GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | affects localization | ISO | H2AX (Homo sapiens) | 6480464 | CTD | hydroquinone affects the localization of H2AX protein modified form | PMID:20036648 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased expression of H2AX protein; hydroquinone results in increased expression of H2AX protein alternative form | PMID:21267443 PMID:22981619 PMID:26335980 PMID:26822515 PMID:27515134 PMID:28843007 PMID:35123993 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | hydroquinone results in increased expression of H2AX protein | PMID:22687461 PMID:23940708 | H2ax | increases phosphorylation | ISO | H2AX (Homo sapiens) | 6480464 | CTD | hydroquinone results in increased phosphorylation of H2AX protein | PMID:18835433 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of H2AX protein]; 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of H2AX protein]; [ABT-737 co-treated with hydroquinone] results in increased expression of H2AX protein; [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of H2AX protein modified form; [SIRT1 protein affects the susceptibility to hydroquinone] which affects the expression of H2AX protein; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of H2AX protein]; PARP1 protein affects the reaction [hydroquinone results in increased expression of H2AX protein]; POLH protein affects the reaction [hydroquinone results in increased expression of H2AX protein]; WRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AX protein alternative form]; WRN protein affects the reaction [hydroquinone results in increased expression of H2AX protein] | PMID:17875398 PMID:21267443 PMID:22981619 PMID:26822515 PMID:27515134 PMID:28843007 PMID:30506647 PMID:35123993 | H2ax | multiple interactions | ISO | H2ax (Mus musculus) | 6480464 | CTD | FAU protein affects the reaction [hydroquinone results in increased expression of H2AX protein] | PMID:22687461 | | ||||||||||||||||||||||
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