RGD Reference Report - Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. - Rat Genome Database

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Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.

Authors: Kang, MK  Li, J  Kim, JL  Gong, JH  Kwak, SN  Park, JH  Lee, JY  Lim, SS  Kang, YH 
Citation: Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
RGD ID: 7257674
Pubmed: PMID:22791342   (View Abstract at PubMed)
DOI: DOI:10.1152/ajprenal.00106.2012   (Journal Full-text)

Diabetic nephropathy (DN) is one of the major diabetic complications and the leading cause of end-stage renal disease. In early DN, renal injury and macrophage accumulation take place in the pathological environment of glomerular vessels adjacent to renal mesangial cells expressing proinflammatory mediators. Purple corn utilized as a daily food is rich in anthocyanins exerting disease-preventive activities as a functional food. This study elucidated whether anthocyanin-rich purple corn extract (PCA) could suppress monocyte activation and macrophage infiltration. In the in vitro study, human endothelial cells and THP-1 monocytes were cultured in conditioned media of human mesangial cells exposed to 33 mM glucose (HG-HRMC). PCA decreased the HG-HRMC-conditioned, media-induced expression of endothelial vascular cell adhesion molecule-1, E-selectin, and monocyte integrins-beta1 and -beta2 through blocking the mesangial Tyk2 pathway. In the in vivo animal study, db/db mice were treated with 10 mg/kg PCA daily for 8 wk. PCA attenuated CXCR2 induction and the activation of Tyk2 and STAT1/3 in db/db mice. Periodic acid-Schiff staining showed that PCA alleviated mesangial expansion-elicited renal injury in diabetic kidneys. In glomeruli, PCA attenuated the induction of intracellular cell adhesion molecule-1 and CD11b. PCA diminished monocyte chemoattractant protein-1 expression and macrophage inflammatory protein 2 transcription in the diabetic kidney, inhibiting the induction of the macrophage markers CD68 and F4/80. These results demonstrate that PCA antagonized the infiltration and accumulation of macrophages in diabetic kidneys through disturbing the mesangial IL-8-Tyk-STAT signaling pathway. Therefore, PCA may be a potential renoprotective agent treating diabetes-associated glomerulosclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies treatmentISOCxcr2 (Mus musculus)7257674; 7257674associated with Diabetes Mellitus and Type 2RGD 
Diabetic Nephropathies treatmentIDA 7257674associated with Diabetes Mellitus and Type 2RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcr2  (C-X-C motif chemokine receptor 2)

Genes (Mus musculus)
Cxcr2  (C-X-C motif chemokine receptor 2)

Genes (Homo sapiens)
CXCR2  (C-X-C motif chemokine receptor 2)


Additional Information