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ONTOLOGY REPORT - ANNOTATIONS

Term:transmembrane receptor protein serine/threonine kinase activity
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Accession:GO:0004675 term browser browse the term
Definition:Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
Synonyms:related_synonym: receptor protein serine/threonine kinase activity
 xref: EC:2.7.11.30;   MetaCyc:2.7.11.30-RXN;   RHEA:18673;   reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly";   reactome:R-HSA-198732 "STAT3 activation";   reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly"


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transmembrane receptor protein serine/threonine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 enables IEA
IDA
NAS		 (PMID:19506109), (PMID:19736306)
(PMID:8242742)		 InterPro
UniProt
BHF-UCL
RHEA		 PMID:8242742 PMID:19506109 PMID:19736306 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR1B activin A receptor type 1B enables IEA
NAS		 (PMID:9032295) InterPro
UniProt
HGNC-UCL
RHEA		 PMID:9032295 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G ACVR1C activin A receptor type 1C enables IEA InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864 		JBrowse link
G ACVR2A activin A receptor type 2A enables TAS
IEA		 (PMID:1314589) PINC
UniProt
RHEA
InterPro		 PMID:1314589 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 2:147,844,517...147,930,822
Ensembl chr 2:147,844,517...147,930,826 		JBrowse link
G ACVR2B activin A receptor type 2B enables IEA InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G ACVRL1 activin A receptor like type 1 enables NAS
IEA		 (PMID:8242742) UniProt
InterPro
RHEA		 PMID:8242742 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G AMHR2 anti-Mullerian hormone receptor type 2 enables IEA UniProt
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr12:53,423,855...53,431,672
Ensembl chr12:53,423,855...53,431,672 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A enables IEA
TAS		 InterPro
UniProt
RHEA
Reactome		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 Reactome:R-HSA-201476 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,756,596...86,932,825 		JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B enables IEA
NAS		 (PMID:10051328) Ensembl
UniProt
RHEA
InterPro		 PMID:10051328 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 enables IEA InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 enables IEA
IDA		 (PMID:12015308), (PMID:19736306) RHEA
UniProt
BHF-UCL
InterPro		 PMID:12015308 PMID:19736306 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 enables IDA
IEA		 (PMID:12015308) BHF-UCL
UniProt
RHEA
InterPro		 PMID:12015308 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 GO_REF:0000117 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142 		JBrowse link
activin receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B contributes_to
enables		 IDA (PMID:12665502)
(PMID:12065756)		 HGNC-UCL
ARUK-UCL		 PMID:12065756 PMID:12665502 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G ACVR1C activin A receptor type 1C enables ISO PMID:12065756 ARUK-UCL PMID:12065756 RGD:8553317 NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864 		JBrowse link
G ACVR2A activin A receptor type 2A contributes_to
enables		 IDA
IBA
IEA		 (PMID:12665502)
(PMID:25368322)		 HGNC-UCL
GO_Central
Ensembl
UniProt		 PMID:12665502 PMID:25368322 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:147,844,517...147,930,822
Ensembl chr 2:147,844,517...147,930,826 		JBrowse link
G ACVR2B activin A receptor type 2B enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142 		JBrowse link
activin receptor activity, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 enables
contributes_to		 ISO
IEA
IDA		 (PMID:8242742) RGD
Ensembl
UniProt		 PMID:8242742 PMID:8248234 GO_REF:0000107 RGD:724761 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR1B activin A receptor type 1B enables TAS
IBA
IDA		 (PMID:8622651)
(PMID:9892009)		 HGNC-UCL
GO_Central
UniProt		 PMID:8622651 PMID:9892009 GO_REF:0000033 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G ACVR1C activin A receptor type 1C enables IDA
IBA		 (PMID:12063393) UniProt
GO_Central		 PMID:12063393 GO_REF:0000033 NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864 		JBrowse link
G ACVRL1 activin A receptor like type 1 enables IDA (PMID:22718755), (PMID:8242742) MGI PMID:8242742 PMID:22718755 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
activin receptor activity, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR2B activin A receptor type 2B contributes_to
enables		 TAS
IDA		 (PMID:8622651)
(PMID:8395525)		 HGNC-UCL
UniProt		 PMID:8395525 PMID:8622651 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 enables TAS
IDA		 (PMID:19366699) Reactome
UniProt		 PMID:19366699 Reactome:R-HSA-201443 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
BMP receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 enables IDA (PMID:12065756) ARUK-UCL PMID:12065756 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR2A activin A receptor type 2A enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:147,844,517...147,930,822
Ensembl chr 2:147,844,517...147,930,826 		JBrowse link
G ACVRL1 activin A receptor like type 1 enables IMP
IDA
IGI		 (PMID:26176610)
(PMID:12065756)
(PMID:32082362)		 UniProt
ARUK-UCL
BHF-UCL		 PMID:12065756 PMID:26176610 PMID:32082362 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A enables IEA
IDA
