Gene: AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase))  Homo sapiens
Symbol: AKR1B1
Name: aldo-keto reductase family 1, member B1 (aldose reductase)
Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADR; aldehyde reductase 1; aldehyde reductase 1 (low km aldose reductase) (5.8 kb psti fragment, probably the functional gene); aldo-keto reductase family 1 member B1; aldose reductase; ALDR1; ALR2; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase; MGC1804; OTTHUMP00000207727; OTTHUMP00000207728
Orthologs: Mus musculus : Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase))  MGI
Rattus norvegicus : Akr1b1 (aldo-keto reductase family 1, member B1 (aldose reductase))
Related Pseudogenes: AKR1B1P1   AKR1B1P2   AKR1B1P3   AKR1B1P4   AKR1B1P5   AKR1B1P6   AKR1B1P7   AKR1B1P8  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_17137,491,281 - 137,508,059-NCBI
Human Alternate Assembly CRA_TCAGchr7v27133,471,421 - 133,488,201-NCBI
Human Genome Assembly HuRef7128,428,754 - 128,445,534-NCBI
Human Genome Assembly GRCh377134,127,107 - 134,143,888-NCBI
Human Genome Assembly Build 367133,777,647 - 133,794,428-NCBI
Human Cytogenetic Map7q35 NCBI
Human Genome Assembly7133,584,361 - 133,601,143 NCBI
Model

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Sequence

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Nomenclature History
  
More on AKR1B1
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 732178
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-02-27
Status: ACTIVE



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