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Pathways
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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
aldosterone signaling pathway   
altered cellular detoxification pathway +  
altered oxidative stress response pathway 
altered transcription factor mediated signaling pathway +    
altered transcription pathway via transcription factor mediated signaling +    
androgen signaling pathway +     
aryl hydrocarbon receptor signaling pathway  
arylamine metabolic pathway 
basic helix-loop-helix signaling pathway +    
bile acid signaling pathway  
cortisol signaling pathway +    
endogenous antioxidant pathway +  
estrogen signaling pathway +    
forkhead signaling pathway +   
glutathione conjugation pathway +   
hypoxia inducible factor pathway +     
nuclear factor kappa B signaling pathway +    
nuclear factor of activated T-cells signaling pathway  
nuclear factor, erythroid 2 like 2 signaling pathway +    
Nuclear factor, 2 like 2 (Nfe2l2, also known as Nrf2) signaling pathway is one of the most important regulator of antioxidant and/or electrophilic stress responses. Upon activation, Nfe2l2 induces the expression of antioxidant, xenobiotic metabolism, and cytoprotective genes, among others. Deregulation of the pathway has been associated with various conditions, including neurodegeneration and cancer.
View Interactive Diagram
p53 signaling pathway +     
peroxisome proliferator-activated receptor signaling pathway +  
phase I biotransformation pathway +   
phase II biotransformation pathway +   
polycyclic aromatic hydrocarbon metabolic pathway +  
retinoic acid signaling pathway   
sterol regulatory element-binding protein signaling pathway   
toxin and toxicant response pathway +    
transport pathway for the elimination of drugs, endogenous or exogenous compounds and metabolites +   
vitamin D signaling pathway 
xenobiotics biodegradation pathway +  

Synonyms
Exact Synonyms: Nrf2 signaling pathway
Related Synonyms: Nfe2l2 signaling pathway
Definition Sources: PMID:15252150, PMID:20486759, PMID:20815789, PMID:22874821, PMID:26122708

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