GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Ursodeoxycholic Acid results in increased cleavage of PARP1 protein | PMID:21362627 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] | PMID:19728331 PMID:21362627 | | ||||||||||||||||||||||
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