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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:Kit signaling pathway
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Accession:GO:0038109 term browser browse the term
Definition:The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
Synonyms:exact_synonym: Kit signalling pathway;   SCF signaling pathway;   stem cell factor receptor signaling pathway;   stem cell factor signaling pathway


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Kit signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fer FER tyrosine kinase involved_in ISS
ISO		 GO_REF:0000024
(MGI:2385502|PMID:12192036)		 UniProt
RGD		 PMID:12192036 GO_REF:0000024 MGI:2385502 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in ISO
IBA		 (PMID:17662946)
GO_REF:0000033		 RGD
GO_Central		 PMID:17662946 GO_REF:0000033 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of ISO MGI:3051384 (PMID:16533754) RGD PMID:16533754 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
negative regulation of Kit signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (PMID:16533754) RGD PMID:16533754 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in ISO GO:1990782 (MGI:3041996|PMID:14612394) RGD PMID:14612394 MGI:3041996 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      signal transduction 7209
        cell surface receptor signaling pathway 2886
          cytokine-mediated signaling pathway 492
            Kit signaling pathway 4
              negative regulation of Kit signaling pathway 2
              positive regulation of Kit signaling pathway 0
              regulation of Kit signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of cellular process 12748
          signal transduction 7209
            cell surface receptor signaling pathway 2886
              enzyme-linked receptor protein signaling pathway 1053
                cell surface receptor protein tyrosine kinase signaling pathway 664
                  Kit signaling pathway 4
                    negative regulation of Kit signaling pathway 2
                    positive regulation of Kit signaling pathway 0
                    regulation of Kit signaling pathway + 2
paths to the root