NPPA (natriuretic peptide A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NPPA (natriuretic peptide A) Pan paniscus
Analyze
Symbol: NPPA
Name: natriuretic peptide A
RGD ID: 11965159
Description: ENCODES a protein that exhibits hormone activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cell growth involved in cardiac muscle cell development (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN atrial natriuretic peptide signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN brush border (ortholog); glycinergic synapse (ortholog); mast cell granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: natriuretic peptides A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
aortic valve insufficiency  (ISO)
atrial standstill 1  (ISO)
atrial standstill 2  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (ISO)
Hypercapnia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
intrinsic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
patent ductus arteriosus  (ISO)
peritonitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Urination Disorders  (ISO)
vascular dementia  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
cardiac muscle hypertrophy in response to stress  (IEA,ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to mechanical stimulus  (ISO)
cGMP biosynthetic process  (IEA,ISO)
cGMP-mediated signaling  (IEA,ISO)
female pregnancy  (IEA)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of collecting lymphatic vessel constriction  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of systemic arterial blood pressure  (IEA,ISO)
neuropeptide signaling pathway  (IEA)
positive regulation of cardiac muscle contraction  (IEA)
positive regulation of cGMP-mediated signaling  (ISO)
positive regulation of heart rate  (IEA)
positive regulation of histamine secretion by mast cell  (ISO)
positive regulation of potassium ion export across plasma membrane  (IEA)
protein folding  (IEA)
receptor guanylyl cyclase signaling pathway  (IEA,ISO)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA)
regulation of blood pressure  (IEA)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
response to 3-methylcholanthrene  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
sodium ion export across plasma membrane  (IEA,ISO)
synaptic signaling via neuropeptide  (ISO)
system process  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)Ensemblpanpan1.1panPan2
NPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,845,709 - 11,848,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
T2T-CHM13v2.0111,389,795 - 11,391,868 (-)NCBIT2T-CHM13v2.0
Nppa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 Ensembl
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
Nppa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
Nppa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,060,735 - 2,063,003 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,061,196 - 2,062,805 (+)NCBIChiLan1.0ChiLan1.0
NPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0
Nppa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,918,845 - 71,921,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,919,557 - 71,921,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,829,057 - 65,830,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,942,412 - 119,946,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,944,532 - 119,945,917 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,811,217 - 23,814,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,147,974 - 1,148,927 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,147,654 - 1,149,722 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008975592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000051965   ⟹   ENSPPAP00000029117
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)Ensembl
RefSeq Acc Id: XM_008975592   ⟹   XP_008973840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBI
NHGRI_mPanPan11215,021,516 - 215,023,807 (+)NCBI
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBI
PanPan1.1111,825,072 - 11,827,452 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008973840 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000029117.1
RefSeq Acc Id: XP_008973840   ⟸   XM_008975592
- Sequence:
RefSeq Acc Id: ENSPPAP00000029117   ⟸   ENSPPAT00000051965


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051965.1 UniProtKB/TrEMBL
InterPro Natr_peptide UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/TrEMBL
  Natriuretic_peptide_atrial UniProtKB/TrEMBL
KEGG Report pps:100976028 UniProtKB/TrEMBL
NCBI Gene NPPA ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES A UniProtKB/TrEMBL
Pfam ANP UniProtKB/TrEMBL
PRINTS ANATPEPTIDE UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/TrEMBL
UniProt A0A2R9BL40_PANPA UniProtKB/TrEMBL