

Lyme disease (ISO)

mastitis (ISO)

middle cerebral artery infarction (ISO)

nephritis (ISO)

nephroblastoma (ISO)

Neuralgia (ISO)

Neurodevelopmental Disorders (ISO)

paroxysmal nonkinesigenic dyskinesia 1 (ISO)

periapical periodontitis (ISO)

pneumonia (ISO)

pulmonary fibrosis (ISO)

pyelonephritis (ISO)

renal cell carcinoma (ISO)

Sepsis (ISO)

systemic lupus erythematosus (ISO)

Transplant Rejection (ISO)

ulcerative colitis (ISO)

urinary bladder cancer (ISO)

urinary tract infection (ISO)

Vascular Remodeling (ISO)

WHIM Syndrome 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute inflammatory response to antigenic stimulus (ISO)

calcium-mediated signaling (IBA,IEA)

cell surface receptor signaling pathway (ISO)

cellular defense response (ISO)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IBA,IEA)

interleukin-8-mediated signaling pathway (ISO)

metanephric tubule morphogenesis (ISO)

midbrain development (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of neutrophil apoptotic process (ISO)

neutrophil activation (ISO)

neutrophil chemotaxis (IBA,IEA,ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of cardiac muscle cell apoptotic process (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cytosolic calcium ion concentration (IBA,IEA,ISO)

positive regulation of leukocyte chemotaxis (ISO)

positive regulation of neutrophil chemotaxis (ISO)

positive regulation of vascular permeability (ISO)

receptor internalization (ISO)

Cellular Component

cell surface (ISO)

external side of plasma membrane (IBA,IEA)

mast cell granule (ISO)

membrane (IEA)

microtubule cytoskeleton (ISO)

mitotic spindle (ISO)

nucleoplasm (ISO)

plasma membrane (IEA)

Molecular Function

C-C chemokine binding (IBA,IEA)

C-C chemokine receptor activity (IBA,IEA)

C-X-C chemokine receptor activity (IEA)

chemokine receptor activity (ISO)

G protein-coupled receptor activity (IEA)

interleukin-8 binding (IEA)

interleukin-8 receptor activity (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:10647821	PMID:21863548	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CXCR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	24,831,351 - 24,846,387 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	24,843,171 - 24,844,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,659,341 - 25,664,768 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	24,847,511 - 24,862,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	24,855,136 - 24,860,563 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,760,631 - 24,766,058 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,694,995 - 24,700,420 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,714,358 - 24,719,785 (+)	NCBI		UU_Cfam_GSD_1.0

CXCR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,125,294 - 218,137,251 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,125,289 - 218,137,251 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	218,990,017 - 219,001,974 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,698,991 - 218,710,220 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	218,816,251 - 218,827,481	NCBI
Celera	2	212,756,449 - 212,768,411 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	210,842,767 - 210,854,732 (+)	NCBI		HuRef
CHM1_1	2	218,996,503 - 219,008,469 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,610,987 - 218,622,946 (+)	NCBI		T2T-CHM13v2.0

Variants

Variants in CXCR2
235 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium					1						1
Low			9	6	11	6	8		1		10	8
Below cutoff	10	9	35	6		6	4	11	21	16	9	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005640416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005640417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF047047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000023204 ⟹ ENSCAFP00000021547

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	37	24,843,171 - 24,844,247 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845046624 ⟹ ENSCAFP00845036602

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	37	24,855,136 - 24,860,563 (+)	Ensembl

RefSeq Acc Id:

NM_001003151 ⟹ NP_001003151

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	24,839,114 - 24,844,541 (+)	NCBI
Dog10K_Boxer_Tasha	37	25,659,341 - 25,664,768 (+)	NCBI
ROS_Cfam_1.0	37	24,855,136 - 24,860,563 (+)	NCBI
UMICH_Zoey_3.1	37	24,760,631 - 24,766,058 (+)	NCBI
UNSW_CanFamBas_1.0	37	24,694,995 - 24,700,420 (+)	NCBI
UU_Cfam_GSD_1.0	37	24,714,358 - 24,719,785 (+)	NCBI

