Acnat1 (acyl-coenzyme A amino acid N-acyltransferase 1) - Rat Genome Database

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Gene: Acnat1 (acyl-coenzyme A amino acid N-acyltransferase 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Acnat1
Name: acyl-coenzyme A amino acid N-acyltransferase 1
RGD ID: 1584701
Description: Predicted to enable thiolester hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acyl-coenzyme A amino acid N-acyltransferase 2-like; LOC681043; similar to bile acid Coenzyme A: amino acid N-acyltransferase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,589,330 - 68,597,167 (-)NCBIGRCr8
mRatBN7.2563,796,651 - 63,801,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl563,796,430 - 63,838,293 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl563,764,666 - 63,786,144 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0564,710,885 - 64,718,500 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,713,443 - 64,718,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,171,678 - 69,174,736 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,189,979 - 66,195,170 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera563,806,222 - 63,813,838 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
peroxisome  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Acnat1
76 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56319089069927503Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 7 7 7
Low 32 32 32 1 15
Below cutoff 5 1 3 1 17 21 20 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078547   ⟹   ENSRNOP00000069395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl563,796,430 - 63,801,289 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088211   ⟹   ENSRNOP00000072246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl563,764,666 - 63,786,144 (-)Ensembl
Rnor_6.0 Ensembl564,713,443 - 64,718,131 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100761   ⟹   ENSRNOP00000092600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl563,796,430 - 63,838,293 (-)Ensembl
RefSeq Acc Id: XM_008763718   ⟹   XP_008761940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8568,589,330 - 68,597,167 (-)NCBI
mRatBN7.2563,796,651 - 63,801,601 (-)NCBI
Rnor_6.0564,710,885 - 64,718,500 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008761940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069269.2
  ENSRNOP00000069395.2
  ENSRNOP00000072246.2
  ENSRNOP00000092600
  ENSRNOP00000092600.1
Reference Protein Sequences
RefSeq Acc Id: XP_008761940   ⟸   XM_008763718
- UniProtKB: A0A8I6AHZ1 (UniProtKB/TrEMBL),   A0A8L2R0U3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072246   ⟸   ENSRNOT00000088211
RefSeq Acc Id: ENSRNOP00000092600   ⟸   ENSRNOT00000100761
RefSeq Acc Id: ENSRNOP00000069395   ⟸   ENSRNOT00000078547
Protein Domains
Acyl-CoA thioester hydrolase/bile acid-CoA amino   BAAT/Acyl-CoA thioester hydrolase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2H6-F1-model_v2 AlphaFold A0A0G2K2H6 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693734
Promoter ID:EPDNEW_R4252
Type:multiple initiation site
Name:Acnat1_1
Description:acyl-coenzyme A amino acid N-acyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0564,718,048 - 64,718,108EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584701 AgrOrtholog
BioCyc Gene G2FUF-41330 BioCyc
Ensembl Genes ENSRNOG00000051912 UniProtKB/TrEMBL
  ENSRNOG00000056688 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000065119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078547.2 UniProtKB/TrEMBL
  ENSRNOT00000088211.2 UniProtKB/TrEMBL
  ENSRNOT00000089232.2 UniProtKB/TrEMBL
  ENSRNOT00000100761.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2240 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Acyl-CoA_thioEstase_long-chain UniProtKB/TrEMBL
  BAAT_C UniProtKB/TrEMBL
  Thio_Ohase/aa_AcTrfase UniProtKB/TrEMBL
  Thio_Ohase/BAAT_N UniProtKB/TrEMBL
KEGG Report rno:681043 UniProtKB/TrEMBL
NCBI Gene 681043 ENTREZGENE
PANTHER ACYL-COENZYME A AMINO ACID N-ACYLTRANSFERASE 1-RELATED UniProtKB/TrEMBL
  ACYL-COENZYME A THIOESTERASE-RELATED UniProtKB/TrEMBL
Pfam BAAT_C UniProtKB/TrEMBL
  Bile_Hydr_Trans UniProtKB/TrEMBL
PhenoGen Acnat1 PhenoGen
PIRSF Acyl-CoA_hydro UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051912 RatGTEx
  ENSRNOG00000056688 RatGTEx
  ENSRNOG00000065119 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A0G2JV92_RAT UniProtKB/TrEMBL
  A0A0G2K2H6_RAT UniProtKB/TrEMBL
  A0A8I6AHZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R0U3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Acnat1  acyl-coenzyme A amino acid N-acyltransferase 1  LOC679175  similar to bile acid Coenzyme A: amino acid N-acyltransferase  Data merged from RGD:1591823 1643240 APPROVED
2008-11-11 Acnat1  acyl-coenzyme A amino acid N-acyltransferase 1  LOC681043  similar to bile acid Coenzyme A: amino acid N-acyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679175  similar to bile acid Coenzyme A: amino acid N-acyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC681043  similar to bile acid Coenzyme A: amino acid N-acyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL