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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:potassium channel inhibitors pharmacodynamics pathway
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Accession:PW:0000725 term browser browse the term
Definition:The pathway of anti-diabetic drugs-target interaction and of the biochemical or physiological responses to them. Repaglinide, nateglinide and sulfonylurea are used as inhibitors of ATP-dependent potassium channel. By blocking the channel they stimulate insulin secretion to lower blood glucose level. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00453;   SMP:00454
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potassium channel inhibitors pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO SMPDB SMP:00453 SMP:00454 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00453 SMP:00454 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00453 SMP:00454 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00453 SMP:00454 NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694 		JBrowse link
G Ins2 insulin 2 ISO SMPDB SMP:00453 SMP:00454 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO SMPDB SMP:00453 SMP:00454 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
Term paths to the root
Path 1
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  pathway 6091
    drug pathway 397
      alimentary tract and metabolism drug pathway 80
        anti-diabetic drug pathway 14
          potassium channel inhibitors pharmacodynamics pathway 6
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