Gene: Sh2b3 (SH2B adaptor protein 3)
Rattus norvegicus
Symbol:
Sh2b3
Name:
SH2B adaptor protein 3
Description:
ENCODES a protein that exhibits phosphate ion binding; protein complex binding; INVOLVED IN cell differentiation (ortholog); embryonic hemopoiesis (ortholog); hemopoiesis (ortholog); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; ASSOCIATED WITH Polycythemia, primary familial and congenital (ortholog); Primary Myelofibrosis (ortholog); Thrombocythemia, Essential (ortholog); INTERACTS WITH 3H-1,2-dithiole-3-thione; dibutyl phthalate; 17beta-estradiol (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
linker of T-cell receptor pathways; linker of t-cell receptor pathways; Lnk; lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein 3; signal transduction protein Lnk
Orthologs:
Homo sapiens : SH2B3
(SH2B adaptor protein 3)
HGNC
Sh2b3
(SH2B adaptor protein 3)
MGI
Allele / Splice:
Sh2b3em1Mcwi
Sh2b3em2Mcwi
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 12 q16 NCBI RGSC Genome Assembly v5.0 12 42,132,947 - 42,136,714 + NCBI RGSC Genome Assembly v3.4 12 35,954,679 - 35,958,446 + NCBI Rat Celera Assembly 12 36,414,671 - 36,418,438 + NCBI Genome Assembly 3.1 12 35,818,066 - 35,821,834 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17beta-estradiol increases expression ISO RGD:68607 6480464 Estradiol results in increased expression of SH2B3 mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68607 6480464 Tetrachlorodibenzodioxin results in increased expression of SH2B3 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68607 6480464 Tetrachlorodibenzodioxin results in increased expression of SH2B3 mRNA CTD PMID:20106945 PMID:21632981 2-methylcholine affects expression ISO RGD:68607 6480464 beta-methylcholine affects the expression of SH2B3 mRNA CTD PMID:21179406 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of SH2B3 mRNA CTD PMID:19162173 atrazine multiple interactions ISO RGD:68607 6480464 [Atrazine co-treated with Arsenates] results in increased expression of SH2B3 mRNA CTD PMID:18585445 benzo[a]pyrene increases expression ISO RGD:68607 6480464 Benzo(a)pyrene results in increased expression of SH2B3 mRNA CTD PMID:20106945 choline multiple interactions ISO RGD:68608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene CTD PMID:20938992 cisplatin affects response to substance ISO RGD:68607 6480464 SH2B3 protein affects the susceptibility to Cisplatin CTD PMID:16217747 cisplatin increases phosphorylation ISO RGD:68608 6480464 Cisplatin results in increased phosphorylation of SH2B3 protein CTD PMID:22006019 cobalt dichloride decreases expression ISO RGD:68607 6480464 cobaltous chloride results in decreased expression of SH2B3 mRNA CTD PMID:19320972 copper(2+) sulfate increases expression ISO RGD:68607 6480464 Copper Sulfate results in increased expression of SH2B3 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:68607 6480464 Cyclosporine results in increased expression of SH2B3 mRNA CTD PMID:20106945 cyclosporin A increases expression ISO RGD:68607 6480464 Cyclosporine results in increased expression of SH2B3 mRNA CTD PMID:20106945 PMID:21632981 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SH2B3 mRNA CTD PMID:21266533 folic acid multiple interactions ISO RGD:68608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene CTD PMID:20938992 L-methionine multiple interactions ISO RGD:68608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SH2B3 gene CTD PMID:20938992 oxaliplatin decreases expression ISO RGD:68607 6480464 oxaliplatin results in decreased expression of SH2B3 mRNA CTD PMID:17762391 pirinixic acid multiple interactions ISO RGD:68607 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SH2B3 mRNA CTD PMID:19710929 piroxicam increases expression ISO RGD:68607 6480464 Piroxicam results in increased expression of SH2B3 mRNA CTD PMID:21858171 quercetin increases expression ISO RGD:68607 6480464 Quercetin results in increased expression of SH2B3 mRNA CTD PMID:21632981 tert-butyl hydroperoxide increases expression ISO RGD:68607 6480464 tert-Butylhydroperoxide results in increased expression of SH2B3 mRNA CTD PMID:15336504 valproic acid affects expression ISO RGD:68608 6480464 Valproic Acid affects the expression of SH2B3 mRNA CTD PMID:17963808 valproic acid increases expression ISO RGD:68607 6480464 Valproic Acid results in increased expression of SH2B3 mRNA CTD PMID:19101580