Sequence:

show sequence

CCCTGTCAGTCAGGCACATCTGCTCTCCTGGGCGAGTCCTACAGGTGAAAGGCCCAGACTCCTG
GCCAGGATTTAAGCTTCCCTCCAATATGGAATACATTAACTGGGATAATTACAGCCTGGAGGAT
CTCTTCGGTGATATTGATAATTATACTTACAACACGGAGATGCCCATAATTCCAGCAGACTCTG
CCCCATGCAGGCCAGAATCTCTGGACATCAACAAGTATGCTGTGGTTGTCATCTATGTCCTGGT
CTTTGTGCTGAACCTGCTGGGAAACTCCCTAGTCATAATGGTTGTCTTATACAGTCGGGTCAGT
CACTCTGTCACCGACGTCTATCTGCTGAACCTGGCCATAGCTGACCTGCTCTTCGCCTTGACCT
TGCCTATCTGGGCTGTCTCCAAGGTAAAGGGTTGGATCTTTGGCACACCCCTGTGCAAGATCGT
CTCGCTCCTGAAGGAAGTCAACTTCTACAGCAGCATCCTGCTGCTGGCCTGCATCAGCATGGAC
CGCTACCTGGCCATTGTCCATGCCACACGCACGCTGACCCAGAAGAGGCACTGGGTCAAGTTCA
TATGCTTAGGCATCTGGGCCCTGTCCCTCATCCTGTCCCTGCCCATCTTCGTCTTCCGCAGGGC
CATCAATCCCCCCTACTCCAGCCCAGTCTGCTACGAGGACATGGGTGCCAATACAACAAAATTG
CGGATAGTGATGCGGGCCCTGCCCCAGACCTTTGGCTTCATCGTGCCCCTGATGATCATGCTGT
TCTGCTATGGGCTCACCCTGCGCACGCTGTTTGAGGCCCACATGGGGCAGAAGCACCGGGCCAT
GCGGGTCATCTTTGCTGTCGTGCTCGTCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTG
GTCGCAGACACCCTCATGAGGCTCCAGGCCATTAAGGAGACCTGTCAGCGCCGCAATGACATTG
GCCGTGCCCTGGATGCCACCGAGATTCTGGGCTTCTTCCACAGCTGCCTTAATCCCCTCATCTA
TGCCTTCATTGGCCAGAAGTTTCGCCATGGACTCCTCAAGATCATGGCCTTCCATGGGCTCATC
AGCAAAGAGTACCTGCCCAAGGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGCGAACACTT
CTACTACTTTCTAAGCACCCCCTGCCCCGGTTGCAGTCCCTCAGGGCTCTCCCTCGCCATCAGC
ATCCCGTTCCAAACCTCATGTCCACTGGCTGTTCACAGTCTCTGTGTCAAGGCAGCTCCCAGCT
GTGGTTCCAGGGAGTTGCTGGGGCCACGTCCTTTTCAGGCCCATTGTATGGTTTAGGGAGCCTG
CCCTGCTGCCCCACCCCTTACTATAGCTACAGTGTCAGCTGCTAGAGCTCACTGAGCCCACAGC
ACTCTGTTCTCTGAGGCAGCTAAAGATGTTTAAAAGATATCCTTTTAAATGA

hide sequence

RefSeq Acc Id:

XM_038447291 ⟹ XP_038303219

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	24,852,071 - 24,862,398 (+)	NCBI

RefSeq Acc Id:

XM_038447292 ⟹ XP_038303220

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	24,847,511 - 24,862,398 (+)	NCBI

RefSeq Acc Id:

XM_038447293 ⟹ XP_038303221

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	24,852,068 - 24,862,398 (+)	NCBI

