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GENE - TERM ANNOTATION REPORT

RGD ID: 2123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Acc ID: GO:0007026
Term: negative regulation of microtubule depolymerization
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
Definition Source(s): GOC:mah, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apcacts_upstream_of_or_withinISOApc (Mus musculus)1624291RGD PMID:16525027

PMID:16525027
Apcacts_upstream_of_or_withinISOAPC (Homo sapiens)1624291RGD PMID:17192415

PMID:17192415
Apcinvolved_inISOAPC (Homo sapiens)1624291RGD PMID:11166179

PMID:11166179
Apcinvolved_inIEAUniProtKB:P25054 or ensembl:ENSP000002574301600115EnsemblGO_REF:0000107

GO_REF:0000107
Apcinvolved_inIBAMGI:88039 or PANTHER:PTN000288612 or UniProtKB:P250541600115GO_CentralGO_REF:0000033

GO_REF:0000033
Apcinvolved_inISSUniProtKB:P250541600115UniProtGO_REF:0000024

GO_REF:0000024
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