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ONTOLOGY REPORT - ANNOTATIONS

Term:diacylglycerol-dependent serine/threonine kinase activity
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Accession:GO:0004697 term browser browse the term
Definition:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
Synonyms:exact_synonym: PKC activity;   diacylglycerol-activated phospholipid-dependent PKC activity;   diacylglycerol-activated phospholipid-dependent protein kinase C activity
 narrow_synonym: protein kinase Cepsilon activity
 related_synonym: ATP:protein phosphotransferase (diacylglycerol-dependent) activity;   PKC;   PKCalpha;   PKCbeta;   PKCdelta;   PKCepsilon;   PKCgamma;   Pkc1p;   STK24;   cPKC;   cPKCalpha;   cPKCbeta;   cPKCgamma;   nPKC;   nPKCdelta;   nPKCepsilon;   nPKCeta;   nPKCtheta
 alt_id: GO:0004701
 xref: EC:2.7.11.13;   Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT";   Reactome:R-HSA-193703 "IKKbeta is activated";   Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta";   Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin";   Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates CERT1-2";   Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR";   Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR";   Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1";   Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation";   Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3";   Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters";   Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C";   Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP";   Reactome:R-HSA-8932284 "PKC phosphorylates NFE2L2";   Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1";   Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1";   Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3";   Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727";   Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)";   Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation";   Reactome:R-HSA-9796053 "PRKCI phosphorylates NFE2L2";   reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta";   reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3";   reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC";   reactome:R-HSA-5218805 "PKC autophosphorylates";   reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)";   reactome:R-HSA-9626817 "PKC phosphorylates NCF1"


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diacylglycerol-dependent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkn1 protein kinase N1 enables ISO (PMID:18066052) RGD PMID:18066052 NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Pkn2 protein kinase N2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:231,793,584...231,898,953
Ensembl chr 2:231,793,584...231,898,953 		JBrowse link
G Pkn3 protein kinase N3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:13,350,082...13,363,572
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Prkca protein kinase C, alpha enables IDA
ISO
IEA		 (MGI:5619444|PMID:23099255), (MGI:5882922|PMID:7828597), (PMID:12618484), (PMID:12970181)
GO_REF:0000002
GO_REF:0000003
(PMID:12391145), (PMID:17392515), (PMID:25313067), (PMID:7520444), (PMID:7539802)		 RGD
InterPro
UniProt		 PMID:7520444 PMID:7539802 PMID:7828597 PMID:12391145 PMID:12618484 More... GO_REF:0000002 GO_REF:0000003 MGI:5619444 MGI:5882922, RGD:1601478, RGD:5131880, RGD:5131655 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta enables IDA
ISO
IEA		 (PMID:12618484), (PMID:15545601), (PMID:27226533)
GO_REF:0000002
GO_REF:0000003
(PMID:12391145), (PMID:25313067), (PMID:25982116)		 RGD
InterPro
UniProt		 PMID:12391145 PMID:12618484 PMID:15545601 PMID:25313067 PMID:25982116 More... GO_REF:0000002 GO_REF:0000003, RGD:631236 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta enables ISO
IEA
EXP
ISS		 (PMID:12391145), (PMID:18285462)
GO_REF:0000003
GO_REF:0000107
PMID:12198130
(MGI:5444805|PMID:22885697)
GO_REF:0000024		 RGD
UniProt
Ensembl		 PMID:12391145 PMID:18285462 PMID:22885697 PMID:12198130 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 MGI:5444805, RGD:729231 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon enables IMP
IEA
ISO		 PMID:22619279
GO_REF:0000002
(PMID:18556656)		 InterPro
RGD		 PMID:18556656 PMID:22619279 GO_REF:0000002, RGD:10047170 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma enables IDA
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:11507002 GO_REF:0000002, RGD:631236 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkch protein kinase C, eta enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Prkci protein kinase C, iota enables ISO (MGI:3843448|PMID:9819385)
(PMID:12700136)		 RGD PMID:9819385 PMID:12700136 MGI:3843448 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcq protein kinase C, theta enables ISO
IEA		 (PMID:16356856)
(PMID:12618484)
GO_REF:0000003
GO_REF:0000002		 RGD
UniProt
InterPro		 PMID:12618484 PMID:16356856 GO_REF:0000002 GO_REF:0000003 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prkcz protein kinase C, zeta enables IDA
ISO		 (PMID:12391145) RGD PMID:12391145 PMID:20570724 RGD:5131661 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkd1 protein kinase D1 enables ISO
IEA		 (PMID:12637538)
GO_REF:0000003		 RGD
UniProt		 PMID:12637538 GO_REF:0000003 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Prkd2 protein kinase D2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Prkd3 protein kinase D3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443 		JBrowse link
G Set Set nuclear proto-oncogene enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase enables ISO (PMID:11544179) RGD PMID:11544179 NCBI chr 1:172,441,892...172,543,667
Ensembl chr 1:172,444,936...172,543,698 		JBrowse link
calcium,diacylglycerol-dependent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkca protein kinase C, alpha enables IDA
IEA
ISO		 GO_REF:0000107
(PMID:25313067), (PMID:33934390)
(MGI:5882922|PMID:7828597), (PMID:10879655), (PMID:7741753)		 Ensembl
RGD		 PMID:7741753 PMID:7828597 PMID:10879655 PMID:25313067 PMID:33934390 More... GO_REF:0000107 MGI:5882922, RGD:731217, RGD:5131882 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcg protein kinase C, gamma IDA RGD PMID:18972403 RGD:5131882 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcd protein kinase C, delta IDA RGD PMID:1915352 RGD:1642551 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon enables IEA
ISO		 GO_REF:0000107
(PMID:10879655)		 Ensembl
RGD		 PMID:10879655 GO_REF:0000107 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkch protein kinase C, eta IDA RGD PMID:1426252 RGD:729427 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20486
    catalytic activity 6038
      catalytic activity, acting on a protein 2445
        protein kinase activity 622
          protein serine/threonine kinase activity 441
            diacylglycerol-dependent serine/threonine kinase activity 17
              calcium,diacylglycerol-dependent serine/threonine kinase activity 2
              diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20486
    catalytic activity 6038
      transferase activity 2398
        transferase activity, transferring phosphorus-containing groups 972
          kinase activity 804
            protein kinase activity 622
              protein serine/threonine kinase activity 441
                diacylglycerol-dependent serine/threonine kinase activity 17
                  calcium,diacylglycerol-dependent serine/threonine kinase activity 2
                  diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3
paths to the root