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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:de novo pyrimidine biosynthetic pathway
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Accession:PW:0000862 term browser browse the term
Definition:In the de novo biosynthetic pathway, pyrimidines are synthesized from simple precursors. Six reactions carried out by three enzymes in higher eukaryotes result in the formation of UMP, the precursor of all other pyrimidine nucleotides.
Synonyms:related_synonym: 'de novo' pyrimidine nucleobase biosynthetic process
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de novo pyrimidine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:15096496 RGD:5133412 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:12678497 RGD:5133414 NCBI chr 1:46,642,602...46,673,568 JBrowse link
G CMPK2 cytidine/uridine monophosphate kinase 2 ISO RGD PMID:192455 RGD:5133256 NCBI chr2A:6,856,242...6,874,567 JBrowse link
G CTPS1 CTP synthase 1 ISO RGD PMID:12678497 RGD:5133414 NCBI chr 1:40,275,581...40,308,421
Ensembl chr 1:41,592,509...41,624,455 		JBrowse link
G CTPS2 CTP synthase 2 ISO RGD PMID:20739275 RGD:5133419 NCBI chr  X:9,209,727...9,332,641
Ensembl chr  X:16,579,409...16,693,184 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO RGD PMID:15096496 RGD:5133412 NCBI chr16:52,977,879...52,994,496
Ensembl chr16:71,854,238...71,870,673 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO RGD PMID:11768308 RGD:5134680 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO RGD PMID:11768308 RGD:5134680 NCBI chr17:45,255,982...45,261,541 JBrowse link
G NME3 NME/NM23 nucleoside diphosphate kinase 3 ISO RGD PMID:11768308 RGD:5134680 NCBI chr16:392,694...394,106
Ensembl chr16:1,822,719...1,824,147 		JBrowse link
G NME4 NME/NM23 nucleoside diphosphate kinase 4 ISO RGD PMID:11768308 RGD:5134680 Ensembl chr16:389,068...393,976 JBrowse link
G NME6 NME/NM23 nucleoside diphosphate kinase 6 ISO RGD PMID:11768308 RGD:5134680 NCBI chr 3:48,206,365...48,217,618
Ensembl chr 3:49,290,069...49,299,831 		JBrowse link
G UMPS uridine monophosphate synthetase ISO RGD PMID:15096496 RGD:5133412 NCBI chr 3:121,832,758...121,851,707
Ensembl chr 3:128,731,355...128,745,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    classic metabolic pathway 1016
      nucleotide metabolic pathway 71
        pyrimidine metabolic pathway 31
          pyrimidine biosynthetic pathway 12
            de novo pyrimidine biosynthetic pathway 12
paths to the root