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ONTOLOGY REPORT - ANNOTATIONS

Term:mechanosensitive monoatomic cation channel activity
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Accession:GO:0140135 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress.
Synonyms:exact_synonym: mechanically-gated cation channel activity
 broad_synonym: mechanosensitive cation channel activity
 xref: Reactome:R-HSA-9659380 "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell";   Reactome:R-HSA-9663363 "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell"


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mechanosensitive monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Piezo1 piezo-type mechanosensitive ion channel component 1 enables IEA
ISO		 GO_REF:0000107
(PMID:25955826)
(PMID:32142647)		 Ensembl
RGD		 PMID:25955826 PMID:32142647 GO_REF:0000107 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Tmem63b transmembrane protein 63B enables ISO (PMID:38127458) RGD PMID:38127458 NCBI chr 9:15,313,867...15,340,722
Ensembl chr 9:15,320,432...15,340,720 		JBrowse link
mechanosensitive potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk4 potassium two pore domain channel subfamily K member 4 enables IDA
ISO		 PMID:15677687
(PMID:22282805)		 RGD PMID:22282805 PMID:15677687 RGD:10047327 NCBI chr 1:204,117,941...204,129,494
Ensembl chr 1:204,114,572...204,125,925 		JBrowse link
G Tmem87a transmembrane protein 87A NOT|enables ISO (PMID:36373655) RGD PMID:36373655 NCBI chr 3:107,307,726...107,353,571
Ensembl chr 3:107,307,726...107,353,551 		JBrowse link
stretch-activated, monoatomic cation-selective, calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nalf1 NALCN channel auxiliary factor 1 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr16:79,713,577...80,236,295
Ensembl chr16:79,713,724...80,235,120 		JBrowse link
G Nalf2 NALCN channel auxiliary factor 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:64,925,100...64,951,074
Ensembl chr  X:64,925,051...64,951,077 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 enables ISO (PMID:23136043) RGD PMID:23136043 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        monoatomic ion transmembrane transporter activity 752
          monoatomic ion channel activity 457
            monoatomic cation channel activity 347
              mechanosensitive monoatomic cation channel activity 7
                mechanosensitive potassium channel activity 2
                mechanosensitive voltage-gated sodium channel activity 0
                stretch-activated, monoatomic cation-selective, calcium channel activity + 3
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        passive transmembrane transporter activity 519
          channel activity 519
            monoatomic ion channel activity 457
              mechanosensitive monoatomic ion channel activity 18
                mechanosensitive monoatomic cation channel activity 7
                  mechanosensitive potassium channel activity 2
                  mechanosensitive voltage-gated sodium channel activity 0
                  stretch-activated, monoatomic cation-selective, calcium channel activity + 3
paths to the root