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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nuclear factor, erythroid 2 like 2 signaling pathway
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Accession:PW:0000369 term browser browse the term
Definition:Nuclear factor, 2 like 2 (Nfe2l2, also known as Nrf2) signaling pathway is one of the most important regulator of antioxidant and/or electrophilic stress responses. Upon activation, Nfe2l2 induces the expression of antioxidant, xenobiotic metabolism, and cytoprotective genes, among others. Deregulation of the pathway has been associated with various conditions, including neurodegeneration and cancer.
Synonyms:exact_synonym: Nrf2 signaling pathway
 related_synonym: Nfe2l2 signaling pathway
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nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA1 BRCA1 DNA repair associated ISO RGD PMID:24647116 RGD:11535066 NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:24647116 PMID:25937177 RGD:11535066 RGD:11535070 NCBI chr10:97,958,527...98,159,550
Ensembl chr10:101,431,318...101,632,496 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO RGD PMID:24647116 RGD:11535066 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CHD6 chromodomain helicase DNA binding protein 6 ISO RGD PMID:24647116 RGD:11535066 NCBI chr20:37,744,012...37,953,593
Ensembl chr20:38,839,685...38,999,501 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:24647116 RGD:11535066 NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206 		JBrowse link
G CUL1 cullin 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:140,428,442...140,531,136
Ensembl chr 7:152,908,303...153,011,254 		JBrowse link
G CUL3 cullin 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr2B:111,714,533...111,827,080
Ensembl chr2B:230,289,195...230,378,991 		JBrowse link
G DPP3 dipeptidyl peptidase 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr11:61,836,463...61,867,303
Ensembl chr11:65,161,892...65,191,398 		JBrowse link
G GADD45GIP1 GADD45G interacting protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr19:12,516,581...12,519,673
Ensembl chr19:13,259,047...13,262,044 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha ISO RGD PMID:25937177 RGD:11535070 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:25937177 RGD:11535070 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:24647116 RGD:11535066 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 ISO RGD PMID:11439354 PMID:20026152 PMID:24647116 PMID:26419687 RGD:11530066 RGD:11535066 RGD:6902900 RGD:727319 NCBI chr19:10,037,544...10,055,091
Ensembl chr19:10,701,303...10,717,604 		JBrowse link
G MAFF MAF bZIP transcription factor F ISO RGD PMID:24647116 RGD:11535066 NCBI chr22:19,114,929...19,129,901 JBrowse link
G MAFG MAF bZIP transcription factor G ISO RGD PMID:24647116 RGD:11535066 NCBI chr17:76,323,874...76,333,300
Ensembl chr17:82,030,699...82,031,278 		JBrowse link
G MAFK MAF bZIP transcription factor K ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:1,778,862...1,791,163
Ensembl chr 7:1,904,031...1,909,774 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr20:43,838,227...43,992,407
Ensembl chr20:45,000,422...45,073,549 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:24647116 PMID:25937177 PMID:26419687 RGD:11530066 RGD:11535066 RGD:11535070 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:31432116 PMID:31889292 RGD:21201308 RGD:25823187 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G PALB2 partner and localizer of BRCA2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117 		JBrowse link
G PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:24647116 RGD:11535066
G PTEN phosphatase and tensin homolog ISO RGD PMID:25937177 RGD:11535070 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G RBX1 ring-box 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175 		JBrowse link
G RNF4 ring finger protein 4 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 4:2,614,918...2,661,785
Ensembl chr 4:2,540,612...2,563,937 		JBrowse link
G SIAH2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:147,759,375...147,781,639
Ensembl chr 3:155,332,751...155,354,139 		JBrowse link
G SKP1 S-phase kinase associated protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 5:129,560,086...129,580,188
Ensembl chr 5:135,713,085...135,729,653 		JBrowse link
G SQSTM1 sequestosome 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4069
    regulatory pathway 2518
      cellular detoxification pathway 73
        nuclear factor, erythroid 2 like 2 signaling pathway 27
          altered nuclear factor, erythroid 2 like 2 signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4069
    regulatory pathway 2518
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1352
        transcription pathway 941
          transcription pathway via transcription factor mediated signaling 374
            nuclear factor, erythroid 2 like 2 signaling pathway 27
              altered nuclear factor, erythroid 2 like 2 signaling pathway 0
paths to the root