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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2123
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apc
Name: APC regulator of WNT signaling pathway
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apcincreases expressionISOAPC (Homo sapiens)6480464CTDIndomethacin results in increased expression of APC mRNA; Indomethacin results in increased expression of APC proteinPMID:15963497
Apcmultiple interactionsISOApc (Mus musculus)6480464CTDIndomethacin inhibits the reaction [APC gene mutant form results in decreased expression of LPL mRNA]; Indomethacin inhibits the reaction [APC gene mutant form results in increased expression of TNF mRNA]PMID:17546600
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