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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acyl-CoA hydrolase activity
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Accession:GO:0047617 term browser browse the term
Definition:Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
Synonyms:exact_synonym: acyl-CoA thioesterase activity;   acyl-CoA thiolesterase activity
 narrow_synonym: acyl-CoA thioesterase I activity;   acyl-CoA thioesterase II activity
 broad_synonym: acyl-CoA hydrolase activity
 related_synonym: acyl coenzyme A hydrolase activity;   acyl coenzyme A thioesterase activity;   thioesterase B;   thioesterase II
 alt_id: GO:0008778;   GO:0016291;   GO:0016292
 xref: EC:3.1.2.20;   EC:3.1.2.3;   MetaCyc:ACYL-COA-HYDROLASE-RXN;   RHEA:16781;   reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA";   reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA";   reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA"


show annotations for term's descendants           Sort by:
fatty acyl-CoA hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 enables ISO
ISS		 (PMID:29397936), (PMID:33500543)
GO_REF:0000024		 RGD
UniProt		 PMID:29397936 PMID:33500543 GO_REF:0000024 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 enables ISO
ISS		 (PMID:29397936)
GO_REF:0000024		 RGD
UniProt		 PMID:29397936 GO_REF:0000024 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 enables ISO
ISS		 (PMID:29397936)
GO_REF:0000024		 RGD
UniProt		 PMID:29397936 GO_REF:0000024 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 enables IEA
ISO
IDA		 GO_REF:0000107
(PMID:25478839)
PMID:16476568		 Ensembl
RGD		 PMID:25478839 PMID:16476568 GO_REF:0000107, RGD:2317620 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acnat1 acyl-coenzyme A amino acid N-acyltransferase 1 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:63,796,651...63,801,601
Ensembl chr 5:63,764,666...63,786,144
Ensembl chr 5:63,764,666...63,786,144 		JBrowse link
G Acnat2 acyl-coenzyme A amino acid N-acyltransferase 2 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:63,753,269...63,757,521
Ensembl chr 5:63,753,270...63,757,521 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 enables IDA
ISO
IEA
IBA		 (PMID:11694534)
GO_REF:0000118
GO_REF:0000033
PMID:7906114
(PMID:16940157)		 RGD
TreeGrafter
GO_Central		 PMID:11694534 PMID:16940157 PMID:9490035 PMID:7906114 GO_REF:0000033 GO_REF:0000118, RGD:70703, RGD:14390064 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot11 acyl-CoA thioesterase 11 enables ISO (PMID:22897136) RGD PMID:22897136 NCBI chr 5:121,523,833...121,581,699
Ensembl chr 5:121,527,435...121,581,538 		JBrowse link
G Acot12 acyl-CoA thioesterase 12 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536 		JBrowse link
G Acot13 acyl-CoA thioesterase 13 enables ISO
IBA		 (PMID:16934754), (PMID:19170545)
GO_REF:0000033		 RGD
GO_Central		 PMID:16934754 PMID:19170545 GO_REF:0000033 NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 enables IDA
IEA
IBA
ISO		 GO_REF:0000118
GO_REF:0000033
(PMID:10944470), (PMID:16940157)		 TreeGrafter
GO_Central
RGD		 PMID:10944470 PMID:16940157 PMID:9445388 GO_REF:0000033 GO_REF:0000118, RGD:727625 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 enables IBA
ISO		 GO_REF:0000033
(MGI:3663233|PMID:16940157), (PMID:15007068)		 GO_Central
RGD		 PMID:15007068 PMID:16940157 GO_REF:0000033 MGI:3663233 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 enables ISO
IBA		 (PMID:16141203), (PMID:16940157)
GO_REF:0000033
(MGI:3663233|PMID:16940157)		 RGD
GO_Central		 PMID:16141203 PMID:16940157 GO_REF:0000033 MGI:3663233 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917 		JBrowse link
G Acot5 acyl-CoA thioesterase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:103,701,908...103,708,696
Ensembl chr 6:103,701,908...103,708,696 		JBrowse link
G Acot6 acyl-CoA thioesterase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446 		JBrowse link
G Acot7 acyl-CoA thioesterase 7 enables IDA
IEA		 GO_REF:0000118 TreeGrafter
RGD		 PMID:9125130 GO_REF:0000118, RGD:724609 NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309 		JBrowse link
G Acot8 acyl-CoA thioesterase 8 enables ISO
IBA
IDA		 (PMID:10092594), (PMID:15194431)
(PMID:11673457)
GO_REF:0000033
PMID:11785945		 RGD
GO_Central		 PMID:10092594 PMID:11673457 PMID:15194431 PMID:11785945 GO_REF:0000033, RGD:70235 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 enables IBA
ISO		 GO_REF:0000033
(MGI:6718236|PMID:23864032), (PMID:10383425)		 GO_Central