Biological Process biological_process ND 1598407 12/2009: no relevant rat data RGD cell differentiation ISO RGD:68608 1624291 MGI:MGI:3041996|PMID:14612394 RGD MGI:MGI:3041996 PMID:14612394 cell differentiation IEA Ensembl:ENSMUSP00000083490 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 embryonic hemopoiesis ISO RGD:68608 1624291 MGI:MGI:3041996|PMID:14612394 RGD MGI:MGI:3041996 PMID:14612394 embryonic hemopoiesis IEA Ensembl:ENSMUSP00000083490 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 hemopoiesis ISO RGD:68608 1624291 MGI:MGI:2180088 RGD MGI:MGI:2178875 PMID:11805142 intracellular signal transduction ISO RGD:68608 1624291 MGI:MGI:2178875|PMID:11805142 RGD MGI:MGI:2178875 PMID:11805142 intracellular signal transduction IEA Ensembl:ENSMUSP00000083490 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component cellular_component ND 1598407 12/2009: no relevant rat data RGD Molecular Function phosphate ion binding IDA 68272 RGD protein binding ISO RGD:68608 1624291 UniProtKB:P05532 RGD MGI:MGI:2178875 PMID:11805142 protein complex binding IDA 68272 RGD
2303575 Insul14 Insulin level QTL 14 4 Insulin level 12 1 43562201 Rat 737979 Pia22 Pristane induced arthritis QTL 22 4.1 Joint/bone inflammation arthritis severity 12 530865 45530865 Rat 61416 Pia4 Pristane induced arthritis QTL 4 8.4 Joint/bone inflammation number of affected paws 12 568621 45568621 Rat 634351 Apr5 Acute phase response QTL 5 6.7 IL-6 level pristane induced 12 568621 45568621 Rat 2302042 Pia38 Pristane induced arthritis QTL 38 3.5 .001 Joint/bone inflammation pristane induced 12 568621 45568621 Rat 634350 Apr4 Acute phase response QTL 4 6 Alpha1 acid glycoprotein level pristane induced 12 2248421 46782294 Rat 61421 Cia12 Collagen induced arthritis QTL 12 4.6 Joint/bone inflammation type II collagen induced 12 7148164 36894750 Rat 1549829 Scl48 Serum cholesterol level QTL 48 5 Lipid level baseline serum cholesterol 12 10716230 46782294 Rat 1331761 Bp218 Blood pressure QTL 218 2.973 Blood pressure mean arterial 12 11416955 46782294 Rat 2293699 Bss49 Bone structure and strength QTL 49 5.61 .0001 Bone structure 12 11612769 46782294 Rat 2300186 Bmd59 Bone mineral density QTL 59 7.1 .0001 Bone mineral density 12 11612769 46782294 Rat 61404 Bw120 Body weight QTL 120 5.1 Body weight body mass index 12 12770194 42387195 Rat 1641928 Alcrsp5 Alcohol response QTL 5 Alcohol response loss of righting reflex 12 13948769 46782294 Rat 2303569 Gluco44 Glucose level QTL 44 2 Glucose level fasting 12 13948769 46782294 Rat 2302060 Pia37 Pristane induced arthritis QTL 37 6.1 .001 Joint/bone inflammation pristane induced 12 14334630 46782294 Rat 1549902 Bp269 Blood pressure QTL 269 Blood pressure diastolic, daytime 12 14356765 46782294 Rat 1549912 Bp268 Blood pressure QTL 268 Blood pressure diastolic, daytime 10 14356765 46782294 Rat 631543 Bp83 Blood pressure QTL 83 5.8 Blood pressure systolic 12 16535858 39626712 Rat 70213 Niddm27 Non-insulin dependent diabetes mellitus QTL 27 3.72 Glucose level fasting 12 18937438 39323046 Rat 631560 Apr1 Acute phase response QTL 1 6.1 Alpha1 acid glycoprotein level pristane induced 12 20418353 46782294 Rat 1298081 Cia25 Collagen induced arthritis QTL 25 4.7 Joint/bone inflammation arthritis severity 12 20932555 36894750 Rat 737822 Alc10 Alcohol consumption QTL 10 2.2 Consumption level alcohol preference 12 20932559 41447890 Rat 5684888 Pia42 Pristane induced arthritis QTL 42 Joint/bone inflammation pristane induced 12 20932559 43863270 Rat 70169 Eae13 Experimental allergic encephalomyelitis QTL 13 .032 Brain/spinal cord inflammation demyelination 12 25367251 37906389 Rat 1556747 Calcic1 Intracellular calcium level QTL 1 3.6 Intracellular calcium level thrombin-stimulated 12 29130180 42387195 Rat 1600386 Calcic2 Intracellular calcium level QTL 2 .001 Intracellular calcium level thrombin-stimulated 12 29130180 42387195 Rat 1300175 Cm5 Cardiac mass QTL 5 3.78 Cardiac mass salt-loaded left ventricle 12 29130180 46043557 Rat 1331787 Rf41 Renal function QTL 41 2.998 Renal function renal blood flow 12 29130304 41447755 Rat 631829 Alc6 Alcohol consumption QTL 6 4.7 Consumption level alcohol preference 12 29675888 39018219 Rat 1300162 Bp188 Blood pressure QTL 188 3.19 Blood pressure salt-loaded systolic 12 33216127 46043557 Rat
Gene-Chemical Interaction Annotations
