RGD Reference Report - Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats. - Rat Genome Database

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Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats.

Authors: Zhu, YB  Zhang, YB  Liu, DH  Li, XF  Liu, AJ  Fan, XM  Qiao, CH  Ling, F  Liu, YL 
Citation: Zhu YB, etal., Chin Med J (Engl). 2013 Feb;126(4):747-50.
RGD ID: 7247713
Pubmed: PMID:23422200   (View Abstract at PubMed)

BACKGROUND: An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities, including effects on endothelial function and inflammation. A recent study has revealed that ANP exerts anti-inflammatory effects. In this study we tested the effects of human ANP (hANP) on lung injury in a model of oleic acid (OA)-induced acute lung injury (ALI) in rats. METHODS: Rats were randomly assigned to three groups (n = 6 in each group). Rats in the control group received a 0.9% solution of NaCl (1 ml x kg(-1) x h(-1)) by continuous intravenous infusion, after 30 minutes a 0.9% solution of NaCl (1 ml/kg) was injected intravenously, and then the 0.9% NaCl infusion was restarted. Rats in the ALI group received a 0.9% NaCl solution (1 ml x kg(-1) x h(-1)) intravenous infusion, after 30 minutes OA was injected intravenously (0.1 ml/kg), and then the 0.9% NaCl infusion was restarted. Rats in the hANP-treated ALI group received a hANP (0.1 microg x kg(-1) x min(-1)) infusion, after 30 minutes OA was injected intravenously (0.1 ml/kg), and then the hANP infusion was restarted. The anti-inflammation effects of hANP were evaluated by histological examination and determination of serum cytokine levels. RESULTS: Serum interleukin (IL)-1beta, IL-6, IL-10 and tumor necrosis factor (TNF) alpha were increased in the ALI group at six hours. The levels of all factors were significantly lower in the hANP treated rats (P < 0.005). Similarly, levels of IL-1beta, IL-6, IL-10 and TNF-alpha were higher in the lung tissue in the ALI group at six hours. hANP treatment significantly reduced the levels of these factors in the lungs (P < 0.005). Histological examination revealed marked reduction in interstitial congestion, edema, and inflammation. CONCLUSION: hANP can attenuate inflammation in an OA-induced lung injury in rat model.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Acute Lung Injury  IDA 7247713 RGD 
Acute Lung Injury  ISONPPA (Homo sapiens)7247713; 7247713 RGD 
peritonitis  IDA 7247713 RGD 
peritonitis  ISONPPA (Homo sapiens)7247713; 7247713 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppa  (natriuretic peptide A)

Genes (Mus musculus)
Nppa  (natriuretic peptide type A)

Genes (Homo sapiens)
NPPA  (natriuretic peptide A)


Additional Information