RefSeq Acc Id:

XM_038447294 ⟹ XP_038303222

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	24,847,550 - 24,862,398 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003151	(Get FASTA)	NCBI Sequence Viewer
	XP_038303219	(Get FASTA)	NCBI Sequence Viewer
	XP_038303220	(Get FASTA)	NCBI Sequence Viewer
	XP_038303221	(Get FASTA)	NCBI Sequence Viewer
	XP_038303222	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC98968	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000021542.4
	ENSCAFP00030036182.1
	ENSCAFP00040037264.1
	ENSCAFP00845036602
	ENSCAFP00845036602.1
GenBank Protein	O97571	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001003151 ⟸ NM_001003151

- UniProtKB:

O97571 (UniProtKB/Swiss-Prot), A0A8C0TK08 (UniProtKB/TrEMBL), A0A8I3PZU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEYINWDNYSLEDLFGDIDNYTYNTEMPIIPADSAPCRPESLDINKYAVVVIYVLVFVLNLLGN
SLVIMVVLYSRVSHSVTDVYLLNLAIADLLFALTLPIWAVSKVKGWIFGTPLCKIVSLLKEVNF
YSSILLLACISMDRYLAIVHATRTLTQKRHWVKFICLGIWALSLILSLPIFVFRRAINPPYSSP
VCYEDMGANTTKLRIVMRALPQTFGFIVPLMIMLFCYGLTLRTLFEAHMGQKHRAMRVIFAVVL
VFLLCWLPYNLVLVADTLMRLQAIKETCQRRNDIGRALDATEILGFFHSCLNPLIYAFIGQKFR
HGLLKIMAFHGLISKEYLPKDSRPSFVGSSSANTSTTF

hide sequence

RefSeq Acc Id:

ENSCAFP00000021547 ⟸ ENSCAFT00000023204

RefSeq Acc Id:	XP_038303220 ⟸ XM_038447292
- Peptide Label:	isoform X1
- UniProtKB:	O97571 (UniProtKB/Swiss-Prot), A0A8C0TK08 (UniProtKB/TrEMBL), A0A8I3PZU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303222 ⟸ XM_038447294
- Peptide Label:	isoform X1
- UniProtKB:	O97571 (UniProtKB/Swiss-Prot), A0A8C0TK08 (UniProtKB/TrEMBL), A0A8I3PZU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303221 ⟸ XM_038447293
- Peptide Label:	isoform X1
- UniProtKB:	O97571 (UniProtKB/Swiss-Prot), A0A8C0TK08 (UniProtKB/TrEMBL), A0A8I3PZU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303219 ⟸ XM_038447291
- Peptide Label:	isoform X1
- UniProtKB:	O97571 (UniProtKB/Swiss-Prot), A0A8C0TK08 (UniProtKB/TrEMBL), A0A8I3PZU6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845036602 ⟸ ENSCAFT00845046624

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000014612	UniProtKB/TrEMBL
	ENSCAFG00000014615	Ensembl
	ENSCAFG00030022578	UniProtKB/TrEMBL
	ENSCAFG00040022991	UniProtKB/TrEMBL
	ENSCAFG00845026443	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000023199.4	UniProtKB/TrEMBL
	ENSCAFT00030041482.1	UniProtKB/TrEMBL
	ENSCAFT00040042727.1	UniProtKB/TrEMBL
	ENSCAFT00845046624	ENTREZGENE
	ENSCAFT00845046624.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Chemokine_CXCR2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chemokine_CXCR_1/2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:478905	UniProtKB/TrEMBL
NCBI Gene	CXCR2	ENTREZGENE
PANTHER	C-X-C CHEMOKINE RECEPTOR TYPE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTRLEUKIN8R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTRLEUKN8BR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0P307_CANLF	UniProtKB/TrEMBL
	A0A8C0TK08	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3PZU6	ENTREZGENE, UniProtKB/TrEMBL
	CXCR2_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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