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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:cellular detoxification pathway
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Accession:PW:0000124 term browser browse the term
Definition:A pathway triggered by exogenous or endogenous elements, compounds or molecules that can be harmful to the system. The phase I (oxidative) and phase II (conjugative) metabolizing enzymes and the phase III transport systems and other pathways are involved in the response mechanisms resulting in processing and subsequent elimination of such elements. Others induce downstream effects such as antioxidant, cell death or inflammatory response pathways.
Synonyms:related_synonym: cellular detoxification


show annotations for term's descendants           Sort by:
aryl hydrocarbon receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor ISO RGD PMID:10639156 RGD:1300277 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator ISO RGD PMID:1317062 RGD:41410437 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 TAS RGD PMID:12859947 RGD:631760 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153 		JBrowse link
bisphenol A response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 ISO RGD PMID:22927406 PMID:24382480 RGD:8547944, RGD:8548497 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:22927406 PMID:24382480 RGD:8547944, RGD:8548497 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:22927406 PMID:24382480 RGD:8547944, RGD:8548497 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
cerium oxide nanoparticle response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:23478040 RGD:7364779 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:23478040 RGD:7364779 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
cisplatin response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 ISO RGD PMID:24278698 RGD:8548480 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 TAS RGD PMID:24278698 RGD:8548480 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO
IDA		 RGD PMID:24278698 PMID:23123662 RGD:8548480, RGD:8549769 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 ISO RGD PMID:24278698 RGD:8548480 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
doxorubicin response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 ISO RGD PMID:15883202 PMID:24616701 RGD:10395266, RGD:10395265 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO RGD PMID:15883202 PMID:24616701 RGD:10395266, RGD:10395265 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Top2b DNA topoisomerase II beta ISO RGD PMID:25895646 PMID:24361676 RGD:10395260, RGD:10395267 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
glutathione conjugation pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 ISS
IDA		 RGD PMID:10720752 PMID:17197701 RGD:1358120, RGD:1641938 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 ISS
IDA		 RGD PMID:10720752 PMID:17197701 RGD:1358120, RGD:1641938 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 ISO
IDA		 RGD PMID:10720752 PMID:11018474 RGD:1358120, RGD:1641942 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 IAGP RGD PMID:12624007 RGD:631154 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstm5l glutathione S-transferase, mu 5-like ISS RGD PMID:14576844 RGD:1358122 NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 TAS RGD PMID:10720752 RGD:1358120 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 ISO RGD PMID:10720752 RGD:1358120 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IDA RGD PMID:15110098 PMID:11018474 RGD:1357965, RGD:1641942 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISS RGD PMID:10720752 RGD:1358120 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 ISS RGD PMID:10720752 RGD:1358120 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
multidrug resistance protein mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
multidrug resistance-associated protein mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 ISS RGD PMID:12433976 RGD:1358123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 ISO RGD PMID:12433976 RGD:1358123 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc12 ATP binding cassette subfamily C member 12 ISS RGD PMID:12801629 RGD:1302885 NCBI chr19:20,549,298...20,621,991
Ensembl chr19:20,549,405...20,620,734 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:11557524 RGD:70559 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISS RGD PMID:12433976 RGD:1358123 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 ISS RGD PMID:12433976 RGD:1358123 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 IDA RGD PMID:10893247 RGD:632215 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
multispecific organic anion transporter mediated transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 IDA RGD PMID:9228014 RGD:68822 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 IDA RGD PMID:9650585 RGD:70525 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 IDA RGD PMID:12006354 RGD:625763 NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:174,876,593...174,950,873 		JBrowse link
G Slco1a3 solute carrier organic anion transporter family member 1A3 IDA RGD PMID:8702823 RGD:729732 NCBI chr 4:174,975,119...175,018,640
Ensembl chr 4:174,975,122...175,014,586 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 ISS RGD PMID:9294213 RGD:729806 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1A5 TAS RGD PMID:11867608 RGD:70527 NCBI chr 4:175,172,390...175,254,598
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 ISS RGD PMID:12433976 RGD:1358123 NCBI chr 4:175,072,143...175,107,950
Ensembl chr 4:175,072,143...175,117,263 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 IDA RGD PMID:10838093 RGD:68850 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 IDA RGD PMID:11981753 RGD:634158 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 TAS RGD PMID:11316767 RGD:727314 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305 		JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 IDA RGD PMID:14993604 RGD:1303977 NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715 		JBrowse link
nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:24647116 PMID:25937177 RGD:11535066, RGD:11535070 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:24647116 RGD:11535066 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:149,596,509...149,757,765
Ensembl chr 3:149,596,509...149,757,755 		JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cul1 cullin 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Cul3 cullin 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dpp3 dipeptidylpeptidase 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Gadd45gip1 GADD45G interacting protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:25937177 RGD:11535070 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:24647116 RGD:11535066 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 IMP
ISO