ISS		 (PMID:12065756) Ensembl
ARUK-UCL
UniProt		 PMID:12065756 GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,756,596...86,932,825 		JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B enables IEA
IDA		 (PMID:12065756) Ensembl
ARUK-UCL		 PMID:12065756 GO_REF:0000107 NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 enables IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
G HJV hemojuvelin BMP co-receptor contributes_to IDA (PMID:16604073) BHF-UCL PMID:16604073 NCBI chr 1:146,017,470...146,021,735
Ensembl chr 1:146,017,468...146,036,746 		JBrowse link
G SOSTDC1 sclerostin domain containing 1 enables IDA (PMID:15020244) UniProt PMID:15020244 NCBI chr 7:16,461,481...16,465,738
Ensembl chr 7:16,461,481...16,530,580 		JBrowse link
transforming growth factor beta receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 enables IDA (PMID:8242742) MGI PMID:8242742 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G AMHR2 anti-Mullerian hormone receptor type 2 enables IBA GO_Central GO_REF:0000033 NCBI chr12:53,423,855...53,431,672
Ensembl chr12:53,423,855...53,431,672 		JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751 		JBrowse link
G ENG endoglin enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,815,013...127,854,658 		JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 enables NAS (PMID:8537398) UniProt PMID:8537398 NCBI chr 2:32,946,953...33,399,509
Ensembl chr 2:32,946,953...33,399,509 		JBrowse link
G LTBP4 latent transforming growth factor beta binding protein 4 enables NAS (PMID:9660815) UniProt PMID:9660815 NCBI chr19:40,593,166...40,629,820
Ensembl chr19:40,592,883...40,629,818 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 enables
contributes_to		 IC
IDA
IEA
IMP		 (PMID:1326540)
(PMID:12015308), (PMID:12065756), (PMID:14633705)
(PMID:1333888)
(PMID:18625725)		 BHF-UCL
ARUK-UCL
Ensembl		 PMID:1326540 PMID:1333888 PMID:12015308 PMID:12065756 PMID:14633705 More... GO_REF:0000107 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 enables IMP
IEA
IBA
IDA
IC		 (PMID:1333888)
(PMID:12015308), (PMID:18453574), (PMID:7852346), (PMID:8635485)
(PMID:1326540)		 BHF-UCL
TreeGrafter
GO_Central
Ensembl		 PMID:1326540 PMID:1333888 PMID:7852346 PMID:8635485 PMID:12015308 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 enables IDA
IEA
IBA		 (PMID:12958365) BHF-UCL
TreeGrafter
GO_Central		 PMID:12958365 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335 		JBrowse link
G TGFBR3L transforming growth factor beta receptor 3 like enables IBA GO_Central GO_REF:0000033 NCBI chr19:7,914,830...7,919,097
Ensembl chr19:7,914,830...7,919,097 		JBrowse link
transforming growth factor beta receptor activity, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVRL1 activin A receptor like type 1 enables IDA
IBA		 (PMID:8242742) UniProt
GO_Central		 PMID:8242742 GO_REF:0000033 NCBI chr12:51,906,944...51,923,361
Ensembl chr12:51,906,908...51,923,361 		JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A enables IDA
IBA
IEA		 (PMID:9136927) UniProt
GO_Central
TreeGrafter		 PMID:9136927 GO_REF:0000033 GO_REF:0000118 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,756,596...86,932,825 		JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B enables IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 enables ISO
IBA
IEA
IDA
ISS		 (PMID:8752209) RGD
GO_Central
TreeGrafter
BHF-UCL
AgBase		 PMID:8272871 PMID:8752209 PMID:17505012 PMID:18684975 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 RGD:2302021 RGD:2302517 RGD:737663 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
transforming growth factor beta receptor activity, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMHR2 anti-Mullerian hormone receptor type 2 enables IDA
IEA		 (PMID:10854429) UniProt
Ensembl		 PMID:10854429 GO_REF:0000107 NCBI chr12:53,423,855...53,431,672
Ensembl chr12:53,423,855...53,431,672 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 enables ISO
IEA		 RGD
UniProt
InterPro		 PMID:18684975 GO_REF:0000002 GO_REF:0000104 RGD:2302517 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142 		JBrowse link
transforming growth factor beta receptor activity, type III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR3 transforming growth factor beta receptor 3 enables IDA
IEA		 (PMID:10746731), (PMID:11157754) BHF-UCL
Ensembl		 PMID:10746731 PMID:11157754 GO_REF:0000107 NCBI chr 1:91,680,343...91,906,002
Ensembl chr 1:91,680,343...91,906,335 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19567
    catalytic activity 6005
      catalytic activity, acting on a protein 2452
        protein kinase activity 604
          transmembrane receptor protein kinase activity 87
            transmembrane receptor protein serine/threonine kinase activity 19
              BMP receptor activity 8
              activin receptor activity + 9
              transforming growth factor beta receptor activity + 13
Path 2
Term Annotations click to browse term
  molecular_function 19567
    catalytic activity 6005
      transferase activity 2466
        transferase activity, transferring phosphorus-containing groups 1020
          kinase activity 848
            protein kinase activity 604
              protein serine/threonine kinase activity 447
                transmembrane receptor protein serine/threonine kinase activity 19
                  BMP receptor activity 8
                  activin receptor activity + 9
                  transforming growth factor beta receptor activity + 13
paths to the root