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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:pyruvate metabolic pathway
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Accession:PW:0000043 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, utilization and/or degradation of pyruvate - a salt, ester, or anionic form of pyruvic acid. Pyruvate, which is the end-product of glycolysis, can be converted to lactate under anaerobic conditions, can be further oxidized via the Krebs or citrate cycle or can be converted back to glucose via gluconeogenesis.
Synonyms:related_synonym: Pyruvate metabolism;   pyruvate metabolic process
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pyruvate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACACB acetyl-CoA carboxylase beta IEA KEGG hsa:00620 NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226 		JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr11:108,116,705...108,147,603
Ensembl chr11:108,116,695...108,147,603 		JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 IEA KEGG hsa:00620 NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112 		JBrowse link
G ACOT12 acyl-CoA thioesterase 12 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 5:81,308,609...81,394,134
Ensembl chr 5:81,329,996...81,394,179 		JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 IEA KEGG hsa:00620 NCBI chr20:25,006,237...25,058,139
Ensembl chr20:25,006,230...25,058,980 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
G ACYP1 acylphosphatase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr14:75,053,243...75,069,490
Ensembl chr14:75,053,237...75,069,483 		JBrowse link
G ACYP2 acylphosphatase 2 IEA KEGG hsa:00620 NCBI chr 2:53,971,113...54,305,300
Ensembl chr 2:53,970,838...54,305,300 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 IEA KEGG hsa:00620 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 IEA KEGG hsa:00620 NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760 		JBrowse link
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 IEA KEGG hsa:00620 NCBI chr 5:126,541,841...126,595,219
Ensembl chr 5:126,531,200...126,595,362 		JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 IEA KEGG hsa:00620 NCBI chr 1:165,662,216...165,698,562
Ensembl chr 1:165,662,216...165,698,562 		JBrowse link
G DLAT dihydrolipoamide S-acetyltransferase TAS
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:11795479 SMP:00060 hsa:00620, RGD:2307427 NCBI chr11:112,025,408...112,064,404
Ensembl chr11:112,025,033...112,064,404 		JBrowse link
G DLD dihydrolipoamide dehydrogenase TAS
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:11795479 SMP:00060 hsa:00620, RGD:2307427 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730 		JBrowse link
G GLO1 glyoxalase I IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GRHPR glyoxylate and hydroxypyruvate reductase IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 9:37,422,435...37,439,494
Ensembl chr 9:37,422,666...37,436,990 		JBrowse link
G HAGH hydroxyacylglutathione hydrolase IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157 		JBrowse link
G HAGHL hydroxyacylglutathione hydrolase like IEA KEGG hsa:00620 NCBI chr16:727,106...729,715
Ensembl chr16:726,936...735,525 		JBrowse link
G LDHA lactate dehydrogenase A IEA KEGG hsa:00620 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G LDHAL6A lactate dehydrogenase A like 6A IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr11:18,455,856...18,479,601
Ensembl chr11:18,455,824...18,479,601 		JBrowse link
G LDHAL6B lactate dehydrogenase A like 6B IEA KEGG hsa:00620 NCBI chr15:59,206,843...59,208,588
Ensembl chr15:59,206,843...59,208,588 		JBrowse link
G LDHB lactate dehydrogenase B IEA KEGG hsa:00620 NCBI chr12:21,635,342...21,657,842
Ensembl chr12:21,635,342...21,757,857 		JBrowse link
G LDHC lactate dehydrogenase C IEA KEGG hsa:00620 NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063 		JBrowse link
G LDHD lactate dehydrogenase D IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr16:75,111,864...75,116,780
Ensembl chr16:75,111,860...75,116,780 		JBrowse link
G MDH1 malate dehydrogenase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197 		JBrowse link
G MDH2 malate dehydrogenase 2 IEA KEGG hsa:00620 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508 		JBrowse link
G ME1 malic enzyme 1 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G ME2 malic enzyme 2 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr18:50,879,118...50,954,257
Ensembl chr18:50,879,080...50,954,257 		JBrowse link
G ME3 malic enzyme 3 IEA KEGG hsa:00620 NCBI chr11:86,434,930...86,672,616
Ensembl chr11:86,441,108...86,672,636 		JBrowse link
G PC pyruvate carboxylase IEA
EXP
ISO		 KEGG
SMPDB
RGD		 PMID:15507531 SMP:00060 hsa:00620, RGD:1601554 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 IEA
EXP		 KEGG
SMPDB		 SMP:00060 hsa:00620 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial IEA KEGG hsa:00620 NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 IEA
EXP
TAS		 KEGG
SMPDB
RGD		 PMID:11795479 SMP:00060 hsa:00620, RGD:2307427 NCBI chr  X:19,343,927...19,361,718
Ensembl chr  X:19,343,893...19,361,718 		JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 TAS
IEA		 KEGG
RGD		 PMID:11795479 hsa:00620, RGD:2307427 NCBI chr 4:95,840,093...95,841,464
Ensembl chr 4:95,840,093...95,841,464 		JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta TAS
EXP
IEA		 SMPDB
KEGG
RGD		 PMID:11795479 SMP:00060 hsa:00620, RGD:2307427 NCBI chr 3:58,427,630...58,433,832
Ensembl chr 3:58,427,630...58,433,857 		JBrowse link
G PDHX pyruvate dehydrogenase complex component X TAS RGD PMID:11795479 RGD:2307427 NCBI chr11:34,915,920...34,996,128
Ensembl chr11:34,915,829...35,020,591 		JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 TAS RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669 		JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 TAS RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152 		JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 TAS RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,244...24,550,466 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 TAS RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
G PDP1 pyruvate dehydrogenase phosphatase catalytic subunit 1 TAS RGD PMID:17310282 RGD:2307428 NCBI chr 8:93,916,923...93,926,068
Ensembl chr 8:93,857,807...93,926,068 		JBrowse link
G PDP2 pyruvate dehydrogenase phosphatase catalytic subunit 2 TAS RGD PMID:17310282 RGD:2307428 NCBI chr16:66,880,515...66,891,101
Ensembl chr16:66,878,589...66,895,754 		JBrowse link
G PKLR pyruvate kinase L/R IEA
EXP
ISO		 KEGG
SMPDB
RGD		 PMID:4273555 SMP:00060 hsa:00620, RGD:2302790 NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438 		JBrowse link
G PKM pyruvate kinase M1/2 ISO RGD PMID:4273555 RGD:2302790 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5958
    classic metabolic pathway 1803
      carbohydrate metabolic pathway 540
        pyruvate metabolic pathway 47
Path 2
Term Annotations click to browse term
  pathway 5958
    regulatory pathway 3604
      homeostasis pathway 1667
        glucose homeostasis pathway 347
          glucose utilization pathway 120
            glucose oxidation pathway 100
              pyruvate metabolic pathway 47
paths to the root