IDA		 RGD PMID:11439354 PMID:24647116 PMID:26419687 PMID:20026152 RGD:727319, RGD:11535066, RGD:11530066, RGD:6902900 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Maff MAF bZIP transcription factor F ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafg MAF bZIP transcription factor G ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mafk MAF bZIP transcription factor K ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:26419687 PMID:25937177 PMID:24647116 RGD:11530066, RGD:11535070, RGD:11535066 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IEP RGD PMID:31889292 PMID:31432116 RGD:21201308, RGD:25823187 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Palb2 partner and localizer of BRCA2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:24647116 RGD:11535066 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:25937177 RGD:11535070 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rbx1 ring-box 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rnf4 ring finger protein 4 ISO RGD PMID:24647116 RGD:11535066 NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 ISO RGD PMID:24647116 RGD:11535066 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Sqstm1 sequestosome 1 ISO RGD PMID:24647116 RGD:11535066 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
organophosphate response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:24508992 RGD:8551790 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin ISO RGD PMID:23261756 RGD:8551793 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO RGD PMID:22155227 RGD:8551791 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Pon1 paraoxonase 1 ISO RGD PMID:19433263 RGD:8551792 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
paracetamol response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO RGD PMID:22998987 RGD:8552696 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
phase I biotransformation pathway via cytochrome P450 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide IEA KEGG rno:00980 rno:00982 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 IEA KEGG rno:00980 rno:00982 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 IEA KEGG rno:00980 rno:00982 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921 		JBrowse link
G Aox1 aldehyde oxidase 1 IEA KEGG rno:00982 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Aox2 aldehyde oxidase 2 IEA KEGG rno:00982 NCBI chr 9:59,828,403...59,916,175
Ensembl chr 9:59,828,084...59,916,146 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA
IEA		 KEGG
RGD		 PMID:12464257 rno:00980, RGD:727674 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 IDA
IEA		 KEGG
RGD		 PMID:6772643 rno:00980 rno:00982, RGD:151347456 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 IEP
IEA		 KEGG
RGD		 PMID:7744798 rno:00980, RGD:728267 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 IEP
IEA		 KEGG
RGD		 PMID:3818621 rno:00982, RGD:70704 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00982, RGD:1357962 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 IDA
IEA		 KEGG
RGD		 PMID:12167220 rno:00982, RGD:1298847 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00980 rno:00982, RGD:1300401 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 IEA KEGG rno:00980 rno:00982 NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00980 rno:00982, RGD:1357962 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 IEA KEGG rno:00980 rno:00982 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 IEA KEGG rno:00980 rno:00982 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 NAS
IEA		 KEGG
RGD		 PMID:10879814 rno:00980 rno:00982, RGD:1357962 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 IEA KEGG rno:00980 rno:00982 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 IEA KEGG rno:00980 rno:00982 NCBI chr 1:242,889,218...242,913,869
Ensembl chr 1:242,889,224...242,913,858 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 IEA KEGG rno:00980 rno:00982 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 NAS
IEA		 KEGG
RGD		 PMID:14523622 rno:00982, RGD:1300401 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 IEA KEGG rno:00982 NCBI chr 7:113,899,905...113,904,458
Ensembl chr 7:113,899,890...113,904,495 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 IEA KEGG rno:00980 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 IEA KEGG rno:00980 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 IEA KEGG rno:00980 rno:00982 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 IEA KEGG rno:00980 rno:00982 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 IEA KEGG rno:00980 rno:00982 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 IEA KEGG rno:00980 rno:00982 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 IDA
IMP		 RGD PMID:8248926 PMID:9310344 RGD:1626415, RGD:1626420 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Dhdh dihydrodiol dehydrogenase IEA KEGG rno:00980 NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197 		JBrowse link
G Ephx1 epoxide hydrolase 1 IEA KEGG rno:00980 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 IEA KEGG rno:00982 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 IEA KEGG rno:00982 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 IEA KEGG rno:00982 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 IEA KEGG rno:00982 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 IEA KEGG rno:00982 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 IEA KEGG rno:00980 rno:00982 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta3l1 glutathione S-transferase alpha 3 like 1 IEA KEGG rno:00980 rno:00982 NCBI chr 9:23,619,691...23,628,517
Ensembl chr 9:23,620,010...23,632,333 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 IEA KEGG rno:00980 rno:00982 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 IEA KEGG rno:00980 rno:00982 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,590,450...195,612,578
Ensembl chr 2:195,607,289...195,612,475 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstm6 glutathione S-transferase, mu 6 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,579,566...195,584,340
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA KEGG rno:00980 rno:00982 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 IEA KEGG rno:00980 rno:00982 NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEA KEGG rno:00980 rno:00982 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 IEA KEGG rno:00980 rno:00982 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 IEA KEGG rno:00980 rno:00982 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 IEA KEGG rno:00980 rno:00982 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Maoa monoamine oxidase A IEA KEGG rno:00982 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B IEA KEGG rno:00982 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 IEA KEGG rno:00980 rno:00982 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 IEA KEGG rno:00980 rno:00982 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 IEA KEGG rno:00980 rno:00982 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 IEA KEGG rno:00980 rno:00982 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B IEA KEGG rno:00980 rno:00982 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 IEA KEGG rno:00980 rno:00982 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 IEA KEGG rno:00980 rno:00982 NCBI chr14:20,817,285...20,833,917
Ensembl chr14:20,817,285...20,833,917 		JBrowse link
titanium dioxide nanoparticle response pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:22614867 PMID:22419868 RGD:7248687, RGD:7248688 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:22614867 PMID:22419868 RGD:7248687, RGD:7248688 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 ISO RGD PMID:22419868 RGD:7248688 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:22419868 RGD:7248688 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:23803652 RGD:7248686 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:22614867 RGD:7248687 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root