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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737014
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases expressionEXP 6480464CTDbisphenol A results in increased expression of TLR4 mRNA; bisphenol A results in increased expression of TLR4 proteinPMID:30275377 PMID:31551929 PMID:32156529 PMID:32540565 PMID:33485121
Tlr4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Dietary Fats] results in increased expression of TLR4 proteinPMID:33265944
Tlr4affects bindingISOTLR4 (Homo sapiens)6480464CTDbisphenol A binds to [TLR4 protein binds to LY96 protein]PMID:33706241
Tlr4decreases expressionISOTlr4 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of TLR4 mRNAPMID:25181051
Tlr4increases expressionISOTlr4 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of TLR4 mRNA; bisphenol A results in increased expression of TLR4 proteinPMID:31551937 PMID:31661889 PMID:33296240
Tlr4increases expressionISOTLR4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of TLR4 mRNA; bisphenol A results in increased expression of TLR4 proteinPMID:32080224 PMID:33476716
Tlr4multiple interactionsISOTlr4 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of TLR4 mRNA; bisphenol A promotes the reaction [Fructose results in increased expression of TLR4 protein]; Fructose promotes the reaction [bisphenol A results in increased expression of TLR4 protein]PMID:26496021 PMID:31661889
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTDendotoxin, Escherichia coli promotes the reaction [bisphenol A results in increased expression of TLR4 protein]PMID:32080224
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