RGD		 PMID:10383425 PMID:23864032 GO_REF:0000033 MGI:6718236 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Acsbg2 acyl-CoA synthetase bubblegum family member 2 enables ISO (PMID:16762313) RGD PMID:16762313 NCBI chr 9:1,683,846...1,715,517
Ensembl chr 9:1,683,847...1,714,518 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Them7 thioesterase superfamily member 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:91,666,144...91,834,783
Ensembl chr 3:91,666,152...91,834,783 		JBrowse link
long-chain fatty acyl-CoA hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot11 acyl-CoA thioesterase 11 enables ISO
IBA		 (PMID:22897136)
GO_REF:0000033		 RGD
GO_Central		 PMID:22897136 GO_REF:0000033 NCBI chr 5:121,523,833...121,581,699
Ensembl chr 5:121,527,435...121,581,538 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 IDA RGD PMID:7744868 RGD:2315867 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acot7 acyl-CoA thioesterase 7 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:11834298)
(PMID:10578051)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:10578051 PMID:11834298 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309 		JBrowse link
G Acot8 acyl-CoA thioesterase 8 NOT|enables ISO
ISS
IEA		 (PMID:9153233)
(PMID:9299485)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:9153233 PMID:9299485 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 enables ISO (MGI:6718236|PMID:23864032) RGD PMID:23864032 MGI:6718236 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase enables ISO (PMID:12810727) RGD PMID:12810727 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein enables ISO (PMID:35427157)
(MGI:7266015|PMID:35427157)		 RGD PMID:35427157 MGI:7266015 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Desi1 desumoylating isopeptidase 1 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:35427157)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:35427157 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:113,519,974...113,542,834
Ensembl chr 7:113,519,980...113,542,845 		JBrowse link
G Desi2 desumoylating isopeptidase 2 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:35427157)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:35427157 GO_REF:0000024 GO_REF:0000107 NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IDA RGD PMID:15870076 RGD:1625002 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Mblac2 metallo-beta-lactamase domain containing 2 enables IEA
ISO		 GO_REF:0000107
(PMID:33219126)		 Ensembl
RGD		 PMID:33219126 GO_REF:0000107 NCBI chr 2:11,986,075...12,028,882
Ensembl chr 2:11,986,027...12,030,950 		JBrowse link
G Pla2g6 phospholipase A2 group VI enables IDA
IBA
ISO
ISS
IEA		 PMID:18937505
GO_REF:0000033
(MGI:3831205|PMID:18937505)
(PMID:20886109)
GO_REF:0000024
GO_REF:0000107		 GO_Central
RGD
UniProt
Ensembl		 PMID:18937505 PMID:20886109 PMID:18937505 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3831205, RGD:25671384 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 enables ISS
ISO		 GO_REF:0000024
(PMID:10658183)
PMID:8895569		 UniProt
RGD		 PMID:10658183 PMID:8895569 GO_REF:0000024, RGD:8553248 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Them4 thioesterase superfamily member 4 enables ISS
ISO		 GO_REF:0000024
(PMID:22871024)		 UniProt
RGD		 PMID:22871024 GO_REF:0000024 NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708 		JBrowse link
G Them5 thioesterase superfamily member 5 enables IBA
ISO		 GO_REF:0000033
(PMID:22586271)		 GO_Central
RGD		 PMID:22586271 GO_REF:0000033 NCBI chr 2:181,980,783...181,986,002
Ensembl chr 2:181,980,783...181,986,002 		JBrowse link
medium-chain fatty acyl-CoA hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot8 acyl-CoA thioesterase 8 enables ISO
ISS
IEA		 (PMID:9153233), (PMID:9299485)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:9153233 PMID:9299485 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase enables ISO (PMID:12810727) RGD PMID:12810727 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
very long-chain fatty acyl-CoA hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase enables ISO (PMID:12810727) RGD PMID:12810727 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      hydrolase activity 2639
        hydrolase activity, acting on ester bonds 837
          thiolester hydrolase activity 51
            acyl-CoA hydrolase activity 30
              fatty acyl-CoA hydrolase activity 30
                long-chain fatty acyl-CoA hydrolase activity 15
                medium-chain fatty acyl-CoA hydrolase activity 2
                short-chain fatty acyl-CoA hydrolase activity 0
                very long-chain fatty acyl-CoA hydrolase activity 2
paths to the root